Literature DB >> 27745969

ALKBH1-Mediated tRNA Demethylation Regulates Translation.

Fange Liu1, Wesley Clark2, Guanzheng Luo1, Xiaoyun Wang2, Ye Fu1, Jiangbo Wei1, Xiao Wang1, Ziyang Hao1, Qing Dai1, Guanqun Zheng2, Honghui Ma1, Dali Han1, Molly Evans2, Arne Klungland3, Tao Pan4, Chuan He5.   

Abstract

tRNA is a central component of protein synthesis and the cell signaling network. One salient feature of tRNA is its heavily modified status, which can critically impact its function. Here, we show that mammalian ALKBH1 is a tRNA demethylase. It mediates the demethylation of N1-methyladenosine (m1A) in tRNAs. The ALKBH1-catalyzed demethylation of the target tRNAs results in attenuated translation initiation and decreased usage of tRNAs in protein synthesis. This process is dynamic and responds to glucose availability to affect translation. Our results uncover reversible methylation of tRNA as a new mechanism of post-transcriptional gene expression regulation.
Copyright © 2016 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  ALKBH1; N(1)-methyladenosine (m(1)A); codon usage; dynamic tRNA modification; tRNA demethylase; tRNA demethylation; tRNA methylation; translation elongation; translation initiation; translation regulation

Mesh：

Substances：

Year:  2016        PMID： 27745969      PMCID： PMC5119773          DOI： 10.1016/j.cell.2016.09.038

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  77 in total

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