Literature DB >> 6316779

Association of two DNA polymorphisms in the alpha-globin gene cluster: implications for genetic analysis.

J S Wainscoat, D R Higgs, E Kanavakis, A Cao, D Georgiou, J B Clegg, D J Weatherall.   

Abstract

A new polymorphic BgI II restriction endonuclease site in the alpha-globin gene complex has been found in Cypriot, Sardinian, and Greek populations. In all cases, this polymorphism is linked to a particular hypervariable region between the zeta 2 and zeta 1 genes. This suggests that these hypervariable regions are stable and will be useful for genetic analysis.

Mesh：

Substances：

Year:  1983        PMID： 6316779      PMCID： PMC1685971     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  9 in total

1.  Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors:  E M Southern
Journal:  J Mol Biol       Date:  1975-11-05       Impact factor: 5.469

2.  Highly variable regions of DNA flank the human alpha globin genes.

Authors:  D R Higgs; S E Goodbourn; J S Wainscoat; J B Clegg; D J Weatherall
Journal:  Nucleic Acids Res       Date:  1981-09-11       Impact factor: 16.971

3.  Nonrandom association of polymorphic restriction sites in the beta-globin gene cluster.

Authors:  S E Antonarakis; C D Boehm; P J Giardina; H H Kazazian
Journal:  Proc Natl Acad Sci U S A       Date:  1982-01       Impact factor: 11.205

4.  Mapping the alpha-globin genes in Hb J Mexico carriers.

Authors:  G Trabuchet; F Morle; G Verdier; J Godet; M Benabadji; V M Nigon
Journal:  Hum Genet       Date:  1982       Impact factor: 4.132

5.  The highly polymorphic region near the human insulin gene is composed of simple tandemly repeating sequences.

Authors:  G I Bell; M J Selby; W J Rutter
Journal:  Nature       Date:  1982-01-07       Impact factor: 49.962

6.  Insertion of synthetic copies of human globin genes into bacterial plasmids.

Authors:  J T Wilson; L B Wilson; J K deRiel; L Villa-komaroff; A Efstratiadis; B G Forget; S M Weissman
Journal:  Nucleic Acids Res       Date:  1978-02       Impact factor: 16.971

7.  The chromosomal arrangement of human alpha-like globin genes: sequence homology and alpha-globin gene deletions.

Authors:  J Lauer; C K Shen; T Maniatis
Journal:  Cell       Date:  1980-05       Impact factor: 41.582

8.  Gene deletions in alpha thalassemia prove that the 5' zeta locus is functional.

Authors:  L Pressley; D R Higgs; J B Clegg; D J Weatherall
Journal:  Proc Natl Acad Sci U S A       Date:  1980-06       Impact factor: 11.205

9.  A common mutant EcoRI restriction endonuclease site in the 5' flanking portion of the human alpha-globin gene.

Authors:  E Beutler; W Kuhl; C Johnson
Journal:  Proc Natl Acad Sci U S A       Date:  1981-11       Impact factor: 11.205
  9 in total
  11 in total

1.  Frequency and molecular types of deletional alpha-thalassemia in Egypt.

Authors:  A Novelletto; M Hafez; A Di Rienzo; L Felicetti; G Deidda; Z el Morsi; Y al-Tonbary; M el-Ziny; N Abd-el-Gelil; L Terrenato
Journal:  Hum Genet       Date:  1989-02       Impact factor: 4.132

2.  Alpha-thalassemia haplotypes in the Algerian population.

Authors:  T Henni; F Morlé; B Lopez; P Colonna; J Godet
Journal:  Hum Genet       Date:  1987-03       Impact factor: 4.132

3.  Detection of a restriction site polymorphism within the human alpha-globin gene complex.

Authors:  G Assum; E U Griese; J Horst
Journal:  Hum Genet       Date:  1985       Impact factor: 4.132

4.  Analysis of the human alpha-globin gene cluster reveals a highly informative genetic locus.

Authors:  D R Higgs; J S Wainscoat; J Flint; A V Hill; S L Thein; R D Nicholls; H Teal; H Ayyub; T E Peto; A G Falusi
Journal:  Proc Natl Acad Sci U S A       Date:  1986-07       Impact factor: 11.205

5.  An elongated segment of DNA observed between two human alpha globin genes.

Authors:  T Nakatsuji; H Landman; T H Huisman
Journal:  Hum Genet       Date:  1986-12       Impact factor: 4.132

6.  The dynamics of interlocus associations in the three locus hitchhiking model. 1. The three-way linkage disequilibrium function.

Authors:  M A Asmussen
Journal:  J Math Biol       Date:  1986       Impact factor: 2.259

7.  The dynamics of interlocus associations in the three-locus hitchhiking model. 2. The pairwise linkage disequilibrium between two neutral loci.

Authors:  M A Asmussen
Journal:  J Math Biol       Date:  1986       Impact factor: 2.259

8.  Globin genes in Polynesians have many rearrangements including a recently described gamma gamma gamma gamma/.

Authors:  R J Trent; K N Mickleson; T Wilkinson; J Yakas; M W Dixon; P J Hill; H Kronenberg
Journal:  Am J Hum Genet       Date:  1986-09       Impact factor: 11.025

9.  A large deletion encompassing the entire alpha-like globin gene cluster in a family of northern European extraction.

Authors:  P Fortina; K Delgrosso; E Rappaport; M Poncz; S K Ballas; E Schwartz; S Surrey
Journal:  Nucleic Acids Res       Date:  1988-12-09       Impact factor: 16.971

Review 10.  DNA polymorphism and molecular pathology of the human globin gene clusters.

Authors:  S E Antonarakis; H H Kazazian; S H Orkin
Journal:  Hum Genet       Date:  1985       Impact factor: 4.132
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.