OBJECTIVES: Two- and 13-week inhalation toxicities of indium-tin oxide (ITO) and indium oxide (IO) were characterized for risk assessments of workers exposed to ITO. METHODS: F344 rats of both sexes were exposed by inhalation to ITO or IO aerosol for 6 h/day, 5 day/wk for 2 wk at 0, 0.1, 1, 10 or 100 mg/m(3) or 13 wk at 0, 0.1 or 1 mg/m(3). An aerosol generator and inhalation exposure system was constructed. RESULTS: Blood and lung contents of indium were elevated in a dose-related manner in the ITO- and IO-exposed rats. ITO and IO particles were deposited in the lung, mediastinal lymph node and nasal-associated lymphoid tissue. Exposures to ITO and IO induced alveolar proteinosis, infiltrations of alveolar macrophages and inflammatory cells and alveolar epithelial hyperplasia in addition to increased lung weight. ITO affected the lung more severely than IO did. Fibrosis of alveolar wall developed and some of these lesions worsened at the end of the 26-week post-exposure period. CONCLUSIONS: Persistent pulmonary lesions including alveolar proteinosis and macrophage infiltration occurred after 2- and 13-week inhalation exposures of rats to ITO and IO. Fibrosis of alveolar wall developed later. These lesions occurred after ITO exposure at the same concentration as the current occupational exposure limit in the USA and at blood indium levels below the biological exposure index in Japan for indium.
OBJECTIVES: Two- and 13-week inhalation toxicities of indium-tin oxide (ITO) and indium oxide (IO) were characterized for risk assessments of workers exposed to ITO. METHODS: F344 rats of both sexes were exposed by inhalation to ITO or IO aerosol for 6 h/day, 5 day/wk for 2 wk at 0, 0.1, 1, 10 or 100 mg/m(3) or 13 wk at 0, 0.1 or 1 mg/m(3). An aerosol generator and inhalation exposure system was constructed. RESULTS: Blood and lung contents of indium were elevated in a dose-related manner in the ITO- and IO-exposed rats. ITO and IO particles were deposited in the lung, mediastinal lymph node and nasal-associated lymphoid tissue. Exposures to ITO and IO induced alveolar proteinosis, infiltrations of alveolar macrophages and inflammatory cells and alveolar epithelial hyperplasia in addition to increased lung weight. ITO affected the lung more severely than IO did. Fibrosis of alveolar wall developed and some of these lesions worsened at the end of the 26-week post-exposure period. CONCLUSIONS: Persistent pulmonary lesions including alveolar proteinosis and macrophage infiltration occurred after 2- and 13-week inhalation exposures of rats to ITO and IO. Fibrosis of alveolar wall developed later. These lesions occurred after ITO exposure at the same concentration as the current occupational exposure limit in the USA and at blood indium levels below the biological exposure index in Japan for indium.
Authors: Melissa A Badding; Natalie R Fix; Marlene S Orandle; Mark W Barger; Katherine M Dunnick; Kristin J Cummings; Stephen S Leonard Journal: J Appl Toxicol Date: 2015-10-15 Impact factor: 3.446
Authors: Kristin J Cummings; Makiko Nakano; Kazuyuki Omae; Koichiro Takeuchi; Tatsuya Chonan; Yong-Long Xiao; Russell A Harley; Victor L Roggli; Akira Hebisawa; Robert J Tallaksen; Bruce C Trapnell; Gregory A Day; Rena Saito; Marcia L Stanton; Eva Suarthana; Kathleen Kreiss Journal: Chest Date: 2011-12-29 Impact factor: 9.410
Authors: William M Gwinn; Wei Qu; Ronald W Bousquet; Herman Price; Cassandra J Shines; Genie J Taylor; Michael P Waalkes; Daniel L Morgan Journal: Toxicol Sci Date: 2014-12-19 Impact factor: 4.849
Authors: Cynthia J Hines; Jennifer L Roberts; Ronnee N Andrews; Matthew V Jackson; James A Deddens Journal: J Occup Environ Hyg Date: 2013 Impact factor: 2.155
Authors: Kristin J Cummings; M Abbas Virji; Ji Young Park; Marcia L Stanton; Nicole T Edwards; Bruce C Trapnell; Brenna Carey; Aleksandr B Stefaniak; Kathleen Kreiss Journal: Am J Ind Med Date: 2016-05-24 Impact factor: 2.214
Authors: Melissa A Badding; Diane Schwegler-Berry; Ju-Hyeong Park; Natalie R Fix; Kristin J Cummings; Stephen S Leonard Journal: PLoS One Date: 2015-04-13 Impact factor: 3.240