Literature DB >> 30911994

Leucophyllinines A and B, bisindole alkaloids from Leuconotis eugeniifolia.

Yiming Tang1, Alfarius Eko Nugroho1, Yusuke Hirasawa1, Takahiro Tougan2, Toshihiro Horii2, A Hamid A Hadi3, Hiroshi Morita4.   

Abstract

Two new bisindole alkaloids, leucophyllinines A (1) and B (2) consisting of eburnane and quebrachamine-type skeletons were isolated from the bark of Leuconotis eugeniifolia, and their structures were elucidated on the basis of spectroscopic data. Leucophyllinines A and B showed antiplasmodial activities against Plasmodium falciparum 3D7.

Entities:  

Keywords:  Antiplasmodial activity; Apocynaceae; Bisindole alkaloid; Eburnane; Leuconotis eugeniifolia; Quebrachamine

Mesh：

Substances：

Year:  2019        PMID： 30911994     DOI： 10.1007/s11418-019-01297-5

Source DB:  PubMed          Journal:  J Nat Med        ISSN： 1340-3443            Impact factor:   2.343


  21 in total

1.  Antiplasmodial indole alkaloids from Leuconotis griffithii.

Authors:  Alfarius E Nugroho; Yusuke Hirasawa; Wong Chin Piow; Toshio Kaneda; A Hamid A Hadi; Osamu Shirota; Wiwied Ekasari; Aty Widyawaruyanti; Hiroshi Morita
Journal:  J Nat Med       Date:  2011-08-10       Impact factor: 2.343

2.  Cassiarins C-E, antiplasmodial alkaloids from the flowers of Cassia siamea.

Authors:  Shiori Oshimi; Jun Deguchi; Yusuke Hirasawa; Wiwied Ekasari; Aty Widyawaruyanti; Tutik Sri Wahyuni; Noor Cholies Zaini; Osamu Shirota; Hiroshi Morita
Journal:  J Nat Prod       Date:  2009-10       Impact factor: 4.050

3.  New antiplasmodial indole alkaloids from Hunteria zeylanica.

Authors:  Alfarius E Nugroho; Masatomo Sugai; Yusuke Hirasawa; Takahiro Hosoya; Khalijah Awang; A Hamid A Hadi; Wiwied Ekasari; Aty Widyawaruyanti; Hiroshi Morita
Journal:  Bioorg Med Chem Lett       Date:  2011-04-05       Impact factor: 2.823

4.  Bisnicalaterine A, a vobasine-vobasine bisindole alkaloid from Hunteria zeylanica.

Authors:  Alfarius E Nugroho; Yusuke Hirasawa; Nobuo Kawahara; Yukihiro Goda; Khalijah Awang; A Hamid A Hadi; Hiroshi Morita
Journal:  J Nat Prod       Date:  2009-08       Impact factor: 4.050

5.  Reinereins A and B, new onocerane triterpenoids from Reinwardtiodendron cinereum.

Authors:  Alfarius Eko Nugroho; Daisuke Inoue; Chin Piow Wong; Yusuke Hirasawa; Toshio Kaneda; Osamu Shirota; A Hamid A Hadi; Hiroshi Morita
Journal:  J Nat Med       Date:  2018-02-16       Impact factor: 2.343

6.  Bisleuconothines B-D, Modified Eburnane-Aspidosperma Bisindole Alkaloids from Leuconotis griffithii.

Authors:  Alfarius Eko Nugroho; Wenjia Zhang; Yusuke Hirasawa; Yiming Tang; Chin Piow Wong; Toshio Kaneda; A Hamid A Hadi; Hiroshi Morita
Journal:  J Nat Prod       Date:  2018-10-26       Impact factor: 4.050

7.  TRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesis.

Authors:  Sayaka Aizawa; Toru Okamoto; Yukari Sugiyama; Takahisa Kouwaki; Ayano Ito; Tatsuya Suzuki; Chikako Ono; Takasuke Fukuhara; Masahiro Yamamoto; Masayasu Okochi; Nobuhiko Hiraga; Michio Imamura; Kazuaki Chayama; Ryosuke Suzuki; Ikuo Shoji; Kohji Moriishi; Kyoji Moriya; Kazuhiko Koike; Yoshiharu Matsuura
Journal:  Nat Commun       Date:  2016-05-04       Impact factor: 14.919

8.  An automated haematology analyzer XN-30 distinguishes developmental stages of falciparum malaria parasite cultured in vitro.

Authors:  Takahiro Tougan; Yuhgi Suzuki; Sawako Itagaki; Munehisa Izuka; Yuji Toya; Kinya Uchihashi; Toshihiro Horii
Journal:  Malar J       Date:  2018-02-02       Impact factor: 2.979

9.  Application of the automated haematology analyzer XN-30 for discovery and development of anti-malarial drugs.

Authors:  Takahiro Tougan; Yuji Toya; Kinya Uchihashi; Toshihiro Horii
Journal:  Malar J       Date:  2019-01-14       Impact factor: 2.979

10.  Cycloartane triterpenoid (23R, 24E)-23-acetoxymangiferonic acid inhibited proliferation and migration in B16-F10 melanoma via MITF downregulation caused by inhibition of both β-catenin and c-Raf-MEK1-ERK signaling axis.

Authors:  Toshio Kaneda; Misaki Matsumoto; Yayoi Sotozono; Satoshi Fukami; Alfarius Eko Nugroho; Yusuke Hirasawa; Hadi A Hamid A; Hiroshi Morita
Journal:  J Nat Med       Date:  2018-08-06       Impact factor: 2.343
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  4 in total

1.  Two new sarpagine-type indole alkaloids and antimalarial activity of 16-demethoxycarbonylvoacamine from Tabernaemontana macrocarpa Jack.

Authors:  Puteri Amelia; Alfarius Eko Nugroho; Yusuke Hirasawa; Toshio Kaneda; Takahiro Tougan; Toshihiro Horii; Hiroshi Morita
Journal:  J Nat Med       Date:  2019-05-28       Impact factor: 2.343

2.  Chukranoids A-I, isopimarane diterpenoids from Chukrasia velutina.

Authors:  Alfarius Eko Nugroho; Masaki Tange; Sumi Kusakabe; Yusuke Hirasawa; Osamu Shirota; Michiyo Matsuno; Hajime Mizukami; Takahiro Tougan; Toshihiro Horii; Hiroshi Morita
Journal:  J Nat Med       Date:  2022-05-05       Impact factor: 3.192

Review 3.  Computationally-assisted discovery and structure elucidation of natural products.

Authors:  Alfarius Eko Nugroho; Hiroshi Morita
Journal:  J Nat Med       Date:  2019-05-15       Impact factor: 2.343

4.  Two new bisindole alkaloids from Tabernaemontana macrocarpa Jack.

Authors:  Puteri Amelia; Alfarius Eko Nugroho; Yusuke Hirasawa; Toshio Kaneda; Takahiro Tougan; Toshihiro Horii; Hiroshi Morita
Journal:  J Nat Med       Date:  2021-04-06       Impact factor: 2.343
  4 in total

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