Literature DB >> 3766541

Globin genes in Polynesians have many rearrangements including a recently described gamma gamma gamma gamma/.

R J Trent, K N Mickleson, T Wilkinson, J Yakas, M W Dixon, P J Hill, H Kronenberg.   

Abstract

Rearrangements involving genes of the alpha- and beta-globin loci were frequently detected in DNA from Polynesians. A founder effect and genetic drift occurring 2,000-3,000 years ago as Polynesians migrated eastward across the Pacific is proposed as the likely mechanism for these genetic changes that include deletions or additions of alpha-, gamma-, and zeta-globin genes and an unusual restriction fragment length polymorphism (RFLP) associated with the zeta gene. Preliminary data show different frequencies for gene rearrangements between island groups. Further study of these differences should provide additional information on the prehistory of Polynesians.

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Year:  1986        PMID： 3766541      PMCID： PMC1683950     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  18 in total

1.  Influence of alpha thalassaemia on haematological parameters in Polynesian patients.

Authors:  K N Mickleson; M W Dixon; P J Hill; R Bluck; M Eales; J Rutherford; J Yakas; R J Trent
Journal:  N Z Med J       Date:  1985-12-11

2.  Reliable routine estimation of small amounts of foetal haemoglobin by alkali denaturation.

Authors:  M E Pembrey; P McWade; D J Weatherall
Journal:  J Clin Pathol       Date:  1972-08       Impact factor: 3.411

3.  A novel rearrangement of the human beta-like globin gene cluster.

Authors:  R J Trent; D K Bowden; J M Old; J S Wainscoat; J B Clegg; D J Weatherall
Journal:  Nucleic Acids Res       Date:  1981-12-21       Impact factor: 16.971

4.  Two types of triplicated alpha-globin loci in humans.

Authors:  L E Lie-Injo; A R Herrera; Y W Kan
Journal:  Nucleic Acids Res       Date:  1981-08-11       Impact factor: 16.971

Review 5.  Alpha-thalassemia.

Authors:  D R Higgs; D J Weatherall
Journal:  Curr Top Hematol       Date:  1983

6.  Multiple arrangements of the human embryonic zeta globin genes.

Authors:  P Winichagoon; D R Higgs; S E Goodbourn; J Lamb; J B Clegg; D J Weatherall
Journal:  Nucleic Acids Res       Date:  1982-10-11       Impact factor: 16.971

7.  Linkage of beta-thalassaemia mutations and beta-globin gene polymorphisms with DNA polymorphisms in human beta-globin gene cluster.

Authors:  S H Orkin; H H Kazazian; S E Antonarakis; S C Goff; C D Boehm; J P Sexton; P G Waber; P J Giardina
Journal:  Nature       Date:  1982-04-15       Impact factor: 49.962

8.  Association of two DNA polymorphisms in the alpha-globin gene cluster: implications for genetic analysis.

Authors:  J S Wainscoat; D R Higgs; E Kanavakis; A Cao; D Georgiou; J B Clegg; D J Weatherall
Journal:  Am J Hum Genet       Date:  1983-11       Impact factor: 11.025

9.  A new triplicated alpha-globin gene arrangement in man.

Authors:  R J Trent; D R Higgs; J B Clegg; D J Weatherall
Journal:  Br J Haematol       Date:  1981-09       Impact factor: 6.998

10.  Two different molecular organizations account for the single alpha-globin gene of the alpha-thalassemia-2 genotype.

Authors:  S H Embury; J A Miller; A M Dozy; Y W Kan; V Chan; D Todd
Journal:  J Clin Invest       Date:  1980-12       Impact factor: 14.808
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  13 in total

1.  Globin genes in Micronesia: origins and affinities of Pacific Island peoples.

Authors:  D F O'Shaughnessy; A V Hill; D K Bowden; D J Weatherall; J B Clegg
Journal:  Am J Hum Genet       Date:  1990-01       Impact factor: 11.025

2.  An Asian-specific 9-bp deletion of mitochondrial DNA is frequently found in Polynesians.

Authors:  M Hertzberg; K N Mickleson; S W Serjeantson; J F Prior; R J Trent
Journal:  Am J Hum Genet       Date:  1989-04       Impact factor: 11.025

3.  Non-deletion haemoglobin H disease in Papua New Guinea.

Authors:  A V Hill; S L Thein; B Mavo; D J Weatherall; J B Clegg
Journal:  J Med Genet       Date:  1987-12       Impact factor: 6.318

4.  Globin genes are useful markers to identify genetic similarities between Fijians and Pacific Islanders from Polynesia and Melanesia.

Authors:  R J Trent; J G Buchanan; A Webb; R P Goundar; L M Seruvatu; K N Mickleson
Journal:  Am J Hum Genet       Date:  1988-04       Impact factor: 11.025

5.  Polynesian origins and affinities: globin gene variants in eastern Polynesia.

Authors:  A V Hill; B Gentile; J M Bonnardot; J Roux; D J Weatherall; J B Clegg
Journal:  Am J Hum Genet       Date:  1987-05       Impact factor: 11.025

6.  Alpha-globin gene haplotypes in Polynesians: their relationships to population groups and gene rearrangements.

Authors:  M S Hertzberg; K N Mickleson; R J Trent
Journal:  Am J Hum Genet       Date:  1988-12       Impact factor: 11.025

7.  Polynesian genetic affinities with Southeast Asian populations as identified by mtDNA analysis.

Authors:  T Melton; R Peterson; A J Redd; N Saha; A S Sofro; J Martinson; M Stoneking
Journal:  Am J Hum Genet       Date:  1995-08       Impact factor: 11.025

8.  Homology requirements for unequal crossing over in humans.

Authors:  A B Metzenberg; G Wurzer; T H Huisman; O Smithies
Journal:  Genetics       Date:  1991-05       Impact factor: 4.562

Review 9.  Why are some genetic diseases common? Distinguishing selection from other processes by molecular analysis of globin gene variants.

Authors:  J Flint; R M Harding; J B Clegg; A J Boyce
Journal:  Hum Genet       Date:  1993-03       Impact factor: 4.132

10.  Prevalence and molecular heterogeneity of alfa+ thalassemia in two tribal populations from Andhra Pradesh, India.

Authors:  R Fodde; M Losekoot; M H van den Broek; M Oldenburg; N Rashida; A Schreuder; J T Wijnen; P C Giordano; N V Nayudu; P M Khan
Journal:  Hum Genet       Date:  1988-10       Impact factor: 4.132
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