Literature DB >> 6094053

The gene for apolipoprotein C-II is closely linked to the gene for apolipo-protein E on chromosome 19.

S E Humphries, K Berg, L Gill, A M Cumming, F W Robertson, A F Stalenhoef, R Williamson, A L Børresen.   

Abstract

We have used a common TaqI restriction fragment length polymorphism (RFLP) near the human apolipoprotein C-II (apoC-II) gene to study linkage with apolipoprotein E (apoE). The inheritance of the apoC-II RFLP was followed in seven families that were segregating for apoE protein variants. No recombinants were observed in 20 informative meioses, giving an overall lod score of greater than 4.0 at recombination fraction 0. We have also observed apparent linkage disequilibrium between apoE and the apoC-II RFLP. Taken together these results demonstrate that these two apolipoprotein genes are closely linked and confirm that the gene for apoC-II is on human chromosome 19.

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Year:  1984        PMID： 6094053

Source DB:  PubMed          Journal:  Clin Genet        ISSN： 0009-9163            Impact factor:   4.438


  19 in total

Review 1.  Gene mapping and chromosome 19.

Authors:  D J Shaw; J D Brook; A L Meredith; H G Harley; M Sarfarazi; P S Harper
Journal:  J Med Genet       Date:  1986-02       Impact factor: 6.318

2.  Apolipoprotein (apo) E genotypes by polymerase chain reaction and allele-specific oligonucleotide probes: no detectable linkage disequilibrium between apo E and apo CII.

Authors:  R S Houlston; C Snowden; F Green; K G Alberti; S E Humphries
Journal:  Hum Genet       Date:  1989-11       Impact factor: 4.132

3.  A physical map of the apolipoprotein gene cluster on human chromosome 19.

Authors:  O Myklebost; S Rogne
Journal:  Hum Genet       Date:  1988-03       Impact factor: 4.132

4.  Segregation of linked probes to myotonic dystrophy in a family demonstrating that 152 and APOC2 are on the same side of DM on 19q.

Authors:  K Johnson; E Nimmo; P Jones; M Weiss; M L Savontaus; M Anvret; R Bartlett; A Roses; D Shaw; P S Harper
Journal:  Hum Genet       Date:  1988-12       Impact factor: 4.132

5.  Isolation and characterisation of a cDNA clone for human apolipoprotein CI and assignment of the gene to chromosome 19.

Authors:  F Tata; I Henry; A F Markham; S C Wallis; D Weil; K H Grzeschik; C Junien; R Williamson; S E Humphries
Journal:  Hum Genet       Date:  1985       Impact factor: 4.132

6.  Human genes involved in cholesterol metabolism: chromosomal mapping of the loci for the low density lipoprotein receptor and 3-hydroxy-3-methylglutaryl-coenzyme A reductase with cDNA probes.

Authors:  V Lindgren; K L Luskey; D W Russell; U Francke
Journal:  Proc Natl Acad Sci U S A       Date:  1985-12       Impact factor: 11.205

7.  A common restriction fragment length polymorphism of the human apolipoprotein E gene and its relationship to type III hyperlipidaemia.

Authors:  E C Klasen; P J Talmud; L Havekes; E de Wit; E van der Kooij-Meijs; M Smit; G Hansson; S E Humphries
Journal:  Hum Genet       Date:  1987-03       Impact factor: 4.132

8.  The isolation of a genomic clone containing the apolipoprotein CII gene and the detection of linkage disequilibrium between two common DNA polymorphisms around the gene.

Authors:  S C Wallis; J A Donald; L A Forrest; R Williamson; S E Humphries
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

9.  Tight linkage between myotonic dystrophy and apolipoprotein E genes revealed with allele-specific oligonucleotides.

Authors:  B Smeets; J Poddighe; H Brunner; H H Ropers; B Wieringa
Journal:  Hum Genet       Date:  1988-09       Impact factor: 4.132

10.  Linkage relationships of the gene for apolipoprotein CII with loci on chromosome 19.

Authors:  J A Donald; S C Wallis; A Kessling; P Tippett; E B Robson; S Ball; K E Davies; P Scambler; K Berg; A Heiberg
Journal:  Hum Genet       Date:  1985       Impact factor: 4.132
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