Literature DB >> 30064663

Epigenetic Mechanisms Dictating Eradication of Cancer by Natural Killer Cells.

Suresh Bugide1, Radoslav Janostiak1, Narendra Wajapeyee2.   

Abstract

Natural killer (NK) cells of the innate immune system are the first line of defense against infectious agents and cancer cells. However, only a few mechanisms that regulate eradication of tumors by NK cells have been identified. In this review, we present an account of epigenetic mechanisms that modulate the ability of NK cells to eradicate cancer cells. To date, several drugs that target epigenetic modifiers have shown clinical efficacy in cancer. Therefore, once a given epigenetic modifier is validated as a regulator of NK cell function, it can be targeted for NK cell-based cancer immunotherapies.
Copyright © 2018 Elsevier Inc. All rights reserved.

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Year:  2018        PMID： 30064663      PMCID： PMC6085095          DOI： 10.1016/j.trecan.2018.06.004

Source DB:  PubMed          Journal:  Trends Cancer        ISSN： 2405-8025


  120 in total

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