Literature DB >> 3196304

Evidence that the pyrromethane cofactor of hydroxymethylbilane synthase (porphobilinogen deaminase) is bound to the protein through the sulphur atom of cysteine-242.

A D Miller1, G J Hart, L C Packman, A R Battersby.   

Abstract

The pyrromethane cofactor of hydroxymethylbilane synthase (porphobilinogen deaminase) from Escherichia coli is bound to the protein through the sulphur atom of a cysteine residue [Hart, Miller & Battersby (1988) Biochem. J. 252, 909-912; Beifuss, Hart, Miller & Battersby (1988) Tetrahedron Lett. 29, 2591-2594]. We show that the pyrromethane-binding residue is cysteine-242.

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Year:  1988        PMID： 3196304      PMCID： PMC1135172          DOI： 10.1042/bj2540915

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  12 in total

1.  Evidence for a dipyrromethane cofactor at the catalytic site of E. coli porphobilinogen deaminase.

Authors:  P M Jordan; M J Warren
Journal:  FEBS Lett       Date:  1987-12-10       Impact factor: 4.124

2.  Evidence that the pyrromethane cofactor of hydroxymethylbilane synthase (porphobilinogen deaminase) is bound through the sulphur atom of a cysteine residue.

Authors:  G J Hart; A D Miller; A R Battersby
Journal:  Biochem J       Date:  1988-06-15       Impact factor: 3.857

3.  Primary structure of the activation segment of procarboxypeptidase A from porcine pancreas.

Authors:  J Vendrell; F X Avilés; E Genescà; B San Segundo; F Soriano; E Méndez
Journal:  Biochem Biophys Res Commun       Date:  1986-12-15       Impact factor: 3.575

4.  Purification, N-terminal amino acid sequence and properties of hydroxymethylbilane synthase (porphobilinogen deaminase) from Escherichia coli.

Authors:  G J Hart; C Abell; A R Battersby
Journal:  Biochem J       Date:  1986-11-15       Impact factor: 3.857

Review 5.  The biosynthesis of porphyrins, chlorophylls, and vitamin B12.

Authors:  F J Leeper
Journal:  Nat Prod Rep       Date:  1985-02       Impact factor: 13.423

6.  Mechanism of action of porphobilinogen deaminase. The participation of stable enzyme substrate covalent intermediates between porphobilinogen and the porphobilinogen deaminase from Rhodopseudomonas spheroides.

Authors:  P M Jordan; A Berry
Journal:  Biochem J       Date:  1981-04-01       Impact factor: 3.857

7.  Biosynthesis of the pigments of life: formation of the macrocycle.

Authors:  A R Battersby; C J Fookes; G W Matcham; E McDonald
Journal:  Nature       Date:  1980-05-01       Impact factor: 49.962

Review 8.  The biosynthesis of porphyrins, chlorophylls, and vitamin B12.

Authors:  F J Leeper
Journal:  Nat Prod Rep       Date:  1985-12       Impact factor: 13.423

9.  Modification of hydroxymethylbilane synthase (porphobilinogen deaminase) by pyridoxal 5'-phosphate. Demonstration of an essential lysine residue.

Authors:  G J Hart; F J Leeper; A R Battersby
Journal:  Biochem J       Date:  1984-08-15       Impact factor: 3.857

10.  Amino acid sequence of rat mast cell protease I (chymase).

Authors:  H Le Trong; D C Parmelee; K A Walsh; H Neurath; R G Woodbury
Journal:  Biochemistry       Date:  1987-11-03       Impact factor: 3.162
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  9 in total

1.  Molecular heterogeneity of acute intermittent porphyria: identification of four additional mutations resulting in the CRIM-negative subtype of the disease.

Authors:  M H Delfau; C Picat; F De Rooij; G Voortman; J C Deybach; Y Nordmann; B Grandchamp
Journal:  Am J Hum Genet       Date:  1991-08       Impact factor: 11.025

Review 2.  Porphobilinogen deaminase and uroporphyrinogen III synthase: structure, molecular biology, and mechanism.

Authors:  P M Shoolingin-Jordan
Journal:  J Bioenerg Biomembr       Date:  1995-04       Impact factor: 2.945

3.  Discovery that the assembly of the dipyrromethane cofactor of porphobilinogen deaminase holoenzyme proceeds initially by the reaction of preuroporphyrinogen with the apoenzyme.

Authors:  P M Shoolingin-Jordan; M J Warren; S J Awan
Journal:  Biochem J       Date:  1996-06-01       Impact factor: 3.857

4.  Acute intermittent porphyria caused by a C----T mutation that produces a stop codon in the porphobilinogen deaminase gene.

Authors:  G A Scobie; D H Llewellyn; A J Urquhart; S J Smyth; N A Kalsheker; P R Harrison; G H Elder
Journal:  Hum Genet       Date:  1990-10       Impact factor: 4.132

5.  Oxygen-mediated regulation of porphobilinogen formation in Rhodobacter capsulatus.

Authors:  Alan J Biel; Keith Canada; David Huang; Karl Indest; Karen Sullivan
Journal:  J Bacteriol       Date:  2002-03       Impact factor: 3.490

6.  Evidence that pyridoxal phosphate modification of lysine residues (Lys-55 and Lys-59) causes inactivation of hydroxymethylbilane synthase (porphobilinogen deaminase).

Authors:  A D Miller; L C Packman; G J Hart; P R Alefounder; C Abell; A R Battersby
Journal:  Biochem J       Date:  1989-08-15       Impact factor: 3.857

7.  Subcellular location of the tetrapyrrole synthesis enzyme porphobilinogen deaminase in higher plants: an immunological investigation.

Authors:  M Witty; R M Jones; M S Robb; P M Jordan; A G Smith
Journal:  Planta       Date:  1996       Impact factor: 4.116

8.  Purification and properties of porphobilinogen deaminase from Arabidopsis thaliana.

Authors:  R M Jones; P M Jordan
Journal:  Biochem J       Date:  1994-05-01       Impact factor: 3.857

9.  Structure and expression of chloroplast-localized porphobilinogen deaminase from pea (Pisum sativum L.) isolated by redundant polymerase chain reaction.

Authors:  M Witty; A D Wallace-Cook; H Albrecht; A J Spano; H Michel; J Shabanowitz; D F Hunt; M P Timko; A G Smith
Journal:  Plant Physiol       Date:  1993-09       Impact factor: 8.340
  9 in total

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