Literature DB >> 15032586

RAGs and regulation of autoantibodies.

Mila Jankovic1, Rafael Casellas, Nikos Yannoutsos, Hedda Wardemann, Michel C Nussenzweig.   

Abstract

Autoreactive antibodies are etiologic agents in a number of autoimmune diseases. Like all other antibodies these antibodies are produced in developing B cells by V(D)J recombination in the bone marrow. Three mechanisms regulate autoreactive B cells: deletion, receptor editing, and anergy. Here we review the prevalence of autoantibodies in the initial antibody repertoire, their regulation by receptor editing, and the role of the recombinase proteins (RAG1 and RAG2) in this process.

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Year:  2004        PMID： 15032586     DOI： 10.1146/annurev.immunol.22.012703.104707

Source DB:  PubMed          Journal:  Annu Rev Immunol        ISSN： 0732-0582            Impact factor:   28.527


  31 in total

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Review 2.  Overview of the immune response.

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4.  Self/Nonself-Immune Recognition and Signaling: A new journal tackles a problem at the center of immunological science.

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Journal:  Self Nonself       Date:  2010-01

Review 5.  The neonatal Fc receptor as therapeutic target in IgG-mediated autoimmune diseases.

Authors:  Alina Sesarman; Gestur Vidarsson; Cassian Sitaru
Journal:  Cell Mol Life Sci       Date:  2010-03-09       Impact factor: 9.261

6.  Heavy-chain receptor editing unbound.

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Journal:  Proc Natl Acad Sci U S A       Date:  2015-02-17       Impact factor: 11.205

7.  Potentially autoreactive naturally occurring transitional T3 B lymphocytes exhibit a unique signaling profile.

Authors:  Ganna A Liubchenko; Holly C Appleberry; V Michael Holers; Nirmal K Banda; Van C Willis; Taras Lyubchenko
Journal:  J Autoimmun       Date:  2012-02-24       Impact factor: 7.094

Review 8.  Role of recombination activating genes in the generation of antigen receptor diversity and beyond.

Authors:  Mayilaadumveettil Nishana; Sathees C Raghavan
Journal:  Immunology       Date:  2012-12       Impact factor: 7.397

Review 9.  Murine models of Omenn syndrome.

Authors:  Serre-Yu Wong; David B Roth
Journal:  J Clin Invest       Date:  2007-05       Impact factor: 14.808

10.  NF-kappaB activity marks cells engaged in receptor editing.

Authors:  Emily J Cadera; Fengyi Wan; Rupesh H Amin; Hector Nolla; Michael J Lenardo; Mark S Schlissel
Journal:  J Exp Med       Date:  2009-07-06       Impact factor: 14.307
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