| Literature DB >> 30362746 |
Alfarius Eko Nugroho1, Wenjia Zhang1, Yusuke Hirasawa1, Yiming Tang1, Chin Piow Wong1, Toshio Kaneda1, A Hamid A Hadi2, Hiroshi Morita1.
Abstract
Three new bisindole alkaloids, bisleuconothines B-D (1-3), were isolated from the bark of Leuconotis griffithii. Their structures were elucidated by 1D and 2D NMR spectroscopy and DFT calculations. Bisleuconothine B (1) is the first monoterpene indole alkaloid dimer featuring bridges between both C-16-C-10' and C-2-O-C-9'. All compounds were deemed noncytotoxic (IC50 > 10 μM) when tested against A549 human lung adenocarcinoma cells.Entities:
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Year: 2018 PMID： 30362746 DOI： 10.1021/acs.jnatprod.8b00749
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050