Literature DB >> 25652479

Evaluation of Matrix9 silicon photomultiplier array for small-animal PET.

Junwei Du1, Jeffrey P Schmall1, Yongfeng Yang1, Kun Di1, Emilie Roncali1, Gregory S Mitchell1, Steve Buckley2, Carl Jackson2, Simon R Cherry3.   

Abstract

PURPOSE: The MatrixSL-9-30035-OEM (Matrix9) from SensL is a large-area silicon photomultiplier (SiPM) photodetector module consisting of a 3 × 3 array of 4 × 4 element SiPM arrays (total of 144 SiPM pixels) and incorporates SensL's front-end electronics board and coincidence board. Each SiPM pixel measures 3.16 × 3.16 mm(2) and the total size of the detector head is 47.8 × 46.3 mm(2). Using 8 × 8 polished LSO/LYSO arrays (pitch 1.5 mm) the performance of this detector system (SiPM array and readout electronics) was evaluated with a view for its eventual use in small-animal positron emission tomography (PET).
METHODS: Measurements of noise, signal, signal-to-noise ratio, energy resolution, flood histogram quality, timing resolution, and array trigger error were obtained at different bias voltages (28.0-32.5 V in 0.5 V intervals) and at different temperatures (5 °C-25 °C in 5 °C degree steps) to find the optimal operating conditions.
RESULTS: The best measured signal-to-noise ratio and flood histogram quality for 511 keV gamma photons were obtained at a bias voltage of 30.0 V and a temperature of 5 °C. The energy resolution and timing resolution under these conditions were 14.2% ± 0.1% and 4.2 ± 0.1 ns, respectively. The flood histograms show that all the crystals in the 1.5 mm pitch LSO array can be clearly identified and that smaller crystal pitches can also be resolved. Flood histogram quality was also calculated using different center of gravity based positioning algorithms. Improved and more robust results were achieved using the local 9 pixels for positioning along with an energy offset calibration. To evaluate the front-end detector readout, and multiplexing efficiency, an array trigger error metric is introduced and measured at different lower energy thresholds. Using a lower energy threshold greater than 150 keV effectively eliminates any mispositioning between SiPM arrays.
CONCLUSIONS: In summary, the Matrix9 detector system can resolve high-resolution scintillator arrays common in small-animal PET with adequate energy resolution and timing resolution over a large detector area. The modular design of the Matrix9 detector allows it to be used as a building block for simple, low channel-count, yet high performance, small animal PET or PET/MRI systems.

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Year:  2015        PMID: 25652479      PMCID: PMC4297283          DOI: 10.1118/1.4905088

Source DB:  PubMed          Journal:  Med Phys        ISSN: 0094-2405            Impact factor:   4.071


  17 in total

1.  Initial results of simultaneous PET/MRI experiments with an MRI-compatible silicon photomultiplier PET scanner.

Authors:  Hyun Suk Yoon; Guen Bae Ko; Sun Il Kwon; Chan Mi Lee; Mikiko Ito; In Chan Song; Dong Soo Lee; Seong Jong Hong; Jae Sung Lee
Journal:  J Nucl Med       Date:  2012-03-13       Impact factor: 10.057

Review 2.  The challenge of detector designs for PET.

Authors:  Thomas K Lewellen
Journal:  AJR Am J Roentgenol       Date:  2010-08       Impact factor: 3.959

3.  Performance comparison of Si-PM-based block detectors with different pixel sizes for an ultrahigh-resolution small-animal PET system.

