Literature DB >> 3019666

Molecular characterisation of a hypervariable region downstream of the human alpha-globin gene cluster.

A P Jarman, R D Nicholls, D J Weatherall, J B Clegg, D R Higgs.   

Abstract

We have characterised an unusual, highly polymorphic region of DNA located 8-kb downstream of the human alpha-globin gene complex. This hypervariable region (alpha-globin 3' HVR) is composed of an array of 17-bp tandem repeats, the number of which differs considerably (70-450) from one allele to another. The sequence of the 17-bp repeats is highly conserved within and between alleles. Furthermore, this sequence identifies a core oligonucleotide [5'-GNGGGG(N)ACAG-3'] that is common to three previously characterised hypervariable regions. At reduced stringency, a probe to the 3' HVR detects a new family of multiallelic loci that will be of value in the study of human genetics.

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Year:  1986        PMID： 3019666      PMCID： PMC1167051          DOI： 10.1002/j.1460-2075.1986.tb04437.x

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  34 in total

1.  Evolution of repeated DNA sequences by unequal crossover.

Authors:  G P Smith
Journal:  Science       Date:  1976-02-13       Impact factor: 47.728

2.  Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors:  E M Southern
Journal:  J Mol Biol       Date:  1975-11-05       Impact factor: 5.469

3.  Base sequence and evolution of guinea-pig alpha-satellite DNA.

Authors:  E M Southern
Journal:  Nature       Date:  1970-08-22       Impact factor: 49.962

4.  A simple method for DNA restriction site mapping.

Authors:  H O Smith; M L Birnstiel
Journal:  Nucleic Acids Res       Date:  1976-09       Impact factor: 16.971

5.  Unusual structure of the FB family of transposable elements in Drosophila.

Authors:  M A Truett; R S Jones; S S Potter
Journal:  Cell       Date:  1981-06       Impact factor: 41.582

6.  Sequencing end-labeled DNA with base-specific chemical cleavages.

Authors:  A M Maxam; W Gilbert
Journal:  Methods Enzymol       Date:  1980       Impact factor: 1.600

7.  A highly polymorphic locus in human DNA.

Authors:  A R Wyman; R White
Journal:  Proc Natl Acad Sci U S A       Date:  1980-11       Impact factor: 11.205

8.  Mapping genetic elements of Epstein-Barr virus that facilitate extrachromosomal persistence of Epstein-Barr virus-derived plasmids in human cells.

Authors:  S Lupton; A J Levine
Journal:  Mol Cell Biol       Date:  1985-10       Impact factor: 4.272

Review 9.  Construction of a genetic linkage map in man using restriction fragment length polymorphisms.

Authors:  D Botstein; R L White; M Skolnick; R W Davis
Journal:  Am J Hum Genet       Date:  1980-05       Impact factor: 11.025

10.  The chromosomal arrangement of human alpha-like globin genes: sequence homology and alpha-globin gene deletions.

Authors:  J Lauer; C K Shen; T Maniatis
Journal:  Cell       Date:  1980-05       Impact factor: 41.582
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  69 in total

1.  CpG methylation modifies the genetic stability of cloned repeat sequences.

Authors:  Kerrie Nichol; Christopher E Pearson
Journal:  Genome Res       Date:  2002-08       Impact factor: 9.043

2.  Genetic differences at four DNA typing loci in Finnish, Italian, and mixed Caucasian populations.

Authors:  D E Krane; R W Allen; S A Sawyer; D A Petrov; D L Hartl
Journal:  Proc Natl Acad Sci U S A       Date:  1992-11-15       Impact factor: 11.205

3.  The evolution of tandemly repetitive DNA: recombination rules.

Authors:  R M Harding; A J Boyce; J B Clegg
Journal:  Genetics       Date:  1992-11       Impact factor: 4.562

4.  Comparative analysis of the alpha-like globin clusters in mouse, rat, and human chromosomes indicates a mechanism underlying breaks in conserved synteny.

Authors:  Cristina Tufarelli; Ross Hardison; Webb Miller; Jim Hughes; Kevin Clark; Nicki Ventress; Anna Maria Frischauf; Douglas R Higgs
Journal:  Genome Res       Date:  2004-04       Impact factor: 9.043

5.  Inactivation of human alpha-globin gene expression by a de novo deletion located upstream of the alpha-globin gene cluster.

Authors:  S A Liebhaber; E U Griese; I Weiss; F E Cash; H Ayyub; D R Higgs; J Horst
Journal:  Proc Natl Acad Sci U S A       Date:  1990-12       Impact factor: 11.205

Review 6.  Potential genetic functions of tandem repeated DNA sequence blocks in the human genome are based on a highly conserved "chromatin folding code".

Authors:  P Vogt
Journal:  Hum Genet       Date:  1990-03       Impact factor: 4.132

7.  Genetic linkage map of 46 DNA markers on human chromosome 16.

Authors:  T P Keith; P Green; S T Reeders; V A Brown; P Phipps; A Bricker; K Falls; K S Rediker; J A Powers; C Hogan
Journal:  Proc Natl Acad Sci U S A       Date:  1990-08       Impact factor: 11.205

8.  A clinically homogeneous group of families with facioscapulohumeral (Landouzy-Déjérine) muscular dystrophy: linkage analysis of six autosomes.

Authors:  S J Jacobsen; E S Diala; B V Dorsey; M B Rising; R Graveline; K Falls; P Schultz; C Hogan; K Rediker; C D'Amico
Journal:  Am J Hum Genet       Date:  1990-09       Impact factor: 11.025

9.  Diagnosis of adult polycystic kidney disease by genetic markers and ultrasonographic imaging in a voluntary family register.

Authors:  R G Elles; K A Hodgkinson; N P Mallick; D J O'Donoghue; A P Read; S Rimmer; E A Watters; R Harris
Journal:  J Med Genet       Date:  1994-02       Impact factor: 6.318

10.  Characterization of Deletions of the HBA and HBB Loci by Array Comparative Genomic Hybridization.

Authors:  Daniel E Sabath; Michael A Bender; Vijay G Sankaran; Esther Vamos; Alex Kentsis; Hye-Son Yi; Harvey A Greisman
Journal:  J Mol Diagn       Date:  2015-11-21       Impact factor: 5.568
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