| Literature DB >> 28356977 |
Akio Higuchi1, Takashi Oshima1, Kazue Yoshihara1, Kentaro Sakamaki2, Toru Aoyama1, Nobuyasu Suganuma1, Naoto Yamamoto1, Tsutomu Sato1, Haruhiko Cho1, Manabu Shiozawa1, Takaki Yoshikawa1, Yasushi Rino1, Chikara Kunisaki3, Toshio Imada4, Munetaka Masuda1.
Abstract
Overall survival remains unsatisfactory in stage II/III gastric cancer, even after curative surgery and adjuvant chemotherapy. Platelet-derived growth factor receptor-β (PDGFR-β) is associated with the proliferation of cancer cells. The present study therefore investigated the association of PDGFR-β gene expression with patient outcome in 134 stage II/III gastric cancer patients who received adjuvant chemotherapy with S-1. Relative PDGFR-β gene expression was measured in surgical cancer tissue and adjacent normal mucosa specimens by reverse transcription-quantitative polymerase chain reaction. The PDGFR-β gene expression levels were found to be significantly higher in the cancer tissues compared with the adjacent normal mucosa. A high level of PDGFR-β gene expression was associated with a significantly poorer 5-year overall survival rate compared with a low level of PDGFR-β expression. Upon multivariate analysis, PDGFR-β gene expression was found to be an independent predictor of survival. Overall, the study indicates that PDGFR-β overexpression in gastric cancer tissues is a useful independent predictor of outcome in patients with stage II/III gastric cancer who receive adjuvant chemotherapy with S-1.Entities:
Keywords: PDGFR-β; adjuvant chemotherapy with S-1; prognostic factor; stage II/III gastric cancer; tyrosine kinase receptor
Year: 2016 PMID： 28356977 PMCID： PMC5351282 DOI： 10.3892/ol.2016.5494
Source DB: PubMed Journal: Oncol Lett ISSN： 1792-1074 Impact factor: 2.967