Literature DB >> 2892939

Non-deletion haemoglobin H disease in Papua New Guinea.

A V Hill1, S L Thein, B Mavo, D J Weatherall, J B Clegg.   

Abstract

Analysis of DNA from members of a Melanesian family from Papua New Guinea with haemoglobin (Hb) H disease revealed that all four alpha globin genes are intact in affected subjects. Study of restriction enzyme site and length polymorphisms and the use of oligonucleotide probes indicated that the molecular basis of this Papuan form of non-deletion Hb H disease differs from the previously described Middle Eastern and Mediterranean types.

Entities:  

Mesh：

Year:  1987        PMID： 2892939      PMCID： PMC1050406          DOI： 10.1136/jmg.24.12.767

Source DB:  PubMed          Journal:  J Med Genet        ISSN： 0022-2593            Impact factor:   6.318


  15 in total

1.  Haemoglobin H disease in a Papuan.

Authors:  B P RYAN; A L CAMPBELL; P BRAIN
Journal:  Med J Aust       Date:  1961-12-02       Impact factor: 7.738

2.  Melanesians and Polynesians share a unique alpha-thalassemia mutation.

Authors:  A V Hill; D K Bowden; R J Trent; D R Higgs; S J Oppenheimer; S L Thein; K N Mickleson; D J Weatherall; J B Clegg
Journal:  Am J Hum Genet       Date:  1985-05       Impact factor: 11.025

3.  Analysis of the human alpha-globin gene cluster reveals a highly informative genetic locus.

Authors:  D R Higgs; J S Wainscoat; J Flint; A V Hill; S L Thein; R D Nicholls; H Teal; H Ayyub; T E Peto; A G Falusi
Journal:  Proc Natl Acad Sci U S A       Date:  1986-07       Impact factor: 11.205

4.  High frequencies of alpha-thalassaemia are the result of natural selection by malaria.

Authors:  J Flint; A V Hill; D K Bowden; S J Oppenheimer; P R Sill; S W Serjeantson; J Bana-Koiri; K Bhatia; M P Alpers; A J Boyce
Journal:  Nature       Date:  1986 Jun 19-25       Impact factor: 49.962

5.  Alpha thalassaemia in Papua New Guinea.

Authors:  S J Oppenheimer; D R Higgs; D J Weatherall; J Barker; R A Spark
Journal:  Lancet       Date:  1984-02-25       Impact factor: 79.321

6.  Two different molecular organizations account for the single alpha-globin gene of the alpha-thalassemia-2 genotype.

Authors:  S H Embury; J A Miller; A M Dozy; Y W Kan; V Chan; D Todd
Journal:  J Clin Invest       Date:  1980-12       Impact factor: 14.808

7.  Relative roles of genetic factors, dietary deficiency, and infection in anaemia in Vanuatu, South-West Pacific.

Authors:  D K Bowden; A V Hill; D R Higgs; D J Weatherall; J B Clegg
Journal:  Lancet       Date:  1985-11-09       Impact factor: 79.321

8.  The rare alpha-thalassemia-1 of blacks is a zeta alpha-thalassemia-1 associated with deletion of all alpha- and zeta-globin genes.

Authors:  A E Felice; M P Cleek; K McKie; V McKie; T H Huisman
Journal:  Blood       Date:  1984-05       Impact factor: 22.113

9.  Alpha-thalassaemia caused by a polyadenylation signal mutation.

Authors:  D R Higgs; S E Goodbourn; J Lamb; J B Clegg; D J Weatherall; N J Proudfoot
Journal:  Nature       Date:  1983 Nov 24-30       Impact factor: 49.962

10.  The molecular basis of alpha-thalassaemia in Thailand.

Authors:  P Winichagoon; D R Higgs; S E Goodbourn; J B Clegg; D J Weatherall; P Wasi
Journal:  EMBO J       Date:  1984-08       Impact factor: 11.598
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