| Literature DB >> 29914645 |
Jasmina Radoicic1, Sang Ho Park1, Stanley J Opella2.
Abstract
Macrodiscs, which are magnetically alignable lipid bilayer discs with diameters of >30 nm, were obtained by solubilizing protein-containing liposomes with styrene-maleic acid copolymers. Macrodiscs provide a detergent-free phospholipid bilayer environment for biophysical and functional studies of membrane proteins under physiological conditions. The narrow resonance linewidths observed from membrane proteins in styrene-maleic acid macrodiscs advance structure determination by oriented sample solid-state NMR spectroscopy.Entities:
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Year: 2018 PMID: 29914645 PMCID: PMC6035293 DOI: 10.1016/j.bpj.2018.05.024
Source DB: PubMed Journal: Biophys J ISSN: 0006-3495 Impact factor: 4.033