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Literature DB >> 6328444

Characterisation of mRNAs encoding the precursor for human apolipoprotein CI.

T J Knott, M E Robertson, L M Priestley, M Urdea, S Wallis, J Scott.

Abstract

cDNA clones encoding human apolipoprotein CI have been isolated from an adult liver cDNA library. Apo CI mRNA was shown to have two species of approximately 580 and 560 bases by RNA blot hybridisation. The intracellular precursor of apo CI was inferred from the cDNA sequence to be an 83 amino acid polypeptide consisting of the 57 residue mature protein and an additional 26 residue amino terminal signal peptide. The 5' untranslated regions of the messages are 63 and 40 bases as determined by primer extension and the 3' untranslated region 111 bases. A polyadenylation signal is situated 10 bases 3' of the poly(A) tall. The mRNA level of apo CI in human liver was significantly greater than that of apo All and apo E.

Entities: Gene Species

Mesh：

Substances：

Year: 1984 PMID： 6328444 PMCID： PMC318798 DOI： 10.1093/nar/12.9.3909

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

22 in total

1. Effect of the human plasma apolipoproteins and phosphatidylcholine acyl donor on the activity of lecithin: cholesterol acyltransferase.

Authors: A K Soutar; C W Garner; H N Baker; J T Sparrow; R L Jackson; A M Gotto; L C Smith
Journal: Biochemistry Date: 1975-07-15 Impact factor: 3.162

2. Thf complete amino acid sequence of C-I (apoLp-Ser), an apolipoprotein from human very low density lipoproteins.

Authors: R S Shulman; P N Herbert; K Wehrly; D S Fredrickson
Journal: J Biol Chem Date: 1975-01-10 Impact factor: 5.157

3. Nature of Col E 1 plasmid replication in Escherichia coli in the presence of the chloramphenicol.

Authors: D B Clewell
Journal: J Bacteriol Date: 1972-05 Impact factor: 3.490

4. Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.

Authors: P S Thomas
Journal: Proc Natl Acad Sci U S A Date: 1980-09 Impact factor: 11.205

5. Specificity of oligo (dT)-cellulose chromatography in the isolation of polyadenylated RNA.

Authors: J A Bantle; I H Maxwell; W E Hahn
Journal: Anal Biochem Date: 1976-05-07 Impact factor: 3.365

6. Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing.

Authors: F Sanger; A R Coulson; B G Barrell; A J Smith; B A Roe
Journal: J Mol Biol Date: 1980-10-25 Impact factor: 5.469

7. Sequencing end-labeled DNA with base-specific chemical cleavages.

Authors: A M Maxam; W Gilbert
Journal: Methods Enzymol Date: 1980 Impact factor: 1.600

8. Evolution of lipoproteins deduced from protein sequence data.

Authors: W C Barker; M O Dayhoff
Journal: Comp Biochem Physiol B Date: 1977

9. Effect of human plasma apolipoproteins on the activity of purified lecithin: cholesterol acyltransferase.

Authors: J J Albers; J Lin; G P Roberts
Journal: Artery Date: 1979-01

10. Cloning of influenza cDNA ino M13: the sequence of the RNA segment encoding the A/PR/8/34 matrix protein.

Authors: G Winter; S Fields
Journal: Nucleic Acids Res Date: 1980-05-10 Impact factor: 16.971

11 in total

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Authors: N S Shachter; T Ebara; R Ramakrishnan; G Steiner; J L Breslow; H N Ginsberg; J D Smith
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2. Nucleotide sequence of cDNA for rat apolipoprotein C-I.

Authors: P Y Shen; G J Howlett
Journal: Nucleic Acids Res Date: 1989-08-11 Impact factor: 16.971

3. A physical map of the apolipoprotein gene cluster on human chromosome 19.

Authors: O Myklebost; S Rogne
Journal: Hum Genet Date: 1988-03 Impact factor: 4.132

4. Isolation and characterisation of a cDNA clone for human apolipoprotein CI and assignment of the gene to chromosome 19.

Authors: F Tata; I Henry; A F Markham; S C Wallis; D Weil; K H Grzeschik; C Junien; R Williamson; S E Humphries
Journal: Hum Genet Date: 1985 Impact factor: 4.132

5. Increased response to cholesterol feeding in apolipoprotein C1-deficient mice.

Authors: J H van Ree; M H Hofker; W J van den Broek; J M van Deursen; H van der Boom; R R Frants; B Wieringa; L M Havekes
Journal: Biochem J Date: 1995-02-01 Impact factor: 3.857

6. Human apolipoprotein B cDNA clone isolation and demonstration that liver apolipoprotein B mRNA is 22 kilobases in length.

Authors: L S Huang; S C Bock; S I Feinstein; J L Breslow
Journal: Proc Natl Acad Sci U S A Date: 1985-10 Impact factor: 11.205

7. Localization of genes encoding apolipoproteins CI, CII, and E to the p13----cen region of human chromosome 19.

Authors: J Scott; T J Knott; D J Shaw; J D Brook
Journal: Hum Genet Date: 1985 Impact factor: 4.132

8. Apolipoprotein gene cluster on chromosome 19. Definite localization of the APOC2 gene and the polymorphic Hpa I site associated with type III hyperlipoproteinemia.

Authors: M Smit; E van der Kooij-Meijs; R R Frants; L Havekes; E C Klasen
Journal: Hum Genet Date: 1988-01 Impact factor: 4.132

9. Regional mapping of human chromosome 19: organization of genes for plasma lipid transport (APOC1, -C2, and -E and LDLR) and the genes C3, PEPD, and GPI.

Authors: A J Lusis; C Heinzmann; R S Sparkes; J Scott; T J Knott; R Geller; M C Sparkes; T Mohandas
Journal: Proc Natl Acad Sci U S A Date: 1986-06 Impact factor: 11.205

10. Linkage relationships of the apolipoprotein C1 gene and a cytochrome P450 gene (CYP2A) to myotonic dystrophy.

Authors: K V Walsh; H G Harley; J D Brook; S A Rundle; M Sarfarazi; P S Harper; D J Shaw
Journal: Hum Genet Date: 1990-08 Impact factor: 4.132