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Literature DB >> 3014536

Analysis of the human alpha-globin gene cluster reveals a highly informative genetic locus.

D R Higgs, J S Wainscoat, J Flint, A V Hill, S L Thein, R D Nicholls, H Teal, H Ayyub, T E Peto, A G Falusi.

Abstract

Extensive molecular studies have characterized 15 dimorphic and 2 multiallelic genetic markers within the human alpha-globin gene cluster. Analysis of these markers in 9 populations has shown that the alpha-globin locus is remarkably polymorphic and is therefore an ideal marker on chromosome 16 for the construction of a human genetic linkage map. The combined analysis of 9 polymorphic markers has established alpha-globin haplotypes that provide the means to study the molecular genetics and common mutants of this cluster. The novel association of a conventional restriction fragment length polymorphism haplotype and linked, hypervariable regions of DNA should allow a comparison of the rate of change of such markers.

Entities: Gene Species

Mesh：

Substances：

Year: 1986 PMID： 3014536 PMCID： PMC323911 DOI： 10.1073/pnas.83.14.5165

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

23 in total

1. Melanesians and Polynesians share a unique alpha-thalassemia mutation.

Authors: A V Hill; D K Bowden; R J Trent; D R Higgs; S J Oppenheimer; S L Thein; K N Mickleson; D J Weatherall; J B Clegg
Journal: Am J Hum Genet Date: 1985-05 Impact factor: 11.025

2. Direct cloning of specific genomic DNA sequences in plasmid libraries following fragment enrichment.

Authors: R D Nicholls; A V Hill; J B Clegg; D R Higgs
Journal: Nucleic Acids Res Date: 1985-11-11 Impact factor: 16.971

3. Recombination within the human embryonic xi-globin locus: a common xi-xi chromosome produced by gene conversion of the psi xi gene.

Authors: A V Hill; R D Nicholls; S L Thein; D R Higgs
Journal: Cell Date: 1985-10 Impact factor: 41.582

4. Localization of the human alpha-globin structural gene to chromosome 16 in somatic cell hybrids by molecular hybridization assay.

Authors: A Deisseroth; A Nienhuis; P Turner; R Velez; W F Anderson; F Ruddle; J Lawrence; R Creagan; R Kucherlapati
Journal: Cell Date: 1977-09 Impact factor: 41.582

5. Highly variable regions of DNA flank the human alpha globin genes.

Authors: D R Higgs; S E Goodbourn; J S Wainscoat; J B Clegg; D J Weatherall
Journal: Nucleic Acids Res Date: 1981-09-11 Impact factor: 16.971

6. Multiple arrangements of the human embryonic zeta globin genes.

Authors: P Winichagoon; D R Higgs; S E Goodbourn; J Lamb; J B Clegg; D J Weatherall
Journal: Nucleic Acids Res Date: 1982-10-11 Impact factor: 16.971

7. Two genetic markers closely linked to adult polycystic kidney disease on chromosome 16.

Authors: S T Reeders; M H Breuning; G Corney; S J Jeremiah; P Meera Khan; K E Davies; D A Hopkinson; P L Pearson; D J Weatherall
Journal: Br Med J (Clin Res Ed) Date: 1986-03-29

8. The chromosomal arrangement of human alpha-like globin genes: sequence homology and alpha-globin gene deletions.

Authors: J Lauer; C K Shen; T Maniatis
Journal: Cell Date: 1980-05 Impact factor: 41.582

9. DNA sequence variants in the G gamma-, A gamma-, delta- and beta-globin genes of man.

Authors: A J Jeffreys
Journal: Cell Date: 1979-09 Impact factor: 41.582

10. Allelic variation and linkage properties of a highly polymorphic restriction fragment in humans.

Authors: S E Goodbourn; D R Higgs; J B Clegg; D J Weatherall
Journal: Mol Biol Med Date: 1984-06

65 in total

1. BamHI polymorphism of locus D2S44 in a West German population as revealed by VNTR probe YNH24.

Authors: L Henke; S Cleef; M Zakrzewska; J Henke
Journal: Int J Legal Med Date: 1990-12 Impact factor: 2.686

2. Extensive genetic diversity in the HLA class II region of Africans, with a focally predominant allele, DRB1*1304.

Authors: A V Hill; C E Allsopp; D Kwiatkowski; T E Taylor; S N Yates; N M Anstey; J J Wirima; D R Brewster; A J McMichael; M E Molyneux
Journal: Proc Natl Acad Sci U S A Date: 1992-03-15 Impact factor: 11.205

3. 2003 William Allan Award address. The Thalassemias: the role of molecular genetics in an evolving global health problem.

Authors: David Weatherall
Journal: Am J Hum Genet Date: 2004-03 Impact factor: 11.025

4. An exclusion map for pre-eclampsia: assuming autosomal recessive inheritance.

Authors: C Hayward; J Livingstone; S Holloway; W A Liston; D J Brock
Journal: Am J Hum Genet Date: 1992-04 Impact factor: 11.025

5. A common disinfectant used in condom processing inhibits endonuclease digestion of sperm DNA.

Authors: S Fadda; S Pelotti; G Pappalardo
Journal: Int J Legal Med Date: 1991 Impact factor: 2.686

6. Linkage disequilibrium between two highly polymorphic microsatellites.

Authors: R Sherrington; G Melmer; M Dixon; D Curtis; B Mankoo; G Kalsi; H Gurling
Journal: Am J Hum Genet Date: 1991-11 Impact factor: 11.025

7. Direct haplotype determination by double ARMS: specificity, sensitivity and genetic applications.

Authors: Y M Lo; P Patel; C R Newton; A F Markham; K A Fleming; J S Wainscoat
Journal: Nucleic Acids Res Date: 1991-07-11 Impact factor: 16.971

Review 8. Potential genetic functions of tandem repeated DNA sequence blocks in the human genome are based on a highly conserved "chromatin folding code".

Authors: P Vogt
Journal: Hum Genet Date: 1990-03 Impact factor: 4.132

9. A study of genetic linkage heterogeneity in adult polycystic kidney disease.

Authors: S T Reeders; M H Breuning; M A Ryynanen; A F Wright; K E Davies; A W King; M L Watson; D J Weatherall
Journal: Hum Genet Date: 1987-08 Impact factor: 4.132

10. Loss of heterozygosity and K-ras gene mutations in gastric cancer.

Authors: G N Ranzani; B Renault; N S Pellegata; P Fattorini; E Magni; F Bacci; D Amadori
Journal: Hum Genet Date: 1993-10-01 Impact factor: 4.132