Literature DB >> 3421931

Evidence that the pyrromethane cofactor of hydroxymethylbilane synthase (porphobilinogen deaminase) is bound through the sulphur atom of a cysteine residue.

G J Hart1, A D Miller, A R Battersby.   

Abstract

Hydroxymethylbilane synthase (porphobilinogen deaminase) from Escherichia coli uses a novel pyrromethane cofactor to bind the growing pyrrolic chain for hydroxymethylbilane biosynthesis [Hart, Miller, Leeper & Battersby (1987) J. Chem. Soc. Chem. Commun. 1762-1765]. We show that this cofactor is bound to the protein through the sulphur atom of a cysteine residue.

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Year:  1988        PMID： 3421931      PMCID： PMC1149235          DOI： 10.1042/bj2520909

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  9 in total

1.  Evidence for a dipyrromethane cofactor at the catalytic site of E. coli porphobilinogen deaminase.

Authors:  P M Jordan; M J Warren
Journal:  FEBS Lett       Date:  1987-12-10       Impact factor: 4.124

2.  Purification, N-terminal amino acid sequence and properties of hydroxymethylbilane synthase (porphobilinogen deaminase) from Escherichia coli.

Authors:  G J Hart; C Abell; A R Battersby
Journal:  Biochem J       Date:  1986-11-15       Impact factor: 3.857

Review 3.  The biosynthesis of porphyrins, chlorophylls, and vitamin B12.

Authors:  F J Leeper
Journal:  Nat Prod Rep       Date:  1985-02       Impact factor: 13.423

4.  Mechanism of action of porphobilinogen deaminase. The participation of stable enzyme substrate covalent intermediates between porphobilinogen and the porphobilinogen deaminase from Rhodopseudomonas spheroides.

Authors:  P M Jordan; A Berry
Journal:  Biochem J       Date:  1981-04-01       Impact factor: 3.857

5.  Biosynthesis of the pigments of life: formation of the macrocycle.

Authors:  A R Battersby; C J Fookes; G W Matcham; E McDonald
Journal:  Nature       Date:  1980-05-01       Impact factor: 49.962

Review 6.  The biosynthesis of porphyrins, chlorophylls, and vitamin B12.

Authors:  F J Leeper
Journal:  Nat Prod Rep       Date:  1985-12       Impact factor: 13.423

7.  Reassessment of Ellman's reagent.

Authors:  P W Riddles; R L Blakeley; B Zerner
Journal:  Methods Enzymol       Date:  1983       Impact factor: 1.600

8.  Modification of hydroxymethylbilane synthase (porphobilinogen deaminase) by pyridoxal 5'-phosphate. Demonstration of an essential lysine residue.

Authors:  G J Hart; F J Leeper; A R Battersby
Journal:  Biochem J       Date:  1984-08-15       Impact factor: 3.857

9.  Nucleotide sequence of the hemC locus encoding porphobilinogen deaminase of Escherichia coli K12.

Authors:  S D Thomas; P M Jordan
Journal:  Nucleic Acids Res       Date:  1986-08-11       Impact factor: 16.971
  9 in total
  10 in total

1.  Mutagenesis of arginine residues in the catalytic cleft of Escherichia coli porphobilinogen deaminase that affects dipyrromethane cofactor assembly and tetrapyrrole chain initiation and elongation.

Authors:  P M Jordan; S C Woodcock
Journal:  Biochem J       Date:  1991-12-01       Impact factor: 3.857

Review 2.  Porphobilinogen deaminase and uroporphyrinogen III synthase: structure, molecular biology, and mechanism.

Authors:  P M Shoolingin-Jordan
Journal:  J Bioenerg Biomembr       Date:  1995-04       Impact factor: 2.945

3.  Discovery that the assembly of the dipyrromethane cofactor of porphobilinogen deaminase holoenzyme proceeds initially by the reaction of preuroporphyrinogen with the apoenzyme.

Authors:  P M Shoolingin-Jordan; M J Warren; S J Awan
Journal:  Biochem J       Date:  1996-06-01       Impact factor: 3.857

4.  Evidence that the pyrromethane cofactor of hydroxymethylbilane synthase (porphobilinogen deaminase) is bound to the protein through the sulphur atom of cysteine-242.

Authors:  A D Miller; G J Hart; L C Packman; A R Battersby
Journal:  Biochem J       Date:  1988-09-15       Impact factor: 3.857

5.  Investigation of putative active-site lysine residues in hydroxymethylbilane synthase. Preparation and characterization of mutants in which (a) Lys-55, (b) Lys-59 and (c) both Lys-55 and Lys-59 have been replaced by glutamine.

Authors:  A Hädener; P R Alefounder; G J Hart; C Abell; A R Battersby
Journal:  Biochem J       Date:  1990-10-15       Impact factor: 3.857

Review 6.  Prokaryotic Heme Biosynthesis: Multiple Pathways to a Common Essential Product.

Authors:  Harry A Dailey; Tamara A Dailey; Svetlana Gerdes; Dieter Jahn; Martina Jahn; Mark R O'Brian; Martin J Warren
Journal:  Microbiol Mol Biol Rev       Date:  2017-01-25       Impact factor: 11.056

7.  Studies on the mechanism of hydroxymethylbilane synthase concerning the role of arginine residues in substrate binding.

Authors:  M Lander; A R Pitt; P R Alefounder; D Bardy; C Abell; A R Battersby
Journal:  Biochem J       Date:  1991-04-15       Impact factor: 3.857

8.  Evidence that pyridoxal phosphate modification of lysine residues (Lys-55 and Lys-59) causes inactivation of hydroxymethylbilane synthase (porphobilinogen deaminase).

Authors:  A D Miller; L C Packman; G J Hart; P R Alefounder; C Abell; A R Battersby
Journal:  Biochem J       Date:  1989-08-15       Impact factor: 3.857

9.  Purification and properties of porphobilinogen deaminase from Arabidopsis thaliana.

Authors:  R M Jones; P M Jordan
Journal:  Biochem J       Date:  1994-05-01       Impact factor: 3.857

10.  Structure and expression of chloroplast-localized porphobilinogen deaminase from pea (Pisum sativum L.) isolated by redundant polymerase chain reaction.

Authors:  M Witty; A D Wallace-Cook; H Albrecht; A J Spano; H Michel; J Shabanowitz; D F Hunt; M P Timko; A G Smith
Journal:  Plant Physiol       Date:  1993-09       Impact factor: 8.340
  10 in total

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