| Literature DB >> 3164703 |
S J Fowler1, P Gill, D J Werrett, D R Higgs.
Abstract
A probe detecting a hypervariable region (HVR) 3' to the alpha globin locus on chromosome 16 has been used to produce DNA fingerprints. Segregation analysis has revealed multiple, randomly dispersed DNA fragments inherited in a Mendelian fashion with minimal allelism and linkage. The fingerprints are highly polymorphic (probability of chance association between random individuals much less than 10(-14]. The probe is, therefore, a powerful discriminating tool: it is envisaged that this probe will have forensic applications, including paternity cases, and will be informative in linkage analysis.Mesh:
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Year: 1988 PMID: 3164703 DOI: 10.1007/bf00280553
Source DB: PubMed Journal: Hum Genet ISSN: 0340-6717 Impact factor: 4.132