Literature DB >> 16155581

Structural basis for anticodon recognition by methionyl-tRNA synthetase.

Kotaro Nakanishi1, Yuri Ogiso, Takashi Nakama, Shuya Fukai, Osamu Nureki.   

Abstract

In the 2.7-A resolution crystal structure of methionyl-tRNA synthetase (MetRS) in complex with tRNA(Met) and a methionyl-adenylate analog, the tRNA anticodon loop is distorted to form a triple-base stack comprising C34, A35 and A38. A tryptophan residue stacks on C34 to extend the triple-base stack. In addition, C34 forms Watson-Crick-type hydrogen bonds with Arg357. This structure resolves the longstanding question of how MetRS specifically recognizes tRNA(Met).

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Year:  2005        PMID： 16155581     DOI： 10.1038/nsmb988

Source DB:  PubMed          Journal:  Nat Struct Mol Biol        ISSN： 1545-9985            Impact factor:   15.369


  35 in total

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