Literature DB >> 2846185

Tandem linkage of human CSF-1 receptor (c-fms) and PDGF receptor genes.

W M Roberts1, A T Look, M F Roussel, C J Sherr.   

Abstract

A 5' untranslated exon of the human CSF-1 receptor gene (c-fms) is separated by a 26 kb intron from the 32 kb receptor coding sequences. Nucleotide sequence analysis of cloned genomic DNA revealed that the 3' end of the PDGF receptor gene is located less than 0.5 kb upstream from this exon. Similarities in chromosomal localization, organization, and encoded amino acid sequences suggest that the genes encoding the CSF-1 and PDGF receptors arose through duplication. The as yet unidentified c-fms promoter/enhancer sequences may be confined to the nucleotides separating the two genes or could potentially lie within the PDGF receptor gene itself.

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Year:  1988        PMID： 2846185     DOI： 10.1016/0092-8674(88)90224-3

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  39 in total

Review 1.  Mouse chromosome 18.

Authors:  M T Davisson; K R Johnson
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

2.  Differential transcription of exon 1 of the human c-fms gene in placental trophoblasts and monocytes.

Authors:  J Visvader; I M Verma
Journal:  Mol Cell Biol       Date:  1989-03       Impact factor: 4.272

3.  The interleukin-7 receptor gene is at 5p13.

Authors:  M Lynch; E Baker; L S Park; G R Sutherland; R G Goodwin
Journal:  Hum Genet       Date:  1992-07       Impact factor: 4.132

4.  The human PDGF receptor alpha-subunit gene maps to chromosome 4 in close proximity to c-kit.

Authors:  R G Gronwald; D A Adler; J D Kelly; C M Disteche; D F Bowen-Pope
Journal:  Hum Genet       Date:  1990-08       Impact factor: 4.132

5.  Mouse platelet-derived growth factor receptor alpha gene is deleted in W19H and patch mutations on chromosome 5.

Authors:  E A Smith; M F Seldin; L Martinez; M L Watson; G G Choudhury; P A Lalley; J Pierce; S Aaronson; J Barker; S L Naylor
Journal:  Proc Natl Acad Sci U S A       Date:  1991-06-01       Impact factor: 11.205

6.  Coexpression of the genes for platelet-derived growth factor B-chain receptor and macrophage colony-stimulating factor 1 receptor during monocytic differentiation.

Authors:  P Pantazis; S Kharbanda; A S Goustin; T Galanopoulos; D Kufe
Journal:  Proc Natl Acad Sci U S A       Date:  1991-03-15       Impact factor: 11.205

7.  Genomic organization of the extracellular coding region of the human FGFR4 and FLT4 genes: evolution of the genes encoding receptor tyrosine kinases with immunoglobulin-like domains.

Authors:  F Agnès; M M Toux; C André; F Galibert
Journal:  J Mol Evol       Date:  1997-07       Impact factor: 2.395

8.  Two members of the JAK family of protein tyrosine kinases map to chromosomes 1p31.3 and 9p24.

Authors:  M A Pritchard; E Baker; D F Callen; G R Sutherland; A F Wilks
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

9.  Mouse NIH 3T3 cells expressing human colony-stimulating factor 1 (CSF-1) receptors overgrow in serum-free medium containing human CSF-1 as their only growth factor.

Authors:  M F Roussel; C J Sherr
Journal:  Proc Natl Acad Sci U S A       Date:  1989-10       Impact factor: 11.205

10.  Platelet-derived growth factor receptor alpha-subunit gene (Pdgfra) is deleted in the mouse patch (Ph) mutation.

Authors:  D A Stephenson; M Mercola; E Anderson; C Y Wang; C D Stiles; D F Bowen-Pope; V M Chapman
Journal:  Proc Natl Acad Sci U S A       Date:  1991-01-01       Impact factor: 11.205
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