| Literature DB >> 8945521 |
V V Ogryzko1, R L Schiltz, V Russanova, B H Howard, Y Nakatani.
Abstract
p300/CBP is a transcriptional adaptor that integrates signals from many sequence-specific activators via direct interactions. Various cellular and viral factors target p300/CBP to modulate transcription and/or cell cycle progression. One such factor, the cellular p300/CBP associated factor (PCAF), possesses intrinsic histone acetyltransferase activity. Here, we demonstrate that p300/CBP is not only a transcriptional adaptor but also a histone acetyltransferase. p300/CBP represents a novel class of acetyltransferases in that it does not have the conserved motif found among various other acetyltransferases. p300/CBP acetylates all four core histones in nucleosomes. These observations suggest that p300/CBP acetylates nucleosomes in concert with PCAF.Entities:
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Year: 1996 PMID： 8945521 DOI： 10.1016/s0092-8674(00)82001-2
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582