Literature DB >> 3492961

Antimicrobial activity of Ro 15-8074, active metabolite of a new oral cephalosporin (Ro 15-8075), against 7,775 recent clinical isolates.

R N Jones, P C Fuchs, A L Barry, L W Ayers, E H Gerlach, T L Gavan.   

Abstract

Susceptibility testing of 7,775 recent clinical isolates from four medical centers showed Ro 15-8074 to be 2-to greater than 8-fold more active than either cefaclor or cefuroxime against the Enterobacteriaceae. Ro 15-8074 MICs for 50% of the strains tested were greater than or equal to 32 micrograms/ml for Staphylococcus spp., enterococci, Pseudomonas aeruginosa, and Pseudomonas maltophilia. beta-Lactamase hydrolysis experiments failed to demonstrate significant Ro 15-8074 inactivation by commonly encountered chromosomal or plasmid-mediated enzymes (P99, K1, K14, TEM, and CARB).

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Year:  1986        PMID： 3492961      PMCID： PMC180632          DOI： 10.1128/AAC.30.6.961

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  10 in total

1.  Cefuroxime, an in vitro Comparison with Six Other Cephalosporins.

Authors:  A L Barry; C Thornsberry; R N Jones; P C Fuchs; T L Gavan; E H Gerlach
Journal:  Proc R Soc Med       Date:  1977

Review 2.  The beta-lactamases of gram-negative bacteria and their possible physiological role.

Authors:  M H Richmond; R B Sykes
Journal:  Adv Microb Physiol       Date:  1973       Impact factor: 3.517

3.  In vitro activity of Ro 15-8074, a new oral cephalosporin, against Neisseria gonorrhoeae.

Authors:  W S Ng; P Y Chau; Y K Leung; P C Wong
Journal:  Antimicrob Agents Chemother       Date:  1985-09       Impact factor: 5.191

4.  In-vitro activity of Ro-15-8074, a new oral cephalosporin.

Authors:  M Peeters; P Piot
Journal:  J Antimicrob Chemother       Date:  1985-10       Impact factor: 5.790

5.  Pharmacology of Cefuroxime as the 1-acetoxyethyl ester in volunteers.

Authors:  S M Harding; P E Williams; J Ayrton
Journal:  Antimicrob Agents Chemother       Date:  1984-01       Impact factor: 5.191

6.  Comparison of the antibacterial spectra of cephalexin and cefaclor with those of cephalothin and newer cephalosporins: reevaluation of the class representative concept of susceptibility testing.

Authors:  D A Preston; R N Jones; A L Barry; C Thornsberry
Journal:  J Clin Microbiol       Date:  1983-06       Impact factor: 5.948

Review 7.  Cefoperazone: a review of its antimicrobial spectrum, beta-lactamase stability, enzyme inhibition, and other in vitro characteristics.

Authors:  R N Jones; A L Barry
Journal:  Rev Infect Dis       Date:  1983 Mar-Apr

8.  Cefadroxil, a new broad-spectrum cephalosporin.

Authors:  R E Buck; K E Price
Journal:  Antimicrob Agents Chemother       Date:  1977-02       Impact factor: 5.191

9.  In vitro activity of Ro 15-8074 and Ro 19-5247, two orally administered cephalosporin metabolites.

Authors:  R Wise; J M Andrews; L J Piddock
Journal:  Antimicrob Agents Chemother       Date:  1986-06       Impact factor: 5.191

10.  LY164846 in vitro antimicrobial activity testing, including disk diffusion susceptibility tests using 30-microgram disks.

Authors:  R N Jones; C Baker; A L Barry; P C Fuchs
Journal:  Antimicrob Agents Chemother       Date:  1986-03       Impact factor: 5.191
  10 in total
  6 in total

1.  Comparative in vitro activity of the two new oral cephalosporin metabolites RO 19-5247 and RO 15-8074.

Authors:  K E Aldridge; D D Schiro; C V Sanders
Journal:  Eur J Clin Microbiol       Date:  1987-10       Impact factor: 3.267

2.  Preliminary antimicrobial susceptibility interpretive criteria for cefetamet (Ro 15-8074) and cefteram (Ro 19-5247) disk tests.

Authors:  R N Jones; A L Barry
Journal:  J Clin Microbiol       Date:  1987-09       Impact factor: 5.948

3.  In vitro antibacterial properties of cefetamet and in vivo activity of its orally absorbable ester derivative, cefetamet pivoxil.

Authors:  P Angehrn; P Hohl; R L Then
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1989-06       Impact factor: 3.267

Review 4.  Cefetamet pivoxil. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use.

Authors:  H M Bryson; R N Brogden
Journal:  Drugs       Date:  1993-04       Impact factor: 9.546

5.  Comparative in vitro activity of cefetamet (RO 15-8074).

Authors:  K Machka; I Braveny
Journal:  Eur J Clin Microbiol       Date:  1987-08       Impact factor: 3.267

6.  Ceftibuten (7432-S, SCH 39720): comparative antimicrobial activity against 4735 clinical isolates, beta-lactamase stability and broth microdilution quality control guidelines.

Authors:  R N Jones; A L Barry
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1988-12       Impact factor: 3.267
  6 in total

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