Literature DB >> 2168868

Induction of growth factor-receptor and metalloproteinase genes by epidermal growth factor and/or transforming growth factor-alpha in human gastric carcinoma cell line MKN-28.

K Yoshida1, T Tsujino, W Yasui, T Kameda, T Sano, H Nakayama, T Toge, E Tahara.   

Abstract

We examined the effects of epidermal growth factor (EGF) and transforming growth factor-alpha (TGF-alpha) on EGF receptor (EGFR) phosphorylation and the expression of mRNAs for oncogenes, growth factors, their receptors and metalloproteinase genes by MKN-28 gastric carcinoma cells which express EGF, TGF-alpha and EGFR genes. Both EGF and TGF-alpha stimulated EGFR phosphorylation, EGF and TGF-alpha induced FOS, MYC and ERBB-2 oncogene expression. Interestingly, EGF increased the expression of mRNAs for TGF-alpha and EGFR. On the other hand, TGF-alpha increased TGF-alpha mRNA but decreased the expression of mRNAs for EGFR and TGF-beta. Furthermore, mRNAs for interstitial collagenase, stromelysin and procollagen type I genes were also enhanced after treatment with EGF and TGF-alpha. These results indicate that EGF and TGF-alpha successively evoke cascade phenomena which favor tumor progression, invasion and extracellular matrix formation, acting as autocrine growth regulators for gastric carcinomas.

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Year:  1990        PMID： 2168868      PMCID： PMC5918092          DOI： 10.1111/j.1349-7006.1990.tb02647.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


epidermal growth factor transforming growth factor‐α epidermal growth factor receptor polyadenylated complementary DNA kilobase
  41 in total

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9.  Expression of epidermal growth factor, transforming growth factor-alpha and their receptor genes in human gastric carcinomas; implication for autocrine growth.

Authors:  K Yoshida; E Kyo; T Tsujino; T Sano; M Niimoto; E Tahara
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Authors:  K Yoshida; A Takanashi; E Kyo; M Ito; H Ito; M Niimoto; T Hattori; E Tahara
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