Literature DB >> 6769048

Biosynthesis of the pigments of life: formation of the macrocycle.

A R Battersby, C J Fookes, G W Matcham, E McDonald.   

Abstract

The organic nuclei of chlorophylls, haems, cytochromes and vitamin B12 are biosynthesised from a single tetrapyrrolic intermediate which has an unexpected, rearranged structure. The mechanism of biosynthesis of this key intermediate has now been characterised in detail. Some of the information thereby obtained is also of use in the investigation of human diseases such as the porphyrias.

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Year:  1980        PMID： 6769048     DOI： 10.1038/285017a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  34 in total

1.  Nucleotide sequence and genetic analysis of a 13.1-kilobase-pair Pseudomonas denitrificans DNA fragment containing five cob genes and identification of structural genes encoding Cob(I)alamin adenosyltransferase, cobyric acid synthase, and bifunctional cobinamide kinase-cobinamide phosphate guanylyltransferase.

Authors:  J Crouzet; S Levy-Schil; B Cameron; L Cauchois; S Rigault; M C Rouyez; F Blanche; L Debussche; D Thibaut
Journal:  J Bacteriol       Date:  1991-10       Impact factor: 3.490

Review 2.  Transition-metal complexes of expanded porphyrins.

Authors:  Jonathan L Sessler; Elisa Tomat
Journal:  Acc Chem Res       Date:  2007-03-31       Impact factor: 22.384

Review 3.  Heme biosynthesis and the porphyrias.

Authors:  John D Phillips
Journal:  Mol Genet Metab       Date:  2019-04-22       Impact factor: 4.797

4.  Evidence that the pyrromethane cofactor of hydroxymethylbilane synthase (porphobilinogen deaminase) is bound through the sulphur atom of a cysteine residue.

Authors:  G J Hart; A D Miller; A R Battersby
Journal:  Biochem J       Date:  1988-06-15       Impact factor: 3.857

5.  Evidence that pyridoxal phosphate modification of lysine residues (Lys-55 and Lys-59) causes inactivation of hydroxymethylbilane synthase (porphobilinogen deaminase).

Authors:  A D Miller; L C Packman; G J Hart; P R Alefounder; C Abell; A R Battersby
Journal:  Biochem J       Date:  1989-08-15       Impact factor: 3.857

6.  Rat hepatic uroporphyrinogen III co-synthase. Purification and evidence for a bound folate coenzyme participating in the biosynthesis of uroporphyrinogen III.

Authors:  M Kohashi; R P Clement; J Tse; W N Piper
Journal:  Biochem J       Date:  1984-06-15       Impact factor: 3.857

7.  Characterization of the porphobilinogen deaminase deficiency in acute intermittent porphyria. Immunologic evidence for heterogeneity of the genetic defect.

Authors:  P M Anderson; R M Reddy; K E Anderson; R J Desnick
Journal:  J Clin Invest       Date:  1981-07       Impact factor: 14.808

8.  Modification of hydroxymethylbilane synthase (porphobilinogen deaminase) by pyridoxal 5'-phosphate. Demonstration of an essential lysine residue.

Authors:  G J Hart; F J Leeper; A R Battersby
Journal:  Biochem J       Date:  1984-08-15       Impact factor: 3.857

9.  Uroporphyrinogen III synthase knock-in mice have the human congenital erythropoietic porphyria phenotype, including the characteristic light-induced cutaneous lesions.

Authors:  David F Bishop; Annika Johansson; Robert Phelps; Amr A Shady; Maria C M Ramirez; Makiko Yasuda; Andres Caro; Robert J Desnick
Journal:  Am J Hum Genet       Date:  2006-02-09       Impact factor: 11.025

10.  Human uroporphyrinogen III synthase: molecular cloning, nucleotide sequence, and expression of a full-length cDNA.

Authors:  S F Tsai; D F Bishop; R J Desnick
Journal:  Proc Natl Acad Sci U S A       Date:  1988-10       Impact factor: 11.205
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