Authors:  Seiichi Yamamoto; Hiroshi Watabe; Jun Hatazawa
Journal:  Phys Med Biol       Date:  2011-09-21       Impact factor: 3.609

4.  Development of a novel depth of interaction PET detector using highly multiplexed G-APD cross-strip encoding.

Authors:  A Kolb; C Parl; F Mantlik; C C Liu; E Lorenz; D Renker; B J Pichler
Journal:  Med Phys       Date:  2014-08       Impact factor: 4.071

5.  Performance of FBK high-density SiPM technology coupled to Ce:LYSO and Ce:GAGG for TOF-PET.

Authors:  Alessandro Ferri; Alberto Gola; Nicola Serra; Alessandro Tarolli; Nicola Zorzi; Claudio Piemonte
Journal:  Phys Med Biol       Date:  2014-02-03       Impact factor: 3.609

6.  A sub-millimeter resolution PET detector module using a multi-pixel photon counter array.

Authors:  Tae Yong Song; Heyu Wu; Sergey Komarov; Stefan B Siegel; Yuan-Chuan Tai
Journal:  Phys Med Biol       Date:  2010-04-14       Impact factor: 3.609

7.  Construction and Evaluation of a Prototype High Resolution, Silicon Photomultiplier-Based, Tandem Positron Emission Tomography System.

Authors:  Alexander V Stolin; Stan Majewski; Gangadhar Jaliparthi; Raymond R Raylman
Journal:  IEEE Trans Nucl Sci       Date:  2013-02       Impact factor: 1.679

8.  A Simple Capacitive Charge-Division Readout for Position-Sensitive Solid-State Photomultiplier Arrays.

Authors:  Junwei Du; Jeffrey P Schmall; Yongfeng Yang; Kun Di; Purushottam A Dokhale; Kanai S Shah; Simon R Cherry
Journal:  IEEE Trans Nucl Sci       Date:  2013-10       Impact factor: 1.679

9.  Signal and noise properties of position-sensitive avalanche photodiodes.

Authors:  Yongfeng Yang; Yibao Wu; Richard Farrell; Purushottam A Dokhale; Kanai S Shah; Simon R Cherry
Journal:  Phys Med Biol       Date:  2011-09-06       Impact factor: 3.609

10.  Investigation of analog charge multiplexing schemes for SiPM based PET block detectors.

Authors:  Evan Downie; Xin Yang; Hao Peng
Journal:  Phys Med Biol       Date:  2013-05-16       Impact factor: 3.609

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  6 in total

1.  A depth-of-interaction encoding PET detector module with dual-ended readout using large-area silicon photomultiplier arrays.

Authors:  Junwei Du; Xiaowei Bai; Simon R Cherry
Journal:  Phys Med Biol       Date:  2018-12-14       Impact factor: 3.609

2.  A Time-Walk Correction Method for PET Detectors Based on Leading Edge Discriminators.

Authors:  Junwei Du; Jeffrey P Schmall; Martin S Judenhofer; Kun Di; Yongfeng Yang; Simon R Cherry
Journal:  IEEE Trans Radiat Plasma Med Sci       Date:  2017-07-13

3.  Performance of a high-resolution depth-encoding PET detector module using linearly-graded SiPM arrays.

Authors:  Junwei Du; Xiaowei Bai; Alberto Gola; Fabio Acerbi; Alessandro Ferri; Claudio Piemonte; Yongfeng Yang; Simon R Cherry
Journal:  Phys Med Biol       Date:  2018-02-05       Impact factor: 3.609

4.  Performance Comparison of Different Readouts for Position-Sensitive Solid-State Photomultiplier Arrays.

Authors:  Junwei Du; Jeffrey P Schmall; Kun Di; Yongfeng Yang; Purushottam A Dokhale; Kanai S Shah; Simon R Cherry
Journal:  Biomed Phys Eng Express       Date:  2017-07-19

5.  A high resolution and high detection efficiency depth-encoding detector for brain positron emission tomography based on a 0.75 mm pitch scintillator array.

Authors:  J Du; S R Cherry
Journal:  J Instrum       Date:  2021-05-20       Impact factor: 1.415

6.  Characterization of Large-Area SiPM Array for PET Applications.

Authors:  Junwei Du; Yongfeng Yang; Xiaowei Bai; Martin S Judenhofer; Eric Berg; Kun Di; Steve Buckley; Carl Jackson; Simon R Cherry
Journal:  IEEE Trans Nucl Sci       Date:  2016-02-15       Impact factor: 1.679

  6 in total

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