Kristin J Cummings1, M Abbas Virji1, Ji Young Park1,2, Marcia L Stanton1, Nicole T Edwards1, Bruce C Trapnell3,4, Brenna Carey3, Aleksandr B Stefaniak1, Kathleen Kreiss1. 1. National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia. 2. Institute of Health and Environment, Seoul National University, Seoul, Republic of Korea. 3. Translational Pulmonary Science Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio. 4. Division of Pulmonary, Critical Care, and Sleep Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Abstract
BACKGROUND: Workers manufacturing indium-tin oxide (ITO) are at risk of elevated indium concentration in blood and indium lung disease, but relationships between respirable indium exposures and biomarkers of exposure and disease are unknown. METHODS: For 87 (93%) current ITO workers, we determined correlations between respirable and plasma indium and evaluated associations between exposures and health outcomes. RESULTS: Current respirable indium exposure ranged from 0.4 to 108 μg/m(3) and cumulative respirable indium exposure from 0.4 to 923 μg-yr/m(3) . Plasma indium better correlated with cumulative (rs = 0.77) than current exposure (rs = 0.54) overall and with tenure ≥1.9 years. Higher cumulative respirable indium exposures were associated with more dyspnea, lower spirometric parameters, and higher serum biomarkers of lung disease (KL-6 and SP-D), with significant effects starting at 22 μg-yr/m(3) , reached by 46% of participants. CONCLUSIONS: Plasma indium concentration reflected cumulative respirable indium exposure, which was associated with clinical, functional, and serum biomarkers of lung disease. Am. J. Ind. Med. 59:522-531, 2016. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. Published 2016. This article is a U.S. Government work and is in the public domain in the USA.
BACKGROUND: Workers manufacturing indium-tin oxide (ITO) are at risk of elevated indium concentration in blood and indiumlung disease, but relationships between respirable indium exposures and biomarkers of exposure and disease are unknown. METHODS: For 87 (93%) current ITO workers, we determined correlations between respirable and plasma indium and evaluated associations between exposures and health outcomes. RESULTS: Current respirable indium exposure ranged from 0.4 to 108 μg/m(3) and cumulative respirable indium exposure from 0.4 to 923 μg-yr/m(3) . Plasma indium better correlated with cumulative (rs = 0.77) than current exposure (rs = 0.54) overall and with tenure ≥1.9 years. Higher cumulative respirable indium exposures were associated with more dyspnea, lower spirometric parameters, and higher serum biomarkers of lung disease (KL-6 and SP-D), with significant effects starting at 22 μg-yr/m(3) , reached by 46% of participants. CONCLUSIONS: Plasma indium concentration reflected cumulative respirable indium exposure, which was associated with clinical, functional, and serum biomarkers of lung disease. Am. J. Ind. Med. 59:522-531, 2016. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. Published 2016. This article is a U.S. Government work and is in the public domain in the USA.
Authors: Kristin J Cummings; Walter E Donat; David B Ettensohn; Victor L Roggli; Peter Ingram; Kathleen Kreiss Journal: Am J Respir Crit Care Med Date: 2009-12-17 Impact factor: 21.405
Authors: T Hamaguchi; K Omae; T Takebayashi; Y Kikuchi; N Yoshioka; Y Nishiwaki; A Tanaka; M Hirata; O Taguchi; T Chonan Journal: Occup Environ Med Date: 2007-07-11 Impact factor: 4.402
Authors: Kristin J Cummings; Doug O Johns; Jacek M Mazurek; Frank J Hearl; David N Weissman Journal: Arch Environ Occup Health Date: 2018-12-02 Impact factor: 1.663
Authors: Brie Hawley Blackley; Jenna L Gibbs; Kristin J Cummings; Aleksandr B Stefaniak; Ji Young Park; Marcia Stanton; M Abbas Virji Journal: J Occup Environ Hyg Date: 2019-01-28 Impact factor: 2.155
Authors: Kirsten Anderson; Brenna Carey; Allison Martin; Christina Roark; Claudia Chalk; Marchele Nowell-Bostic; Brian Freed; Michael Aubrey; Bruce Trapnell; Andrew Fontenot Journal: PLoS One Date: 2019-03-07 Impact factor: 3.240
Authors: Ibrahim I Shabbaj; Hamada AbdElgawad; Mansour A Balkhyour; Abdurazag Tammar; Mahmoud M Y Madany Journal: Antioxidants (Basel) Date: 2022-02-03