Literature DB >> 33822287

Two new bisindole alkaloids from Tabernaemontana macrocarpa Jack.

Puteri Amelia1,2, Alfarius Eko Nugroho1, Yusuke Hirasawa1, Toshio Kaneda1, Takahiro Tougan3, Toshihiro Horii4, Hiroshi Morita5.   

Abstract

Two new bisindole alkaloids, bisnaecarpamines A (1) and B (2), possessing a vobasine-sarpagine type skeleton were isolated from the bark of Tabernaemontana macrocarpa Jack. Their structures were elucidated by extensive spectroscopic methods and chemical correlation. The absolute configurations of compounds 1 and 2 were established using TDDFT-ECD calculation of the selected isomers. Bisnaecarpamine A exhibited potent antimalarial activity against Plasmodium falciparum 3D7 strain with IC50 value of 28.8 µM.

Entities:  

Keywords:  Antimalarial activity; Bisindole alkaloid; Tabernaemontana macrocarpa Jack

Year:  2021        PMID： 33822287     DOI： 10.1007/s11418-021-01510-4

Source DB:  PubMed          Journal:  J Nat Med        ISSN： 1340-3443            Impact factor:   2.343


  12 in total

1.  Antiplasmodial indole alkaloids from Leuconotis griffithii.

Authors:  Alfarius E Nugroho; Yusuke Hirasawa; Wong Chin Piow; Toshio Kaneda; A Hamid A Hadi; Osamu Shirota; Wiwied Ekasari; Aty Widyawaruyanti; Hiroshi Morita
Journal:  J Nat Med       Date:  2011-08-10       Impact factor: 2.343

2.  Bisleuconothine A Induces Autophagosome Formation by Interfering with AKT-mTOR Signaling Pathway.

Authors:  Chin Piow Wong; Ari Seki; Kaori Horiguchi; Tomokazu Shoji; Takashi Arai; Alfarius Eko Nugroho; Yusuke Hirasawa; Fumiaki Sato; Toshio Kaneda; Hiroshi Morita
Journal:  J Nat Prod       Date:  2015-07-15       Impact factor: 4.050

3.  Studies on the total synthesis of bisindole alkaloids in the vinblastine-vincristine series.

Authors:  J P Kutney
Journal:  Lloydia       Date:  1977 Jan-Feb

4.  New vasorelaxant indole alkaloids, taberniacins A and B, from Tabernaemontana divaricata.

Authors:  Yusuke Hirasawa; Xin Dai; Jun Deguchi; Shota Hatano; Tadahiro Sasaki; Ruri Ohtsuka; Alfarius Eko Nugroho; Toshio Kaneda; Hiroshi Morita
Journal:  J Nat Med       Date:  2019-03-07       Impact factor: 2.343

5.  Two new sarpagine-type indole alkaloids and antimalarial activity of 16-demethoxycarbonylvoacamine from Tabernaemontana macrocarpa Jack.

Authors:  Puteri Amelia; Alfarius Eko Nugroho; Yusuke Hirasawa; Toshio Kaneda; Takahiro Tougan; Toshihiro Horii; Hiroshi Morita
Journal:  J Nat Med       Date:  2019-05-28       Impact factor: 2.343

6.  Leucophyllinines A and B, bisindole alkaloids from Leuconotis eugeniifolia.

Authors:  Yiming Tang; Alfarius Eko Nugroho; Yusuke Hirasawa; Takahiro Tougan; Toshihiro Horii; A Hamid A Hadi; Hiroshi Morita
Journal:  J Nat Med       Date:  2019-03-25       Impact factor: 2.343

Review 7.  Circular dichroism calculation for natural products.

Authors:  Alfarius Eko Nugroho; Hiroshi Morita
Journal:  J Nat Med       Date:  2013-04-07       Impact factor: 2.343

8.  Bisleuconothines B-D, Modified Eburnane-Aspidosperma Bisindole Alkaloids from Leuconotis griffithii.

Authors:  Alfarius Eko Nugroho; Wenjia Zhang; Yusuke Hirasawa; Yiming Tang; Chin Piow Wong; Toshio Kaneda; A Hamid A Hadi; Hiroshi Morita
Journal:  J Nat Prod       Date:  2018-10-26       Impact factor: 4.050

9.  Application of preparative high-speed counter-current chromatography for the separation of two alkaloids from the roots of Tabernaemontana catharinensis (Apocynaceae).

Authors:  Milena S Gonçalves; Ivo J Curcino Vieira; Rodrigo R Oliveira; Raimundo Braz-Filho
Journal:  Molecules       Date:  2011-09-02       Impact factor: 4.411

10.  An automated haematology analyzer XN-30 distinguishes developmental stages of falciparum malaria parasite cultured in vitro.

Authors:  Takahiro Tougan; Yuhgi Suzuki; Sawako Itagaki; Munehisa Izuka; Yuji Toya; Kinya Uchihashi; Toshihiro Horii
Journal:  Malar J       Date:  2018-02-02       Impact factor: 2.979
View more
  1 in total

1.  Chukranoids A-I, isopimarane diterpenoids from Chukrasia velutina.

Authors:  Alfarius Eko Nugroho; Masaki Tange; Sumi Kusakabe; Yusuke Hirasawa; Osamu Shirota; Michiyo Matsuno; Hajime Mizukami; Takahiro Tougan; Toshihiro Horii; Hiroshi Morita
Journal:  J Nat Med       Date:  2022-05-05       Impact factor: 3.192
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.