Literature DB >> 6304645

The human thyroglobulin gene contains two 15-17 kb introns near its 3'-end.

G J van Ommen, A C Arnberg, F Baas, H Brocas, A Sterk, W H Tegelaers, G Vassart, J J de Vijlder.   

Abstract

We have cloned overlapping segments of the human thyroglobulin gene from a genomic cosmid library. Restriction mapping and electron microscopy show that a region of 38 kb at or near the 3'-end of this gene encodes only 850 nucleotides or 10% of the messenger RNA (mRNA) sequence. The region contains five exons of 130-210 nucleotides, split by introns of 1 to 15-17 kb. This represents the lowest ratio of coding to non-coding DNA (2.2%) found thus far in any eukaryotic gene. Blot hybridization under non-stringent conditions shows the presence of only one copy of this gene in the human genome and the absence of other closely related sequences.

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Year:  1983        PMID： 6304645      PMCID： PMC325883          DOI： 10.1093/nar/11.8.2273

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  25 in total

1.  Control of thyroglobulin synthesis and secretion. (First of two parts).

Authors:  A J Van Herle; G Vassart; J E Dumont
Journal:  N Engl J Med       Date:  1979-08-02       Impact factor: 91.245

2.  Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors:  E M Southern
Journal:  J Mol Biol       Date:  1975-11-05       Impact factor: 5.469

3.  Cloning of hormone genes from a mixture of cDNA molecules.

Authors:  H M Goodman; R J MacDonald
Journal:  Methods Enzymol       Date:  1979       Impact factor: 1.600

4.  Base pairing and fidelity in codon-anticodon interaction.

Authors:  M D Topal; J R Fresco
Journal:  Nature       Date:  1976-09-23       Impact factor: 49.962

5.  Molecular weight of the thyroglobulin messenger RNA of sheep thyroid gland.

Authors:  J Chebath; O Chabaud; J L Bergé-Lefranc; G Cartouzou; S Lissitzky
Journal:  Biochem Biophys Res Commun       Date:  1977-11-07       Impact factor: 3.575

6.  Plasmid vehicles for direct cloning of Escherichia coli promoters.

Authors:  G An; J D Friesen
Journal:  J Bacteriol       Date:  1979-11       Impact factor: 3.490

7.  Preferential syntheisi of thyroxine from early iodinated tyrosyl residues in thyroglobulin.

Authors:  L Lamas; A Taurog; G Salvatore; H Edelhoch
Journal:  J Biol Chem       Date:  1974-05-10       Impact factor: 5.157

8.  Some yeast mitochondrial RNAs are circular.

Authors:  A C Arnberg; G J Van Ommen; L A Grivell; E F Van Bruggen; P Borst
Journal:  Cell       Date:  1980-02       Impact factor: 41.582

9.  Polypeptide chains of 19-S thyroglobulin from several mammalian species and of porcine 27-S iodoprotein.

Authors:  C Marriq; M Rolland; S Lissitzky
Journal:  Eur J Biochem       Date:  1977-09-15

10.  A membrane-filter technique for the detection of complementary DNA.

Authors:  D T Denhardt
Journal:  Biochem Biophys Res Commun       Date:  1966-06-13       Impact factor: 3.575
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  27 in total

1.  Unusual X chromosome inactivation in a mentally retarded girl with an interstitial deletion Xq27: implications for the fragile X syndrome.

Authors:  M Schmidt; A Certoma; D Du Sart; P Kalitsis; M Leversha; K Fowler; L Sheffield; I Jack; D M Danks
Journal:  Hum Genet       Date:  1990-03       Impact factor: 4.132

2.  Alpha 1-antitrypsin deficiency caused by the alpha 1-antitrypsin Nullmattawa gene. An insertion mutation rendering the alpha 1-antitrypsin gene incapable of producing alpha 1-antitrypsin.

Authors:  D Curiel; M Brantly; E Curiel; L Stier; R G Crystal
Journal:  J Clin Invest       Date:  1989-04       Impact factor: 14.808

3.  A Pro----Leu substitution in codon 369 of the alpha-1-antitrypsin deficiency variant PI MHeerlen.

Authors:  M H Hofker; T Nukiwa; H M van Paassen; M Nelen; J A Kramps; E C Klasen; R R Frants; R G Crystal
Journal:  Hum Genet       Date:  1989-02       Impact factor: 4.132

4.  In-frame single codon deletion in the Mmalton deficiency allele of alpha 1-antitrypsin.

Authors:  G C Fraizer; T R Harrold; M H Hofker; D W Cox
Journal:  Am J Hum Genet       Date:  1989-06       Impact factor: 11.025

5.  The complete structure of the rat thyroglobulin gene.

Authors:  A M Musti; E V Avvedimento; C Polistina; V M Ursini; S Obici; L Nitsch; S Cocozza; R Di Lauro
Journal:  Proc Natl Acad Sci U S A       Date:  1986-01       Impact factor: 11.205

6.  Origin of noncoding DNA sequences: molecular fossils of genome evolution.

Authors:  H Naora; K Miyahara; R N Curnow
Journal:  Proc Natl Acad Sci U S A       Date:  1987-09       Impact factor: 11.205

7.  Localization of the thyroglobulin gene by in situ hybridization to human chromosomes.

Authors:  J L Bergé-Lefranc; G Cartouzou; M G Mattéi; E Passage; C Malezet-Desmoulins; S Lissitzky
Journal:  Hum Genet       Date:  1985       Impact factor: 4.132

8.  Efficient isolation of X chromosome-specific single-copy probes from a cosmid library of a human X/hamster hybrid-cell line: mapping of new probes close to the locus for X-linked mental retardation.

Authors:  M H Hofker; A A Bergen; M I Skraastad; N J Carpenter; H Veenema; J M Connor; E Bakker; G J van Ommen; P L Pearson
Journal:  Am J Hum Genet       Date:  1987-04       Impact factor: 11.025

9.  Structural organization of the 3' half of the rat thyroglobulin gene.

Authors:  V E Avvedimento; A M Musti; S Obici; S Cocozza; R Di Lauro
Journal:  Nucleic Acids Res       Date:  1984-04-25       Impact factor: 16.971

10.  Unusual scarcity of restriction site polymorphism in the human thyroglobulin gene. A linkage study suggesting autosomal dominance of a defective thyroglobulin allele.

Authors:  F Baas; H Bikker; G J van Ommen; J J de Vijlder
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132
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