Literature DB >> 6272199

Highly variable regions of DNA flank the human alpha globin genes.

D R Higgs, S E Goodbourn, J S Wainscoat, J B Clegg, D J Weatherall.   

Abstract

A series of restriction fragment length polymorphisms which are due to DNA rearrangements have been identified within two highly variable regions flanking the human alpha globin genes. The existence of such highly polymorphic areas provides a large number of individual genetic markers for the alpha globin gene cluster on chromosome 16. If, as seems likely, such regions occur frequently throughout the human genome they should be of considerable value in the antenatal diagnosis of genetic disease.

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Year:  1981        PMID： 6272199      PMCID： PMC327430          DOI： 10.1093/nar/9.17.4213

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  13 in total

1.  Organization of the alpha-globin genes in the Chinese alpha-thalassemia syndromes.

Authors:  S H Embury; R V Lebo; A M Dozy; Y W Kan
Journal:  J Clin Invest       Date:  1979-06       Impact factor: 14.808

2.  Genetic heterogeneity in inherited disease.

Authors:  H Harris
Journal:  J Clin Pathol Suppl (R Coll Pathol)       Date:  1974

3.  Purification, properties and specificity of the restriction endonuclease from Bacillus stearothermophilus.

Authors:  C M Clarke; B S Hartley
Journal:  Biochem J       Date:  1979-01-01       Impact factor: 3.857

4.  Isolation of high-molecular-weight DNA from mammalian cells.

Authors:  M Gross-Bellard; P Oudet; P Chambon
Journal:  Eur J Biochem       Date:  1973-07-02

5.  Polymorphism of DNA sequence adjacent to human beta-globin structural gene: relationship to sickle mutation.

Authors:  Y W Kan; A M Dozy
Journal:  Proc Natl Acad Sci U S A       Date:  1978-11       Impact factor: 11.205

6.  Transposition of elements of the 412, copia and 297 dispersed repeated gene families in Drosophila.

Authors:  S S Potter; W J Brorein; P Dunsmuir; G M Rubin
Journal:  Cell       Date:  1979-06       Impact factor: 41.582

7.  Evidence for transposition of dispersed repetitive DNA families in yeast.

Authors:  J R Cameron; E Y Loh; R W Davis
Journal:  Cell       Date:  1979-04       Impact factor: 41.582

8.  Polymorphism of DNA sequence in the beta-globin gene region. Application to prenatal diagnosis of beta 0 thalassemia in Sardinia.

Authors:  Y W Kan; K Y Lee; M Furbetta; A Angius; A Cao
Journal:  N Engl J Med       Date:  1980-01-24       Impact factor: 91.245

9.  The chromosomal arrangement of human alpha-like globin genes: sequence homology and alpha-globin gene deletions.

Authors:  J Lauer; C K Shen; T Maniatis
Journal:  Cell       Date:  1980-05       Impact factor: 41.582

10.  Gene deletions in alpha thalassemia prove that the 5' zeta locus is functional.

Authors:  L Pressley; D R Higgs; J B Clegg; D J Weatherall
Journal:  Proc Natl Acad Sci U S A       Date:  1980-06       Impact factor: 11.205
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  57 in total

1.  BamHI polymorphism of locus D2S44 in a West German population as revealed by VNTR probe YNH24.

Authors:  L Henke; S Cleef; M Zakrzewska; J Henke
Journal:  Int J Legal Med       Date:  1990-12       Impact factor: 2.686

Review 2.  Occurrence of the alpha thalassaemia-mental retardation syndrome (non-deletional type) in an Australian male.

Authors:  M P Harvey; A Kearney; A Smith; R J Trent
Journal:  J Med Genet       Date:  1990-09       Impact factor: 6.318

3.  Variation at the 87A heat shock locus in Drosophila melanogaster.

Authors:  A J Brown
Journal:  Proc Natl Acad Sci U S A       Date:  1983-09       Impact factor: 11.205

4.  Inactivation of human alpha-globin gene expression by a de novo deletion located upstream of the alpha-globin gene cluster.

Authors:  S A Liebhaber; E U Griese; I Weiss; F E Cash; H Ayyub; D R Higgs; J Horst
Journal:  Proc Natl Acad Sci U S A       Date:  1990-12       Impact factor: 11.205

5.  Hypervariable regions of DNA for parentage testing and individual identification.

Authors:  T Yokoi; M Nata; T Odaira; K Sagisaka
Journal:  Z Rechtsmed       Date:  1990

6.  Prenatal diagnosis of alpha-thalassemia by polymerase chain reaction and dual restriction enzyme analysis.

Authors:  R V Lebo; R K Saiki; K Swanson; M A Montano; H A Erlich; M S Golbus
Journal:  Hum Genet       Date:  1990-08       Impact factor: 4.132

7.  [Use of DNA polymorphism in forensic paternity evaluation].

Authors:  L Henke; H Paas; K Hoffmann; J Henke
Journal:  Z Rechtsmed       Date:  1990

8.  Polymorphisms in DNA of Coprinus cinereus.

Authors:  M M Wu; J R Cassidy; P J Pukkila
Journal:  Curr Genet       Date:  1983-09       Impact factor: 3.886

9.  A new hemoglobin variant, hemoglobin Nunobiki [alpha 141 (HC3) Arg----Cys]. Notable influence of the carboxy-terminal cysteine upon various physico-chemical characteristics of hemoglobin.

Authors:  S Shimasaki
Journal:  J Clin Invest       Date:  1985-02       Impact factor: 14.808

10.  Human alpha-globin gene expression is silenced by terminal truncation of chromosome 16p beginning immediately 3' of the zeta-globin gene.

Authors:  L Romao; F Cash; I Weiss; S Liebhaber; M Pirastu; R Galanello; A Loi; E Paglietti; P Ioannou; A Cao
Journal:  Hum Genet       Date:  1992-05       Impact factor: 4.132
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