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Literature DB >> 6983863

Susceptibility of Haemophilus influenzae type b to cefaclor and influence of inoculum size.

Abstract

Cefaclor appeared to be an effective antibiotic against both beta-lactamase-positive and beta-lactamase-negative strains of Haemophilus influenzae type b when tested with 10(5) colony-forming units per ml. With inocula in excess of 10(6) colony-forming units per ml, these organisms were neither inhibited nor killed at concentrations of 400 micrograms/ml. This inoculum effect was also demonstrated in time-kill curve studies.

Entities: Chemical Gene Species

Mesh：

Substances：
Cefaclor
Cephalexin

Year: 1982 PMID： 6983863 PMCID： PMC185688 DOI： 10.1128/AAC.22.5.923

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

10 in total

Review 1. PYELONEPHRITIS IN INFANCY AND CHILDHOOD.

Authors: H D RILEY
Journal: Pediatr Clin North Am Date: 1964-08 Impact factor: 3.278

2. Urinary tract infection in paralytic poliomyelitis.

Authors: H D RILEY; V KNIGHT
Journal: Medicine (Baltimore) Date: 1958-12 Impact factor: 1.889

3. [Possibilities and limits of antibiotic therapy in treatment of respiratory tract diseases].

Authors:
Journal: Monatsschr Kinderheilkd Date: 1956-03

4. In vitro antimicrobial activity comparison of cefaclor (compound 99638), cephradine, and cephalothin.

Authors: R N Jones; E H Gerlach; P C Fuchs
Journal: J Antibiot (Tokyo) Date: 1977-09 Impact factor: 2.649

5. Comparison of in vitro activity of cephalexin, cephradine, and cefaclor.

Authors: N J Bill; J A Washington
Journal: Antimicrob Agents Chemother Date: 1977-03 Impact factor: 5.191

6. Otitis media. Clinical observations, microbiology, and evaluation of therapy.

Authors: C Halsted; M L Lepow; N Balassanian; J Emmerich; E Wolinsky
Journal: Am J Dis Child Date: 1968-05

7. In vitro susceptibility of Haemophilus influenzae to sulfamethoxazole-trimethoprim and cefaclor, cephalexin, and cephradine.

Authors: R Sinai; S Hammerberg; M I Marks; C H Pai
Journal: Antimicrob Agents Chemother Date: 1978-05 Impact factor: 5.191

8. Treatment of acute otitis media of infancy with cefaclor.

Authors: J D Nelson; C M Ginsburg; J C Clahsen; L H Jackson
Journal: Am J Dis Child Date: 1978-10

9. The role of cefamandole in the treatment of Haemophilus influenzae infections in infants and children.

Authors: P H Azimi; P A Chase
Journal: J Pediatr Date: 1981-06 Impact factor: 4.406

10. Cefaclor: in vitro spectrum of activity and beta-lactamase stability.

Authors: H C Neu; K P Fu
Journal: Antimicrob Agents Chemother Date: 1978-04 Impact factor: 5.191

10 in total

7 in total

Susceptibility of Haemophilus influenzae type b to cefaclor and influence of inoculum size.

Review 1. PYELONEPHRITIS IN INFANCY AND CHILDHOOD.

2. Urinary tract infection in paralytic poliomyelitis.

3. [Possibilities and limits of antibiotic therapy in treatment of respiratory tract diseases].

4. In vitro antimicrobial activity comparison of cefaclor (compound 99638), cephradine, and cephalothin.

5. Comparison of in vitro activity of cephalexin, cephradine, and cefaclor.

6. Otitis media. Clinical observations, microbiology, and evaluation of therapy.

7. In vitro susceptibility of Haemophilus influenzae to sulfamethoxazole-trimethoprim and cefaclor, cephalexin, and cephradine.

8. Treatment of acute otitis media of infancy with cefaclor.

9. The role of cefamandole in the treatment of Haemophilus influenzae infections in infants and children.

10. Cefaclor: in vitro spectrum of activity and beta-lactamase stability.

1. Inoculum effect of β-lactam antibiotics.

2. In vitro activity of Ro 15-8074 and Ro 19-5247 in comparison to cefaclor and cefalexin.

3. In vitro activity of Ro 15-8074, a new oral cephalosporin, against Neisseria gonorrhoeae.

4. Surveillance study of resistance in Haemophilus species in Greece.

5. Effect of inoculum size on Haemophilus influenzae type b susceptibility to new and conventional antibiotics.

6. Bactericidal activities of chloramphenicol and eleven other antibiotics against Salmonella spp.

Review 7. Antibiotic resistance in Haemophilus influenzae: mechanisms, clinical importance and consequences for therapy.