Literature DB >> 30204125

Shared-photodetector readout to improve the sensitivity of positron emission tomography.

Junwei Du1, Peng Peng, Xiaowei Bai, Simon R Cherry.   

Abstract

Sensitivity is an important performance characteristic of positron emission tomography (PET) systems. Improved sensitivity can be used to reduce injected dose, reduce scan time, or improve the signal-to-noise ratio and temporal resolution for dynamic studies. One way to improve the sensitivity of PET scanners is to reduce the gaps between detector modules. In this paper, a new signal processing method, named the shared-photodetector readout method, is proposed and evaluated. In this method, the signals generated in nearest neighbor photodetectors adjacent to the detector module of interest, were used to help identify the interaction location in the detector module of interest. Using this method, scintillator array-based detector modules with almost 100% packing fraction can be built, and the edge crystals can be clearly resolved, even when the crystals are small compared to the photodetector size. To evaluate this signal processing concept in one dimension, a detector block with four dual-ended readout detector modules, was designed. The detector block consisted of eight 4  ×  4 arrays of SensL MicroFJ-30035 SiPMs coupled to both ends of a 14  ×  56 array of 0.9  ×  0.9  ×  20 mm3 LYSO elements with a pitch size of 0.96 mm and a length of 20 mm. Performance in terms of energy resolution, flood histogram, timing resolution and depth-of-interaction resolution obtained using the shared-photodetector readout method were compared to those obtained using a conventional readout method. The results show that better over-all performance was achieved using the shared-photodetector readout method, especially at the edges and corners of the array.

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Year:  2018        PMID: 30204125      PMCID: PMC6234418          DOI: 10.1088/1361-6560/aae056

Source DB:  PubMed          Journal:  Phys Med Biol        ISSN: 0031-9155            Impact factor:   3.609


  11 in total

1.  Depth of interaction calibration for PET detectors with dual-ended readout by PSAPDs.

Authors:  Yongfeng Yang; Jinyi Qi; Yibao Wu; Sara St James; Richard Farrell; Purushottam A Dokhale; Kanai S Shah; Simon R Cherry
Journal:  Phys Med Biol       Date:  2008-12-19       Impact factor: 3.609

2.  Effects of reflector and crystal surface on the performance of a depth-encoding PET detector with dual-ended readout.

Authors:  Silin Ren; Yongfeng Yang; Simon R Cherry
Journal:  Med Phys       Date:  2014-07       Impact factor: 4.071

3.  A method to achieve spatial linearity and uniform resolution at the edges of monolithic scintillation crystal detectors.

Authors:  Ruud Vinke; Craig S Levin
Journal:  Phys Med Biol       Date:  2014-05-19       Impact factor: 3.609

4.  Optimization of an ultralow-dose high-resolution pediatric PET scanner design based on monolithic scintillators with dual-sided digital SiPM readout: a simulation study.

Authors:  Ekaterina Mikhaylova; Valerio Tabacchini; Giacomo Borghi; Pieter Mollet; Ester D'Hoe; Dennis R Schaart; Stefaan Vandenberghe
Journal:  Phys Med Biol       Date:  2017-10-19       Impact factor: 3.609

5.  A Prototype High-Resolution Small-Animal PET Scanner Dedicated to Mouse Brain Imaging.

Authors:  Yongfeng Yang; Julien Bec; Jian Zhou; Mengxi Zhang; Martin S Judenhofer; Xiaowei Bai; Kun Di; Yibao Wu; Mercedes Rodriguez; Purushottam Dokhale; Kanai S Shah; Richard Farrell; Jinyi Qi; Simon R Cherry
Journal:  J Nucl Med       Date:  2016-03-24       Impact factor: 10.057

6.  Simulation study of spatial resolution and sensitivity for the tapered depth of interaction PET detectors for small animal imaging.

Authors:  Sara St James; Yongfeng Yang; Spencer L Bowen; Jinyi Qi; Simon R Cherry
Journal:  Phys Med Biol       Date:  2009-12-21       Impact factor: 3.609

7.  Performance of a high-resolution depth-encoding PET detector module using linearly-graded SiPM arrays.

Authors:  Junwei Du; Xiaowei Bai; Alberto Gola; Fabio Acerbi; Alessandro Ferri; Claudio Piemonte; Yongfeng Yang; Simon R Cherry
Journal:  Phys Med Biol       Date:  2018-02-05       Impact factor: 3.609

Review 8.  Update on time-of-flight PET imaging.

Authors:  Suleman Surti
Journal:  J Nucl Med       Date:  2014-12-18       Impact factor: 10.057

Review 9.  Total-Body PET: Maximizing Sensitivity to Create New Opportunities for Clinical Research and Patient Care.

Authors:  Simon R Cherry; Terry Jones; Joel S Karp; Jinyi Qi; William W Moses; Ramsey D Badawi
Journal:  J Nucl Med       Date:  2017-09-21       Impact factor: 10.057

10.  Characterization of Large-Area SiPM Array for PET Applications.

Authors:  Junwei Du; Yongfeng Yang; Xiaowei Bai; Martin S Judenhofer; Eric Berg; Kun Di; Steve Buckley; Carl Jackson; Simon R Cherry
Journal:  IEEE Trans Nucl Sci       Date:  2016-02-15       Impact factor: 1.679

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