Literature DB >> 2557315

Coexpression of platelet-derived growth factor (PDGF) A-chain and PDGF receptor genes in human gastric carcinomas.

T Tsuda1, K Yoshida, T Tsujino, H Nakayama, G Kajiyama, E Tahara.   

Abstract

In this study we examined the expression of platelet-derived growth factor (PDGF) A-chain and PDGF receptor genes in seven human gastric carcinoma cell lines and 15 gastric carcinoma tissues. Expression of mRNA for PDGF A-chain was found in all gastric cell lines and all gastric carcinoma tissues. Two of the seven gastric carcinoma cell lines expressed PDGF receptor mRNA. Out of the 15 gastric carcinoma tissues, eight showed enhanced expression of PDGF receptor mRNA and all of them demonstrated prominent fibrous stroma. Moreover, the incidence of enhanced expression of PDGF receptor mRNA was higher in scirrhous carcinoma than in well differentiated adenocarcinoma. These results strongly suggest that PDGF produced by tumor cells acts as a paracrine growth factor for production of fibrous stroma in gastric carcinomas.

Entities:  

Mesh：

Substances：

Year:  1989        PMID： 2557315      PMCID： PMC5917854          DOI： 10.1111/j.1349-7006.1989.tb01719.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  25 in total

1.  Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors.

Authors:  Y Yarden; J A Escobedo; W J Kuang; T L Yang-Feng; T O Daniel; P M Tremble; E Y Chen; M E Ando; R N Harkins; U Francke
Journal:  Nature       Date:  1986 Sep 18-24       Impact factor: 49.962

2.  Synthesis and secretion of platelet-derived growth factor by human breast cancer cell lines.

Authors:  D A Bronzert; P Pantazis; H N Antoniades; A Kasid; N Davidson; R B Dickson; M E Lippman
Journal:  Proc Natl Acad Sci U S A       Date:  1987-08       Impact factor: 11.205

3.  Tandem linkage of human CSF-1 receptor (c-fms) and PDGF receptor genes.

Authors:  W M Roberts; A T Look; M F Roussel; C J Sherr
Journal:  Cell       Date:  1988-11-18       Impact factor: 41.582

4.  Endothelial cell hyperplasia in human glioblastoma: coexpression of mRNA for platelet-derived growth factor (PDGF) B chain and PDGF receptor suggests autocrine growth stimulation.

Authors:  M Hermansson; M Nistér; C Betsholtz; C H Heldin; B Westermark; K Funa
Journal:  Proc Natl Acad Sci U S A       Date:  1988-10       Impact factor: 11.205

5.  Chromosomal mapping of the simian sarcoma virus onc gene analogue in human cells.

Authors:  D C Swan; O W McBride; K C Robbins; D A Keithley; E P Reddy; S A Aaronson
Journal:  Proc Natl Acad Sci U S A       Date:  1982-08       Impact factor: 11.205

6.  Human platelet-derived growth factor (PDGF): amino-terminal amino acid sequence.

Authors:  H N Antoniades; M W Hunkapiller
Journal:  Science       Date:  1983-05-27       Impact factor: 47.728

7.  A glioma-derived PDGF A chain homodimer has different functional activities from a PDGF AB heterodimer purified from human platelets.

Authors:  M Nistér; A Hammacher; K Mellström; A Siegbahn; L Rönnstrand; B Westermark; C H Heldin
Journal:  Cell       Date:  1988-03-25       Impact factor: 41.582

8.  Differential expression of platelet-derived growth factor and transforming growth factor genes in small- and non-small-cell human lung carcinoma lines.

Authors:  G Söderdahl; C Betsholtz; A Johansson; K Nilsson; J Bergh
Journal:  Int J Cancer       Date:  1988-04-15       Impact factor: 7.396

9.  A human osteosarcoma cell line secretes a growth factor structurally related to a homodimer of PDGF A-chains.

Authors:  C H Heldin; A Johnsson; S Wennergren; C Wernstedt; C Betsholtz; B Westermark
Journal:  Nature       Date:  1986 Feb 6-12       Impact factor: 49.962

10.  Epidermal growth factor induces the expression of its receptor gene in human gastric carcinoma cell line TMK-1.

Authors:  K Yoshida; A Takanashi; E Kyo; M Ito; H Ito; M Niimoto; T Hattori; E Tahara
Journal:  Jpn J Cancer Res       Date:  1989-08
View more
  9 in total

1.  Proprotein-processing endoprotease furin controls the growth and differentiation of gastric surface mucous cells.

Authors:  Y Konda; H Yokota; T Kayo; T Horiuchi; N Sugiyama; S Tanaka; K Takata; T Takeuchi
Journal:  J Clin Invest       Date:  1997-04-15       Impact factor: 14.808

Review 2.  Growth factors and oncogenes in human gastrointestinal carcinomas.

Authors:  E Tahara
Journal:  J Cancer Res Clin Oncol       Date:  1990       Impact factor: 4.553

3.  Clinical significance of platelet-derived growth factor receptor-β gene expression in stage II/III gastric cancer with S-1 adjuvant chemotherapy.

Authors:  Akio Higuchi; Takashi Oshima; Kazue Yoshihara; Kentaro Sakamaki; Toru Aoyama; Nobuyasu Suganuma; Naoto Yamamoto; Tsutomu Sato; Haruhiko Cho; Manabu Shiozawa; Takaki Yoshikawa; Yasushi Rino; Chikara Kunisaki; Toshio Imada; Munetaka Masuda
Journal:  Oncol Lett       Date:  2016-12-14       Impact factor: 2.967

4.  Expression of growth factors and their receptors in human esophageal carcinomas: regulation of expression by epidermal growth factor and transforming growth factor alpha.

Authors:  K Yoshida; H Kuniyasu; W Yasui; Y Kitadai; T Toge; E Tahara
Journal:  J Cancer Res Clin Oncol       Date:  1993       Impact factor: 4.553

5.  Coexpression of receptor-tyrosine-kinases in gastric adenocarcinoma--a rationale for a molecular targeting strategy?

Authors:  Daniel Drescher; Markus Moehler; Ines Gockel; Kirsten Frerichs; Annett Müller; Friedrich Dünschede; Thomas Borschitz; Stefan Biesterfeld; Martin Holtmann; Thomas Wehler; Andreas Teufel; Kerstin Herzer; Thomas Fischer; Martin R Berger; Theodor Junginger; Peter R Galle; Carl C Schimanski
Journal:  World J Gastroenterol       Date:  2007-07-14       Impact factor: 5.742

6.  Molecular mechanism of stomach carcinogenesis.

Authors:  E Tahara
Journal:  J Cancer Res Clin Oncol       Date:  1993       Impact factor: 4.553

7.  Expression of epidermal growth factor, transforming growth factor-alpha and their receptor genes in human gastric carcinomas; implication for autocrine growth.

Authors:  K Yoshida; E Kyo; T Tsujino; T Sano; M Niimoto; E Tahara
Journal:  Jpn J Cancer Res       Date:  1990-01

8.  Induction of growth factor-receptor and metalloproteinase genes by epidermal growth factor and/or transforming growth factor-alpha in human gastric carcinoma cell line MKN-28.

Authors:  K Yoshida; T Tsujino; W Yasui; T Kameda; T Sano; H Nakayama; T Toge; E Tahara
Journal:  Jpn J Cancer Res       Date:  1990-08

9.  Stroma-directed molecular targeted therapy in gastric cancer.

Authors:  Yasuhiko Kitadai; Michiyo Kodama; Kei Shinagawa
Journal:  Cancers (Basel)       Date:  2011-12-08       Impact factor: 6.639
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.