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Literature DB >> 24890513

Epigenetic control of immunity.

Meinrad Busslinger¹, Alexander Tarakhovsky².

Abstract

Immunity relies on the heterogeneity of immune cells and their ability to respond to pathogen challenges. In the adaptive immune system, lymphocytes display a highly diverse antigen receptor repertoire that matches the vast diversity of pathogens. In the innate immune system, the cell's heterogeneity and phenotypic plasticity enable flexible responses to changes in tissue homeostasis caused by infection or damage. The immune responses are calibrated by the graded activity of immune cells that can vary from yeast-like proliferation to lifetime dormancy. This article describes key epigenetic processes that contribute to the function of immune cells during health and disease.

Entities: Disease Species

Mesh：

Year: 2014 PMID： 24890513 PMCID： PMC4031963 DOI： 10.1101/cshperspect.a019307

Source DB: PubMed Journal: Cold Spring Harb Perspect Biol ISSN： 1943-0264 Impact factor: 10.005

140 in total

Review 1. RAGs and regulation of autoantibodies.

Authors: Mila Jankovic; Rafael Casellas; Nikos Yannoutsos; Hedda Wardemann; Michel C Nussenzweig
Journal: Annu Rev Immunol Date: 2004 Impact factor: 28.527

2. The B-cell identity factor Pax5 regulates distinct transcriptional programmes in early and late B lymphopoiesis.

Authors: Roger Revilla-I-Domingo; Ivan Bilic; Bojan Vilagos; Hiromi Tagoh; Anja Ebert; Ido M Tamir; Leonie Smeenk; Johanna Trupke; Andreas Sommer; Markus Jaritz; Meinrad Busslinger
Journal: EMBO J Date: 2012-06-05 Impact factor: 11.598

Review 3. The super elongation complex (SEC) family in transcriptional control.

Authors: Zhuojuan Luo; Chengqi Lin; Ali Shilatifard
Journal: Nat Rev Mol Cell Biol Date: 2012-08-16 Impact factor: 94.444

4. CCCTC-binding factor (CTCF) and cohesin influence the genomic architecture of the Igh locus and antisense transcription in pro-B cells.

Authors: Stephanie C Degner; Jiyoti Verma-Gaur; Timothy P Wong; Claudia Bossen; G Michael Iverson; Ali Torkamani; Christian Vettermann; Yin C Lin; Zhongliang Ju; Danae Schulz; Caroline S Murre; Barbara K Birshtein; Nicholas J Schork; Mark S Schlissel; Roy Riblet; Cornelis Murre; Ann J Feeney
Journal: Proc Natl Acad Sci U S A Date: 2011-05-23 Impact factor: 11.205

5. The transcriptional coactivators p300 and CBP are histone acetyltransferases.

Authors: V V Ogryzko; R L Schiltz; V Russanova; B H Howard; Y Nakatani
Journal: Cell Date: 1996-11-29 Impact factor: 41.582

6. A multifunctional element in the mouse Igκ locus that specifies repertoire and Ig loci subnuclear location.

Authors: Yougui Xiang; Xiaorong Zhou; Susannah L Hewitt; Jane A Skok; William T Garrard
Journal: J Immunol Date: 2011-03-25 Impact factor: 5.422

7. Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors.

Authors: César Cobaleda; Wolfram Jochum; Meinrad Busslinger
Journal: Nature Date: 2007-09-12 Impact factor: 49.962

8. In multiple myeloma, t(4;14)(p16;q32) is an adverse prognostic factor irrespective of FGFR3 expression.

Authors: Jonathan J Keats; Tony Reiman; Christopher A Maxwell; Brian J Taylor; Loree M Larratt; Michael J Mant; Andrew R Belch; Linda M Pilarski
Journal: Blood Date: 2002-10-03 Impact factor: 22.113

9. A role for cohesin in T-cell-receptor rearrangement and thymocyte differentiation.

Authors: Vlad C Seitan; Bingtao Hao; Kikuë Tachibana-Konwalski; Thais Lavagnolli; Hegias Mira-Bontenbal; Karen E Brown; Grace Teng; Tom Carroll; Anna Terry; Katie Horan; Hendrik Marks; David J Adams; David G Schatz; Luis Aragon; Amanda G Fisher; Michael S Krangel; Kim Nasmyth; Matthias Merkenschlager
Journal: Nature Date: 2011-08-10 Impact factor: 49.962

10. Frequency-modulated nuclear localization bursts coordinate gene regulation.

Authors: Long Cai; Chiraj K Dalal; Michael B Elowitz
Journal: Nature Date: 2008-09-25 Impact factor: 49.962

54 in total

Review 1. Long-Range Chromatin Interactions.

Authors: Job Dekker; Tom Misteli
Journal: Cold Spring Harb Perspect Biol Date: 2015-10-01 Impact factor: 10.005

Review 2. Harnessing the plasticity of CD4(+) T cells to treat immune-mediated disease.

Authors: Michel DuPage; Jeffrey A Bluestone
Journal: Nat Rev Immunol Date: 2016-02-15 Impact factor: 53.106

Review 3. Epigenetics of ciliates.

Authors: Douglas L Chalker; Eric Meyer; Kazufumi Mochizuki
Journal: Cold Spring Harb Perspect Biol Date: 2013-12-01 Impact factor: 10.005

Epigenetic control of immunity.

Review 1. RAGs and regulation of autoantibodies.

2. The B-cell identity factor Pax5 regulates distinct transcriptional programmes in early and late B lymphopoiesis.

Review 3. The super elongation complex (SEC) family in transcriptional control.

4. CCCTC-binding factor (CTCF) and cohesin influence the genomic architecture of the Igh locus and antisense transcription in pro-B cells.

5. The transcriptional coactivators p300 and CBP are histone acetyltransferases.

6. A multifunctional element in the mouse Igκ locus that specifies repertoire and Ig loci subnuclear location.

7. Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors.

8. In multiple myeloma, t(4;14)(p16;q32) is an adverse prognostic factor irrespective of FGFR3 expression.

9. A role for cohesin in T-cell-receptor rearrangement and thymocyte differentiation.

10. Frequency-modulated nuclear localization bursts coordinate gene regulation.

Review 1. Long-Range Chromatin Interactions.

Review 2. Harnessing the plasticity of CD4(+) T cells to treat immune-mediated disease.

Review 3. Epigenetics of ciliates.

Review 4. CpG island chromatin is shaped by recruitment of ZF-CxxC proteins.

Review 5. Epigenetic reprogramming of immune cells in injury, repair, and resolution.

Review 6. Writers and readers of histone acetylation: structure, mechanism, and inhibition.

Review 7. Erasers of histone acetylation: the histone deacetylase enzymes.

8. Pharmacological inhibition of bromodomain-containing proteins in inflammation.

Review 9. Epigenetic Mechanisms Dictating Eradication of Cancer by Natural Killer Cells.

Review 10. Histone and DNA Modifications as Regulators of Neuronal Development and Function.