Literature DB >> 2511181

Epidermal growth factor induces the expression of its receptor gene in human gastric carcinoma cell line TMK-1.

K Yoshida1, A Takanashi, E Kyo, M Ito, H Ito, M Niimoto, T Hattori, E Tahara.   

Abstract

To ascertain the possible autocrine pathway in the growth promotion of gastric carcinomas, a study was made on the effects of exogenous human epidermal growth factor (hEGF) on the expression of mRNA for EGF, transforming growth factor-a (TGF-a), EGF receptor, FOS and MYC genes by TMK-1 cells. Exogenous hEGF increased FOS and MYC mRNA levels 30 min and 1 h after the treatment, respectively. TMK-1 cells accumulated the mRNA for EGF receptor about 7- to 8-fold by 3 h after treatment. Expressions of mRNA for EGF and TGF-a genes were detected, but the amounts of the mRNA of these genes in TMK-1 cells were not altered after the treatment.

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Year:  1989        PMID： 2511181      PMCID： PMC5917832          DOI： 10.1111/j.1349-7006.1989.tb01708.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  16 in total

1.  Interaction between epidermal growth factor and its receptor in progression of human gastric carcinoma.

Authors:  W Yasui; J Hata; H Yokozaki; H Nakatani; A Ochiai; H Ito; E Tahara
Journal:  Int J Cancer       Date:  1988-02-15       Impact factor: 7.396

2.  Epidermal growth factor (EGF) stimulates EGF receptor synthesis.

Authors:  H S Earp; K S Austin; J Blaisdell; R A Rubin; K G Nelson; L W Lee; J W Grisham
Journal:  J Biol Chem       Date:  1986-04-15       Impact factor: 5.157

3.  Construction of a novel oncogene based on synthetic sequences encoding epidermal growth factor.

Authors:  D F Stern; D L Hare; M A Cecchini; R A Weinberg
Journal:  Science       Date:  1987-01-16       Impact factor: 47.728

4.  Interaction between transforming growth factor-alpha and c-Ha-ras p21 in progression of human gastric carcinoma.

Authors:  T Yamamoto; T Hattori; E Tahara
Journal:  Pathol Res Pract       Date:  1988-11       Impact factor: 3.250

5.  Epidermal-growth-factor-dependent transformation by a human EGF receptor proto-oncogene.

Authors:  T J Velu; L Beguinot; W C Vass; M C Willingham; G T Merlino; I Pastan; D R Lowy
Journal:  Science       Date:  1987-12-04       Impact factor: 47.728

6.  Modulation of epidermal growth factor receptor gene expression by transforming growth factor-beta in a human breast carcinoma cell line.

Authors:  J A Fernandez-Pol; D J Klos; P D Hamilton; V D Talkad
Journal:  Cancer Res       Date:  1987-08-15       Impact factor: 12.701

7.  Suppression of the EGF-dependent induction of c-myc proto-oncogene expression by transforming growth factor beta in a human breast carcinoma cell line.

Authors:  J A Fernandez-Pol; V D Talkad; D J Klos; P D Hamilton
Journal:  Biochem Biophys Res Commun       Date:  1987-05-14       Impact factor: 3.575

8.  Human epidermal growth factor precursor: cDNA sequence, expression in vitro and gene organization.

Authors:  G I Bell; N M Fong; M M Stempien; M A Wormsted; D Caput; L L Ku; M S Urdea; L B Rall; R Sanchez-Pescador
Journal:  Nucleic Acids Res       Date:  1986-11-11       Impact factor: 16.971

9.  Effect of human epidermal growth factor on cell growth and its receptor in human gastric carcinoma cell lines.

Authors:  A Ochiai; A Takanashi; N Takekura; K Yoshida; S Miyamori; T Harada; E Tahara
Journal:  Jpn J Clin Oncol       Date:  1988-03       Impact factor: 3.019

10.  Stimulation and inhibition of growth by EGF in different A431 cell clones is accompanied by the rapid induction of c-fos and c-myc proto-oncogenes.

Authors:  R Bravo; J Burckhardt; T Curran; R Müller
Journal:  EMBO J       Date:  1985-05       Impact factor: 11.598
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  7 in total

Review 1.  Growth factors and oncogenes in human gastrointestinal carcinomas.

Authors:  E Tahara
Journal:  J Cancer Res Clin Oncol       Date:  1990       Impact factor: 4.553

2.  Augmentation of 5-fluorouracil cytotoxicity by epidermal growth factor in a newly established human signet-ring cell carcinoma of the stomach in culture.

Authors:  K Aizawa; I Muto; S Suzuki; N Tanaka; H Yabusaki; S Tanaka; N Katayanagi; T Suzuki; O Tanaka; T Muto
Journal:  Surg Today       Date:  1994       Impact factor: 2.549

3.  Expression of epidermal growth factor, transforming growth factor-alpha and their receptor genes in human gastric carcinomas; implication for autocrine growth.

Authors:  K Yoshida; E Kyo; T Tsujino; T Sano; M Niimoto; E Tahara
Journal:  Jpn J Cancer Res       Date:  1990-01

4.  Induction of growth factor-receptor and metalloproteinase genes by epidermal growth factor and/or transforming growth factor-alpha in human gastric carcinoma cell line MKN-28.

Authors:  K Yoshida; T Tsujino; W Yasui; T Kameda; T Sano; H Nakayama; T Toge; E Tahara
Journal:  Jpn J Cancer Res       Date:  1990-08

5.  Overexpression of cyclin-dependent kinase-activating CDC25B phosphatase in human gastric carcinomas.

Authors:  Y Kudo; W Yasui; T Ue; S Yamamoto; H Yokozaki; H Nikai; E Tahara
Journal:  Jpn J Cancer Res       Date:  1997-10

6.  Expression of amphiregulin, a novel gene of the epidermal growth factor family, in human gastric carcinomas.

Authors:  Y Kitadai; W Yasui; H Yokozaki; H Kuniyasu; A Ayhan; K Haruma; G Kajiyama; G R Johnson; E Tahara
Journal:  Jpn J Cancer Res       Date:  1993-08

7.  Coexpression of platelet-derived growth factor (PDGF) A-chain and PDGF receptor genes in human gastric carcinomas.

Authors:  T Tsuda; K Yoshida; T Tsujino; H Nakayama; G Kajiyama; E Tahara
Journal:  Jpn J Cancer Res       Date:  1989-09
  7 in total

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