| Literature DB >> 26046440 |
Xiao Wang1, Boxuan Simen Zhao1, Ian A Roundtree2, Zhike Lu1, Dali Han1, Honghui Ma1, Xiaocheng Weng1, Kai Chen1, Hailing Shi1, Chuan He3.
Abstract
N(6)-methyladenosine (m(6)A) is the most abundant internal modification in mammalian mRNA. This modification is reversible and non-stoichiometric and adds another layer to the dynamic control of mRNA metabolism. The stability of m(6)A-modified mRNA is regulated by an m(6)A reader protein, human YTHDF2, which recognizes m(6)A and reduces the stability of target transcripts. Looking at additional functional roles for the modification, we find that another m(6)A reader protein, human YTHDF1, actively promotes protein synthesis by interacting with translation machinery. In a unified mechanism of m(6)A-based regulation in the cytoplasm, YTHDF2-mediated degradation controls the lifetime of target transcripts, whereas YTHDF1-mediated translation promotion increases translation efficiency, ensuring effective protein production from dynamic transcripts that are marked by m(6)A. Therefore, the m(6)A modification in mRNA endows gene expression with fast responses and controllable protein production through these mechanisms.Entities:
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Year: 2015 PMID： 26046440 PMCID： PMC4825696 DOI： 10.1016/j.cell.2015.05.014
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582