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Literature DB >> 7169215

The locus for apolipoprotein E (apoE) is linked to the complement component C3 (C3) locus on chromosome 19 in man.

Abstract

By two-dimensional electrophoresis of human serum a genetically determined polymorphism of apolipoprotein E (apoE) can be demonstrated. Three alleles occur with appreciable frequency in Caucasian populations. In the present study the segregation of apoE and complement component C3 (C3) types in material from Norwegian families has been studied. Linkage has convincingly been demonstrated between the two loci with a lod score of 3.00 in males at a recombination fraction of 13%. As it is known that the C3 locus is situated on chromosome 19 in man, apoE can be located to this specific chromosome. Positive linkage data do not, to our knowledge, at present exist with regard to other apolipoproteins.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1982 PMID： 7169215 DOI： 10.1007/bf00333526

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

14 in total

1. Sequential tests for the detection of linkage.

Authors: N E MORTON
Journal: Am J Hum Genet Date: 1955-09 Impact factor: 11.025

2. Heterogeneity of human plasma very low density lipoproteins. Separation of species differing in protein components.

Authors: V G Shore; B Shore
Journal: Biochemistry Date: 1973-01-30 Impact factor: 3.162

3. High voltage agarose gel electrophoresis in the study of C 3 polymorphism.

Authors: P Teisberg
Journal: Vox Sang Date: 1970-07 Impact factor: 2.144

4. Linkage between familial hypercholesterolemia with xanthomatosis and the C3 polymorphism confirmed.

Authors: K Berg; A Heiberg
Journal: Cytogenet Cell Genet Date: 1978

5. Analytical techniques for cell fractions. XXII. Two-dimensional analysis of serum and tissue proteins: multiple gradient-slab gel electrophoresis.

Authors: N L Anderson; N G Anderson
Journal: Anal Biochem Date: 1978-04 Impact factor: 3.365

6. Linkage studies in a large kindred with familial hypercholesterolemia.

Authors: J Ott; H G Schrott; J L Goldstein; W R Hazzard; F H Allen; C T Falk; A G Motulsky
Journal: Am J Hum Genet Date: 1974-09 Impact factor: 11.025

7. Human E apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms.

Authors: K H Weisgraber; S C Rall; R W Mahley
Journal: J Biol Chem Date: 1981-09-10 Impact factor: 5.157

8. The apoE polymorphism studied by two-dimensional, high-resolution gel electrophoresis of serum.

Authors: A L Børresen; K Berg
Journal: Clin Genet Date: 1981-12 Impact factor: 4.438

9. Two-dimensional gel electrophoresis of serum specimens from a normal population.

Authors: R P Tracy; R M Currie; D S Young
Journal: Clin Chem Date: 1982-04 Impact factor: 8.327

10. Human apolipoprotein E isoprotein subclasses are genetically determined.

Authors: V I Zannis; P W Just; J L Breslow
Journal: Am J Hum Genet Date: 1981-01 Impact factor: 11.025

35 in total

Review 1. Genes other than BRCA1 and BRCA2 involved in breast cancer susceptibility.

Authors: M M de Jong; I M Nolte; G J te Meerman; W T A van der Graaf; J C Oosterwijk; J H Kleibeuker; M Schaapveld; E G E de Vries
Journal: J Med Genet Date: 2002-04 Impact factor: 6.318

Review 2. Gene mapping and chromosome 19.

Authors: D J Shaw; J D Brook; A L Meredith; H G Harley; M Sarfarazi; P S Harper
Journal: J Med Genet Date: 1986-02 Impact factor: 6.318

3. Apolipoprotein (apo) E genotypes by polymerase chain reaction and allele-specific oligonucleotide probes: no detectable linkage disequilibrium between apo E and apo CII.

Authors: R S Houlston; C Snowden; F Green; K G Alberti; S E Humphries
Journal: Hum Genet Date: 1989-11 Impact factor: 4.132

4. A physical map of the apolipoprotein gene cluster on human chromosome 19.

Authors: O Myklebost; S Rogne
Journal: Hum Genet Date: 1988-03 Impact factor: 4.132

Review 5. Genomic variants, genes, and pathways of Alzheimer's disease: An overview.

Authors: Adam C Naj; Gerard D Schellenberg
Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2017-01 Impact factor: 3.568

6. Isolation and sequence of a human apolipoprotein CII cDNA clone and its use to isolate and map to human chromosome 19 the gene for apolipoprotein CII.

Authors: C L Jackson; G A Bruns; J L Breslow
Journal: Proc Natl Acad Sci U S A Date: 1984-05 Impact factor: 11.205

10. Human apolipoprotein E expression in Escherichia coli: structural and functional identity of the bacterially produced protein with plasma apolipoprotein E.

Authors: T Vogel; K H Weisgraber; M I Zeevi; H Ben-Artzi; A Z Levanon; S C Rall; T L Innerarity; D Y Hui; J M Taylor; D Kanner
Journal: Proc Natl Acad Sci U S A Date: 1985-12 Impact factor: 11.205