Literature DB >> 27423891

Characterization of fibril dynamics on three timescales by solid-state NMR.

Albert A Smith1, Emilie Testori1, Riccardo Cadalbert1, Beat H Meier2, Matthias Ernst3.   

Abstract

A multi-timescale analysis of the backbone dynamics of HET-s (218-289) fibrils is described based on multiple site-specific R 1 and R 1ρ data sets and S (2) measurements via REDOR for most backbone (15)N and (13)Cα nuclei. (15)N and (13)Cα data are fitted with motions at three timescales. Slow motion is found, indicating a global fibril motion. We further investigate the effect of (13)C-(13)C transfer in measurement of (13)Cα R 1. Finally, we show that it is necessary to go beyond the Redfield approximation for slow motions in order to obtain accurate numerical values for R 1ρ.

Keywords:  Dynamics; Fibrils; Magic-angle spinning; Relaxation; Solid-state NMR

Mesh：

Substances：

Year:  2016        PMID： 27423891     DOI： 10.1007/s10858-016-0047-8

Source DB:  PubMed          Journal:  J Biomol NMR        ISSN： 0925-2738            Impact factor:   2.835


  44 in total

1.  Measurement of site-specific 13C spin-lattice relaxation in a crystalline protein.

Authors:  Józef R Lewandowski; Julien Sein; Hans Jürgen Sass; Stephan Grzesiek; Martin Blackledge; Lyndon Emsley
Journal:  J Am Chem Soc       Date:  2010-06-23       Impact factor: 15.419

2.  High resolution 1H-detected solid-state NMR spectroscopy of protein aliphatic resonances: access to tertiary structure information.

Authors:  Sam Asami; Peter Schmieder; Bernd Reif
Journal:  J Am Chem Soc       Date:  2010-11-03       Impact factor: 15.419

3.  Quantitative analysis of backbone dynamics in a crystalline protein from nitrogen-15 spin-lattice relaxation.

Authors:  Nicolas Giraud; Martin Blackledge; Maurice Goldman; Anja Böckmann; Anne Lesage; François Penin; Lyndon Emsley
Journal:  J Am Chem Soc       Date:  2005-12-28       Impact factor: 15.419

4.  Probing water accessibility in HET-s(218-289) amyloid fibrils by solid-state NMR.

Authors:  Hélène Van Melckebeke; Paul Schanda; Julia Gath; Christian Wasmer; René Verel; Adam Lange; Beat H Meier; Anja Böckmann
Journal:  J Mol Biol       Date:  2010-11-19       Impact factor: 5.469

5.  Quantitative measurement of differential 15N-H(alpha/beta)T2 relaxation rates in a perdeuterated protein by MAS solid-state NMR spectroscopy.

Authors:  Veniamin Chevelkov; Anne Diehl; Bernd Reif
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6.  Characterization of different water pools in solid-state NMR protein samples.

Authors:  Anja Böckmann; Carole Gardiennet; René Verel; Andreas Hunkeler; Antoine Loquet; Guido Pintacuda; Lyndon Emsley; Beat H Meier; Anne Lesage
Journal:  J Biomol NMR       Date:  2009-11       Impact factor: 2.835

7.  De novo 3D structure determination from sub-milligram protein samples by solid-state 100 kHz MAS NMR spectroscopy.

Authors:  Vipin Agarwal; Susanne Penzel; Kathrin Szekely; Riccardo Cadalbert; Emilie Testori; Andres Oss; Jaan Past; Ago Samoson; Matthias Ernst; Anja Böckmann; Beat H Meier
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  27 in total

1.  Mechanistic Insights into Microsecond Time-Scale Motion of Solid Proteins Using Complementary 15N and 1H Relaxation Dispersion Techniques.

Authors:  Petra Rovó; Colin A Smith; Diego Gauto; Bert L de Groot; Paul Schanda; Rasmus Linser
Journal:  J Am Chem Soc       Date:  2019-01-08       Impact factor: 15.419

2.  Determination of methyl order parameters using solid state NMR under off magic angle spinning.

Authors:  Kai Xue; Salvatore Mamone; Benita Koch; Riddhiman Sarkar; Bernd Reif
Journal:  J Biomol NMR       Date:  2019-08-12       Impact factor: 2.835

3.  Solid-state NMR reveals a comprehensive view of the dynamics of the flexible, disordered N-terminal domain of amyloid-β fibrils.

Authors:  Dan Fai Au; Dmitry Ostrovsky; Riqiang Fu; Liliya Vugmeyster
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4.  Partially-deuterated samples of HET-s(218-289) fibrils: assignment and deuterium isotope effect.

Authors:  Albert A Smith; Francesco Ravotti; Emilie Testori; Riccardo Cadalbert; Matthias Ernst; Anja Böckmann; Beat H Meier
Journal:  J Biomol NMR       Date:  2017-01-10       Impact factor: 2.835

5.  INFOS: spectrum fitting software for NMR analysis.

Authors:  Albert A Smith
Journal:  J Biomol NMR       Date:  2017-02-03       Impact factor: 2.835

Review 6.  Insights into protein misfolding and aggregation enabled by solid-state NMR spectroscopy.

Authors:  Patrick C A van der Wel
Journal:  Solid State Nucl Magn Reson       Date:  2017-10-04       Impact factor: 2.293

7.  Microsecond Protein Dynamics from Combined Bloch-McConnell and Near-Rotary-Resonance R1p Relaxation-Dispersion MAS NMR.

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Journal:  Chemphyschem       Date:  2018-12-20       Impact factor: 3.102

Review 8.  Relaxing with liquids and solids - A perspective on biomolecular dynamics.

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Journal:  J Magn Reson       Date:  2019-07-11       Impact factor: 2.229

9.  Deuteron Solid-State NMR Relaxation Measurements Reveal Two Distinct Conformational Exchange Processes in the Disordered N-Terminal Domain of Amyloid-β Fibrils.

Authors:  Liliya Vugmeyster; Dan Fai Au; Dmitry Ostrovsky; Riqiang Fu
Journal:  Chemphyschem       Date:  2019-06-14       Impact factor: 3.102

10.  Conformational Dynamics in the Core of Human Y145Stop Prion Protein Amyloid Probed by Relaxation Dispersion NMR.

Authors:  Matthew D Shannon; Theint Theint; Dwaipayan Mukhopadhyay; Krystyna Surewicz; Witold K Surewicz; Dominique Marion; Paul Schanda; Christopher P Jaroniec
Journal:  Chemphyschem       Date:  2018-11-07       Impact factor: 3.102
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