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Literature DB >> 301005

Comparison of in vitro activity of cephalexin, cephradine, and cefaclor.

Abstract

Inhibitory activity of cephalexin, cephradine, and cefaclor was compared by the WHO-ICS agar dilution technique. Cefaclor was substantially more active against staphylococci, streptococci, gonococci, meningococci, Haemophilus, Escherichia coli, Klebsiella pneumoniae, Citrobacter diversus, Proteus mirabilis, salmonellae, and shigellae than was cephalexin, which in turn was more active than cephradine. Cefaclor appeared to be less resistant to staphylococcal penicillinase than did the other two agents. None of these cephalosporins was active against Enterobacter, Serratia, indole-positive Proteeae, Pseudomonas, or Bacteroides fragilis.

Entities: Chemical Species

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Year: 1977 PMID： 301005 PMCID： PMC352009 DOI： 10.1128/AAC.11.3.470

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

9 in total

1. Effect of inoculum and of beta-lactamase on the anti-staphylococcal activity of thirteen penicillins and cephalosporins.

Authors: L D Sabath; C Garner; C Wilcox; M Finland
Journal: Antimicrob Agents Chemother Date: 1975-09 Impact factor: 5.191

2. Antimicrobial susceptibility of Haemophilus influenzae.

Authors: C Thornsberry; L A Kirven
Journal: Antimicrob Agents Chemother Date: 1974-11 Impact factor: 5.191

3. Relative inactivation by Staphylococcus aureus of eight cephalosporin antibiotics.

Authors: I W Fong; E R Engelking; W M Kirby
Journal: Antimicrob Agents Chemother Date: 1976-06 Impact factor: 5.191

4. Clinical evaluation of cephradine, a new oral cephalosporin.

Authors: J F Scholand; G R Hodges; R J Fass; S Saslaw
Journal: Am J Med Sci Date: 1974-02 Impact factor: 2.378

5. Cephradine. Antibacterial activity and clinical effectiveness.

Authors: J Klastersky; D Daneau; D Weerts
Journal: Chemotherapy Date: 1973 Impact factor: 2.544

6. Double-blind comparison of cephradine and cephalexin in the treatment of skin and soft-tissue infections due to Staphylococcus aureus.

Authors: J A Hubsher; H H Gadebusch; A G Itkin
Journal: Curr Ther Res Clin Exp Date: 1976-06

7. Antibiotic susceptibility of gram-negative bacilli isolated from blood cultures. Results of tests with 35 agents and strains from 169 patients at Boston City Hospital during 1972.

Authors: J E McGowan; C Garner; C Wilcox; M Finland
Journal: Am J Med Date: 1974-08 Impact factor: 4.965

8. Spurious ampicillin resistance by testing Haemophilus influenzae with agar containing supplement C.

Authors: J A Washington; R J Snyder; P C Kohner
Journal: Antimicrob Agents Chemother Date: 1976-01 Impact factor: 5.191

9. Hemophilus influenzae type B susceptibility to 17 antibiotics.

Authors: B B Emerson; A L Smith; A L Harding; D H Smith
Journal: J Pediatr Date: 1975-04 Impact factor: 4.406

9 in total

46 in total

9. [In vitro activity of cefaclor against Haemophilus influenzae in comparison to various oral chemotherapeutic agents (author's transl)].

Authors: I Braveny
Journal: Infection Date: 1979 Impact factor: 3.553

10. Cefaclor in the treatment of susceptible infections in infants and children.

Authors: M J Spencer
Journal: Infection Date: 1979 Impact factor: 3.553

Comparison of in vitro activity of cephalexin, cephradine, and cefaclor.

1. Effect of inoculum and of beta-lactamase on the anti-staphylococcal activity of thirteen penicillins and cephalosporins.

2. Antimicrobial susceptibility of Haemophilus influenzae.

3. Relative inactivation by Staphylococcus aureus of eight cephalosporin antibiotics.

4. Clinical evaluation of cephradine, a new oral cephalosporin.

5. Cephradine. Antibacterial activity and clinical effectiveness.

6. Double-blind comparison of cephradine and cephalexin in the treatment of skin and soft-tissue infections due to Staphylococcus aureus.

7. Antibiotic susceptibility of gram-negative bacilli isolated from blood cultures. Results of tests with 35 agents and strains from 169 patients at Boston City Hospital during 1972.

8. Spurious ampicillin resistance by testing Haemophilus influenzae with agar containing supplement C.

9. Hemophilus influenzae type B susceptibility to 17 antibiotics.

1. In vitro investigation of BK-218, a new oral and parenteral cephalosporin.

2. In vitro activity of cefaclor, a new orally administered cephalosporin antibiotic.

3. In vitro susceptibility studies with cefaclor and cephalexin.

Review 4. Haemophilus influenzae: antibiotic susceptibility.

5. In vitro and in vivo antibacterial activities of ME1207, a new oral cephalosporin.

6. Comparative antibacterial activity of a new oral cephalosporin, BMY-28100.

7. In vitro activity of Ro 15-8074, a new oral cephalosporin, against Neisseria gonorrhoeae.

8. [Serum and tissue concentrations after a single dose of cefaclor].

9. [In vitro activity of cefaclor against Haemophilus influenzae in comparison to various oral chemotherapeutic agents (author's transl)].

10. Cefaclor in the treatment of susceptible infections in infants and children.