Literature DB >> 31140017

Two new sarpagine-type indole alkaloids and antimalarial activity of 16-demethoxycarbonylvoacamine from Tabernaemontana macrocarpa Jack.

Puteri Amelia1,2, Alfarius Eko Nugroho1, Yusuke Hirasawa1, Toshio Kaneda1, Takahiro Tougan3, Toshihiro Horii3, Hiroshi Morita4.   

Abstract

Two new sarpagine-type indole alkaloids (1 and 2), together with five known alkaloids; 12-methoxy-4-methylvoachalotine (3), 16-demethoxycarbonylvoacamine (4), isositsirikine (5), affinisine (6), affinine (7), were isolated from the bark of Tabernaemontana macrocarpa Jack. The structures of these alkaloids were determined based on spectroscopic data, chemical correlation, and comparison with the literature. 16-Demethoxycarbonylvoacamine (4) showed antiplasmodial activities against Plasmodium falciparum 3D7 and cytotoxic activities against human cell line, HepG2 cells.

Entities:  

Keywords:  Antimalarial activity; Indole alkaloids; Tabernaemontana macrocarpa Jack

Mesh：

Substances：

Year:  2019        PMID： 31140017     DOI： 10.1007/s11418-019-01317-4

Source DB:  PubMed          Journal:  J Nat Med        ISSN： 1340-3443            Impact factor:   2.343


  15 in total

1.  Antiplasmodial indole alkaloids from Leuconotis griffithii.

Authors:  Alfarius E Nugroho; Yusuke Hirasawa; Wong Chin Piow; Toshio Kaneda; A Hamid A Hadi; Osamu Shirota; Wiwied Ekasari; Aty Widyawaruyanti; Hiroshi Morita
Journal:  J Nat Med       Date:  2011-08-10       Impact factor: 2.343

Review 2.  Ethnopharmacology, phytochemistry, and biotechnological advances of family Apocynaceae: A review.

Authors:  Bhushan S Bhadane; Mohini P Patil; Vijay L Maheshwari; Ravindra H Patil
Journal:  Phytother Res       Date:  2018-03-25       Impact factor: 5.878

3.  Bisnicalaterines B and C, atropisomeric bisindole alkaloids from Hunteria zeylanica, showing vasorelaxant activity.

Authors:  Yusuke Hirasawa; Mayumi Hara; Alfarius E Nugroho; Masatomo Sugai; Kazumasa Zaima; Nobuo Kawahara; Yukihiro Goda; Khalijah Awang; A Hamid A Hadi; Marc Litaudon; Hiroshi Morita
Journal:  J Org Chem       Date:  2010-06-18       Impact factor: 4.354

4.  Leucophyllinines A and B, bisindole alkaloids from Leuconotis eugeniifolia.

Authors:  Yiming Tang; Alfarius Eko Nugroho; Yusuke Hirasawa; Takahiro Tougan; Toshihiro Horii; A Hamid A Hadi; Hiroshi Morita
Journal:  J Nat Med       Date:  2019-03-25       Impact factor: 2.343

5.  Vasorelaxant activity of indole alkaloids from Tabernaemontana dichotoma.

Authors:  Kazumasa Zaima; Ikumi Koga; Nobuhide Iwasawa; Takahiro Hosoya; Yusuke Hirasawa; Toshio Kaneda; Intan Safinar Ismail; Nordin Hj Lajis; Hiroshi Morita
Journal:  J Nat Med       Date:  2012-02-21       Impact factor: 2.343

Review 6.  Progress of pharmacological studies on alkaloids from Apocynaceae.

Authors:  Lu Liu; Jian-Xin Cao; Yuan-Cheng Yao; Sheng-Ping Xu
Journal:  J Asian Nat Prod Res       Date:  2012-12-19       Impact factor: 1.569

7.  Synchronization of Plasmodium falciparum erythrocytic stages in culture.

Authors:  C Lambros; J P Vanderberg
Journal:  J Parasitol       Date:  1979-06       Impact factor: 1.276

8.  Bisleuconothines B-D, Modified Eburnane-Aspidosperma Bisindole Alkaloids from Leuconotis griffithii.

Authors:  Alfarius Eko Nugroho; Wenjia Zhang; Yusuke Hirasawa; Yiming Tang; Chin Piow Wong; Toshio Kaneda; A Hamid A Hadi; Hiroshi Morita
Journal:  J Nat Prod       Date:  2018-10-26       Impact factor: 4.050

9.  Application of preparative high-speed counter-current chromatography for the separation of two alkaloids from the roots of Tabernaemontana catharinensis (Apocynaceae).

Authors:  Milena S Gonçalves; Ivo J Curcino Vieira; Rodrigo R Oliveira; Raimundo Braz-Filho
Journal:  Molecules       Date:  2011-09-02       Impact factor: 4.411

10.  An automated haematology analyzer XN-30 distinguishes developmental stages of falciparum malaria parasite cultured in vitro.

Authors:  Takahiro Tougan; Yuhgi Suzuki; Sawako Itagaki; Munehisa Izuka; Yuji Toya; Kinya Uchihashi; Toshihiro Horii
Journal:  Malar J       Date:  2018-02-02       Impact factor: 2.979
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  3 in total

1.  Chukranoids A-I, isopimarane diterpenoids from Chukrasia velutina.

Authors:  Alfarius Eko Nugroho; Masaki Tange; Sumi Kusakabe; Yusuke Hirasawa; Osamu Shirota; Michiyo Matsuno; Hajime Mizukami; Takahiro Tougan; Toshihiro Horii; Hiroshi Morita
Journal:  J Nat Med       Date:  2022-05-05       Impact factor: 3.192

Review 2.  Alkaloids from Plants with Antimalarial Activity: A Review of Recent Studies.

Authors:  Philip F Uzor
Journal:  Evid Based Complement Alternat Med       Date:  2020-02-12       Impact factor: 2.629

3.  Two new bisindole alkaloids from Tabernaemontana macrocarpa Jack.

Authors:  Puteri Amelia; Alfarius Eko Nugroho; Yusuke Hirasawa; Toshio Kaneda; Takahiro Tougan; Toshihiro Horii; Hiroshi Morita
Journal:  J Nat Med       Date:  2021-04-06       Impact factor: 2.343
  3 in total

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