Roberta Matheoud1, Michela Lecchi2, Domenico Lizio1, Camilla Scabbio2, Claudio Marcassa3, Lucia Leva1, Angelo Del Sole2, Carlo Rodella4, Luca Indovina5, Christian Bracco6, Marco Brambilla7, Orazio Zoccarato2. 1. Departments of Medical Physics and Nuclear Medicine, University Hospital, Novara, Italy. 2. Department of Health Sciences, University of Milan and Nuclear Medicine Unit, San Paolo Hospital, Milan, Italy. 3. Unit of Nuclear Medicine and Department of Cardiology, S. Maugeri Foundation, IRCCS, Veruno, Italy. 4. Health Physics Unit, Spedali Civili Hospital, Brescia, Italy. 5. Department of Medical Physics, Polyclinic Agostino Gemelli, Rome, Italy. 6. Medical Physics Department, Institute for Cancer Research and Treatment, Candiolo, Italy. 7. Departments of Medical Physics and Nuclear Medicine, University Hospital, Novara, Italy. marco.brambilla@maggioreosp.novara.it.
Abstract
BACKGROUND: The purpose of this study was to evaluate the image quality in cardiac 18F-FDG PET using the time of flight (TOF) and/or point spread function (PSF) modeling in the iterative reconstruction (IR). METHODS: Three scanners and an anthropomorphic cardiac phantom with an insert simulating a transmural defect (TD) were used. Two sets of scans (with/without TD) were acquired, and four reconstruction schemes were considered: (1) IR; (2) IR + PSF, (3) IR + TOF, and (4) IR + TOF + PSF. LV wall thickness (FWHM), contrast between LV wall and inner chamber (C IC), and TD contrast in LV wall (C TD) were evaluated. RESULTS: Tests of the reconstruction protocols showed a decrease in FWHM from IR (13 mm) to IR + PSF (11 mm); an increase in the C IC from IR (65%) to IR + PSF (71%) and from IR + TOF (72%) to IR + TOF + PSF (77%); and an increase in the C TD from IR + PSF (72%) to IR + TOF (75%) and to IR + TOF + PSF (77%). Tests of the scanner/software combinations showed a decrease in FWHM from Gemini_TF (13 mm) to Biograph_mCT (12 mm) and to Discovery_690 (11 mm); an increase in the C IC from Gemini_TF (65%) to Biograph_mCT (73%) and to Discovery_690 (75%); and an increase in the C TD from Gemini_TF/Biograph_mCT (72%) to Discovery_690 (77%). CONCLUSION: The introduction of TOF and PSF increases image quality in cardiac 18F-FDG PET. The scanner/software combinations exhibit different performances, which should be taken into consideration when making cross comparisons.
BACKGROUND: The purpose of this study was to evaluate the image quality in cardiac 18F-FDG PET using the time of flight (TOF) and/or point spread function (PSF) modeling in the iterative reconstruction (IR). METHODS: Three scanners and an anthropomorphic cardiac phantom with an insert simulating a transmural defect (TD) were used. Two sets of scans (with/without TD) were acquired, and four reconstruction schemes were considered: (1) IR; (2) IR + PSF, (3) IR + TOF, and (4) IR + TOF + PSF. LV wall thickness (FWHM), contrast between LV wall and inner chamber (C IC), and TD contrast in LV wall (C TD) were evaluated. RESULTS: Tests of the reconstruction protocols showed a decrease in FWHM from IR (13 mm) to IR + PSF (11 mm); an increase in the C IC from IR (65%) to IR + PSF (71%) and from IR + TOF (72%) to IR + TOF + PSF (77%); and an increase in the C TD from IR + PSF (72%) to IR + TOF (75%) and to IR + TOF + PSF (77%). Tests of the scanner/software combinations showed a decrease in FWHM from Gemini_TF (13 mm) to Biograph_mCT (12 mm) and to Discovery_690 (11 mm); an increase in the C IC from Gemini_TF (65%) to Biograph_mCT (73%) and to Discovery_690 (75%); and an increase in the C TD from Gemini_TF/Biograph_mCT (72%) to Discovery_690 (77%). CONCLUSION: The introduction of TOF and PSF increases image quality in cardiac 18F-FDG PET. The scanner/software combinations exhibit different performances, which should be taken into consideration when making cross comparisons.
Entities:
Keywords:
PET; cardiac; point spread function; reconstruction algorithms; time of flight
Authors: Ludovic Le Meunier; Piotr J Slomka; Damini Dey; Amit Ramesh; Louis E J Thomson; Sean W Hayes; John D Friedman; Victor Cheng; Guido Germano; Daniel S Berman Journal: J Nucl Cardiol Date: 2010-02-12 Impact factor: 5.952
Authors: Ludovic Le Meunier; Piotr J Slomka; Damini Dey; Amit Ramesh; Louis E J Thomson; Sean W Hayes; John D Friedman; Victor Cheng; Guido Germano; Daniel S Berman Journal: J Nucl Cardiol Date: 2010-12-16 Impact factor: 5.952
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