Literature DB >> 3436316

Comparative in vitro activity of the two new oral cephalosporin metabolites RO 19-5247 and RO 15-8074.

K E Aldridge1, D D Schiro, C V Sanders.   

Abstract

A total of 629 clinical strains of gram positive and gram negative bacteria were tested for their susceptibility to RO 19-5247, RO 15-8074, and other antimicrobial agents. Both RO 19-5247 and RO 15-8074 had good activity against strains of Enterobacteriaceae; however, resistance was found among some strains of Enterobacter, Citrobacter, Klebsiella and Morganella spp. Both compounds showed moderate to poor active against Acinetobacter spp., Pseudomonas aeruginosa, staphylococci and Streptococcus faecalis. Against strains of Haemophilus influenzae, Neisseria gonorrhoeae, Gardnerella vaginalis, Streptococcus pneumoniae and streptococci (not enterococci), each compound was highly active in vitro. RO 19-5247 and RO 15-8074 had comparable activity to cotrimoxazole, ceftazidime and ceftizoxime. Each new compound had considerably better activity then did cefaclor and amoxicillin/potassium clavulanate.

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Year:  1987        PMID： 3436316     DOI： 10.1007/BF02014247

Source DB:  PubMed          Journal:  Eur J Clin Microbiol        ISSN： 0722-2211            Impact factor:   3.267


  7 in total

1.  In vitro activity of RO 15-8074 and RO 19-5247.

Authors:  T Valle; E Jalanko; L Scheinin; O V Renkonen
Journal:  Eur J Clin Microbiol       Date:  1987-04       Impact factor: 3.267

2.  Antimicrobial activity of Ro 15-8074, active metabolite of a new oral cephalosporin (Ro 15-8075), against 7,775 recent clinical isolates.

Authors:  R N Jones; P C Fuchs; A L Barry; L W Ayers; E H Gerlach; T L Gavan
Journal:  Antimicrob Agents Chemother       Date:  1986-12       Impact factor: 5.191

3.  In vitro activity of Ro 15-8074, a new oral cephalosporin, against Neisseria gonorrhoeae.

Authors:  W S Ng; P Y Chau; Y K Leung; P C Wong
Journal:  Antimicrob Agents Chemother       Date:  1985-09       Impact factor: 5.191

4.  In-vitro activity of Ro-15-8074, a new oral cephalosporin.

Authors:  M Peeters; P Piot
Journal:  J Antimicrob Chemother       Date:  1985-10       Impact factor: 5.790

5.  In vitro activity and beta-lactamase stability of two oral cephalosporins, ceftetrame (Ro 19-5247) and cefetamet (Ro 15-8074).

Authors:  H C Neu; N X Chin; P Labthavikul
Journal:  Antimicrob Agents Chemother       Date:  1986-09       Impact factor: 5.191

6.  In vitro activities of Ro 19-5247 and Ro 15-8074, new oral cephalosporins.

Authors:  R J Fass; V L Helsel
Journal:  Antimicrob Agents Chemother       Date:  1986-09       Impact factor: 5.191

7.  In vitro activity of Ro 15-8074 and Ro 19-5247, two orally administered cephalosporin metabolites.

Authors:  R Wise; J M Andrews; L J Piddock
Journal:  Antimicrob Agents Chemother       Date:  1986-06       Impact factor: 5.191
  7 in total
  2 in total

Review 1.  Cefetamet pivoxil. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use.

Authors:  H M Bryson; R N Brogden
Journal:  Drugs       Date:  1993-04       Impact factor: 9.546

Review 2.  Cefetamet pivoxil clinical pharmacokinetics.

Authors:  R A Blouin; K Stoeckel
Journal:  Clin Pharmacokinet       Date:  1993-09       Impact factor: 6.447
  2 in total

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