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Literature DB >> 6546757

The isolation and characterization of cDNA clones for human apolipoprotein CII.

O Myklebost, B Williamson, A F Markham, S R Myklebost, J Rogers, D E Woods, S E Humphries.

Abstract

Recombinant clones containing cDNA sequences coding for human apolipoprotein CII have been isolated from a human adult liver cDNA library. The clones were detected by hybridization with a mixed probe consisting of 96 different oligonucleotides 17 bases long, complementary to the mRNA coding for amino acids 66 to 71 of apolipoprotein CII. The largest cDNA insert is 439 nucleotides long and contains the complete sequence for the mature protein, the 3' untranslated sequence, and sequence coding for 17 amino acids of a signal peptide. The cDNA clone was used to detect apolipoprotein CII mRNA approximately 500 bases long in human liver and intestine RNA.

Entities: Chemical Gene Species

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Year: 1984 PMID： 6546757

Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157

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Cited

29 in total

1. The physical map of chromosome arm 19q: some new assignments, confirmations and re-assessments.

Authors: J D Brook; S J Knight; S H Roberts; H G Harley; K V Walsh; S A Rundle; K Freyne; M C Koch; N D Epstein; B Wieringa
Journal: Hum Genet Date: 1991-05 Impact factor: 4.132

2. Association analysis of lipid levels and apolipoprotein restriction fragment length polymorphisms.

Authors: O Myklebost; S Rogne; I Hjermann; B Olaisen; H Prydz
Journal: Hum Genet Date: 1990-12 Impact factor: 4.132

3. Apolipoprotein (apo) E genotypes by polymerase chain reaction and allele-specific oligonucleotide probes: no detectable linkage disequilibrium between apo E and apo CII.

Authors: R S Houlston; C Snowden; F Green; K G Alberti; S E Humphries
Journal: Hum Genet Date: 1989-11 Impact factor: 4.132

4. Purification, cloning and nucleotide sequence determination of cynomolgus monkey apolipoprotein C-II: comparison to the human sequence.

Authors: B E Whitted; C K Castle; H G Polites; G W Melchior; K R Marotti
Journal: Mol Cell Biochem Date: 1989-10-05 Impact factor: 3.396

The isolation and characterization of cDNA clones for human apolipoprotein CII.

1. The physical map of chromosome arm 19q: some new assignments, confirmations and re-assessments.

2. Association analysis of lipid levels and apolipoprotein restriction fragment length polymorphisms.

3. Apolipoprotein (apo) E genotypes by polymerase chain reaction and allele-specific oligonucleotide probes: no detectable linkage disequilibrium between apo E and apo CII.

4. Purification, cloning and nucleotide sequence determination of cynomolgus monkey apolipoprotein C-II: comparison to the human sequence.

5. A model system for the analysis of gene exclusion: cystic fibrosis and chromosome 19.

6. A physical map of the apolipoprotein gene cluster on human chromosome 19.

7. Regional localisations and linkage relationships of seven RFLPs and myotonic dystrophy on chromosome 19.

8. Myotonic dystrophy is closely linked to the gene for muscle-type creatine kinase (CKMM).

9. The locus for apolipoprotein CII is closely linked to the apolipoprotein E locus on chromosome 19 in man.

10. Apolipoprotein CIISt. Michael. Familial apolipoprotein CII deficiency associated with premature vascular disease.