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Literature DB >> 2892779

Apolipoprotein gene cluster on chromosome 19. Definite localization of the APOC2 gene and the polymorphic Hpa I site associated with type III hyperlipoproteinemia.

M Smit¹, E van der Kooij-Meijs, R R Frants, L Havekes, E C Klasen.

Abstract

Recently, using an APOE cDNA probe, we discovered an Hpa I restriction fragment length polymorphism (RFLP) that appeared to be strongly associated with the expression of type III hyperlipoproteinemia (Klasen et al. 1987). In the present report it is shown that the same Hpa I RFLP can be revealed with both the APOC1 and APOC2 cDNA probes. This enabled us to localize the polymorphic Hpa I site between the APOE and APOC1 genes and to localize the APOC2 gene approximately 22 kb 3' of the APOC1 pseudogene on chromosome 19.

Entities: Disease Gene

Mesh：

Substances：

Year: 1988 PMID： 2892779 DOI： 10.1007/bf00291243

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

21 in total

1. The isolation and characterization of cDNA clones for human apolipoprotein CII.

Authors: O Myklebost; B Williamson; A F Markham; S R Myklebost; J Rogers; D E Woods; S E Humphries
Journal: J Biol Chem Date: 1984-04-10 Impact factor: 5.157

2. The human thyroglobulin gene contains two 15-17 kb introns near its 3'-end.

Authors: G J van Ommen; A C Arnberg; F Baas; H Brocas; A Sterk; W H Tegelaers; G Vassart; J J de Vijlder
Journal: Nucleic Acids Res Date: 1983-04-25 Impact factor: 16.971

3. There are two gene sequences for human apolipoprotein CI (apo CI) on chromosome 19, one of which is 4 kb from the gene for apo E.

Authors: P J Davison; P Norton; S C Wallis; L Gill; M Cook; R Williamson; S E Humphries
Journal: Biochem Biophys Res Commun Date: 1986-05-14 Impact factor: 3.575

4. Synthesis, intracellular processing, and signal peptide of human apolipoprotein E.

Authors: V I Zannis; J McPherson; G Goldberger; S K Karathanasis; J L Breslow
Journal: J Biol Chem Date: 1984-05-10 Impact factor: 5.157

5. Characterisation of mRNAs encoding the precursor for human apolipoprotein CI.

Authors: T J Knott; M E Robertson; L M Priestley; M Urdea; S Wallis; J Scott
Journal: Nucleic Acids Res Date: 1984-05-11 Impact factor: 16.971

6. The locus for apolipoprotein CII is closely linked to the apolipoprotein E locus on chromosome 19 in man.

Authors: O Myklebost; S Rogne; B Olaisen; T Gedde-Dahl; H Prydz
Journal: Hum Genet Date: 1984 Impact factor: 4.132

7. The locus for apolipoprotein E (apoE) is linked to the complement component C3 (C3) locus on chromosome 19 in man.

Authors: B Olaisen; P Teisberg; T Gedde-Dahl
Journal: Hum Genet Date: 1982 Impact factor: 4.132

8. A common restriction fragment length polymorphism of the human apolipoprotein E gene and its relationship to type III hyperlipidaemia.

Authors: E C Klasen; P J Talmud; L Havekes; E de Wit; E van der Kooij-Meijs; M Smit; G Hansson; S E Humphries
Journal: Hum Genet Date: 1987-03 Impact factor: 4.132

9. The gene for apolipoprotein C-II is closely linked to the gene for apolipo-protein E on chromosome 19.

Authors: S E Humphries; K Berg; L Gill; A M Cumming; F W Robertson; A F Stalenhoef; R Williamson; A L Børresen
Journal: Clin Genet Date: 1984-11 Impact factor: 4.438

10. Linkage relationships of the gene for apolipoprotein CII with loci on chromosome 19.

Authors: J A Donald; S C Wallis; A Kessling; P Tippett; E B Robson; S Ball; K E Davies; P Scambler; K Berg; A Heiberg
Journal: Hum Genet Date: 1985 Impact factor: 4.132

22 in total

1. Extended haplotypes and linkage disequilibrium between 11 markers at the APOA1-C3-A4 gene cluster on chromosome 11.

Authors: P Benlian; C Boileau; N Loux; D Pastier; J Masliah; M Coulon; M Nigou; A Ragab; J Guimard; J B Ruidavets
Journal: Am J Hum Genet Date: 1991-05 Impact factor: 11.025

2. Use of variable simple sequence motifs as genetic markers: application to study of myotonic dystrophy.

Authors: H J Smeets; H G Brunner; H H Ropers; B Wieringa
Journal: Hum Genet Date: 1989-10 Impact factor: 4.132

3. Apolipoprotein (apo) E genotypes by polymerase chain reaction and allele-specific oligonucleotide probes: no detectable linkage disequilibrium between apo E and apo CII.

Authors: R S Houlston; C Snowden; F Green; K G Alberti; S E Humphries
Journal: Hum Genet Date: 1989-11 Impact factor: 4.132

4. Genetic Variation of ApoE Gene in Ethnic Kashmiri Population and Its Association with Outcome After Traumatic Brain Injury.

Authors: Adfar Yousuf; Nayil Khursheed; Ishrat Rasool; Vijay Kundal; Humira Jeelani; Dil Afroze
Journal: J Mol Neurosci Date: 2015-04-10 Impact factor: 3.444

Review 5. The relationship between high density lipoprotein subclass profile and apolipoprotein concentrations.

Authors: L Tian; M Fu
Journal: J Endocrinol Invest Date: 2011-06 Impact factor: 4.256

6. Macrophage-specific up-regulation of apolipoprotein E gene expression by STAT1 is achieved via long range genomic interactions.

Authors: Violeta Georgeta Trusca; Elena Valeria Fuior; Irina Cristina Florea; Dimitris Kardassis; Maya Simionescu; Anca Violeta Gafencu
Journal: J Biol Chem Date: 2011-03-03 Impact factor: 5.157