Literature DB >> 24761022

Analysis of compounded pharmaceutical products to teach the importance of quality in an applied pharmaceutics laboratory course.

Alyssa Pignato1, Christine R Birnie1.   

Abstract

OBJECTIVE: To assess the effectiveness of a product-analysis laboratory exercise in teaching students the importance of quality in pharmaceutical compounding.
DESIGN: Second-year pharmacy students (N=77) participated in a pharmaceutical compounding laboratory exercise and subsequently analyzed their final product using ultraviolet (UV) spectrometry. ASSESSMENT: Reflection, survey instruments, and quiz questions were used to measure how well students understood the importance of quality in their compounded products. Product analysis showed that preparations compounded by students had an error range of 0.6% to 140%, with an average error of 23.7%. Students' reflections cited common sources of error, including inaccurate weighing, contamination, and product loss during both the compounding procedure and preparation of the sample for analysis. Ninety percent of students agreed that the exercise improved their understanding of the importance of quality in compounded pharmaceutical products. Most students (85.7%) reported that this exercise inspired them to be more diligent in their preparation of compounded products in their future careers.
CONCLUSION: Integrating an analytical assessment during a pharmaceutical compounding laboratory can enhance students' understanding of quality of compounded pharmaceutical products. It can also provide students a chance to reflect on sources of error to improve their compounding technique in the future.

Keywords:  analysis; compounding; pharmaceutics; pharmacy practice laboratory

Mesh:

Year:  2014        PMID: 24761022      PMCID: PMC3996393          DOI: 10.5688/ajpe78361

Source DB:  PubMed          Journal:  Am J Pharm Educ        ISSN: 0002-9459            Impact factor:   2.047


  8 in total

1.  Why analytical testing is needed in pharmaceutical compounding.

Authors:  Hassan Almoazen; Anthony C Samsa; Charles N May
Journal:  Am J Pharm Educ       Date:  2010-03-10       Impact factor: 2.047

2.  Retention of compounding skills among pharmacy students.

Authors:  John G Eley; Christine Birnie
Journal:  Am J Pharm Educ       Date:  2006-12-15       Impact factor: 2.047

3.  A laboratory exercise in capsule making.

Authors:  Krista D Capehart
Journal:  Am J Pharm Educ       Date:  2008-10-15       Impact factor: 2.047

4.  Stability of methimazole in poloxamer lecithin organogel to determine beyond-use date.

Authors:  Alyssa Pignato; Marvin Pankaskie; Christine Birnie
Journal:  Int J Pharm Compd       Date:  2010 Nov-Dec

5.  Accuracy in prescriptions compounded by pharmacy students.

Authors:  R P Shrewsbury; K H Deloatch
Journal:  Int J Pharm Compd       Date:  1998 Mar-Apr

6.  PostScription: Compounding Paradox: Taught Less and Practiced More.

Authors:  David W Newton
Journal:  Int J Pharm Compd       Date:  2003 Sep-Oct

7.  Regulating compounding pharmacies after NECC.

Authors:  Kevin Outterson
Journal:  N Engl J Med       Date:  2012-11-07       Impact factor: 91.245

8.  Assessment and recommendations of compounding education in AACP member institutions.

Authors:  Robert Shrewsbury; Sam Augustine; Christine Birnie; Karen Nagel; Dipan Ray; James Ruble; Kelly Scolaro; Jennifer Athay Adams
Journal:  Am J Pharm Educ       Date:  2012-09-10       Impact factor: 2.047

  8 in total
  6 in total

1.  The Positive Impact of an Extended Intervention on Dosing Accuracy of Student Compounded Suspensions.

Authors:  Emily C Darst; Robert P Shrewsbury
Journal:  Am J Pharm Educ       Date:  2019-06       Impact factor: 2.047

2.  Analytical Evaluation of the Accuracy and Retention of Compounding Skills Among PharmD Students.

Authors:  Mudit Mudit; Lloyd F Alfonso
Journal:  Am J Pharm Educ       Date:  2017-05       Impact factor: 2.047

3.  Student Self-Analysis of Their Nonsterile Preparations and its Effect on Compounding Confidence.

Authors:  Joyce S Jih; Robert P Shrewsbury
Journal:  Am J Pharm Educ       Date:  2018-12       Impact factor: 2.047

4.  A Student-Led Elective Provides Quality Improvement Feedback for a Required Compounding Course.

Authors:  Emily C Darst; Tanya K Makhlouf; Erin C Brannick; Taylor B Mitchell; Robert P Shrewsbury
Journal:  Am J Pharm Educ       Date:  2020-08       Impact factor: 2.047

5.  Acquisition and Retention of Sterile Compounding Accuracy Skills.

Authors:  Tracy M Kosinski; Michael C Brown; Katie Valdovinos; Pedro J Zavala
Journal:  Am J Pharm Educ       Date:  2017-08       Impact factor: 2.047

6.  Potency Analyses Provide Insight Into Student Aseptic Compounding Technique Errors.

Authors:  Rebecca K Lee; Robert P Shrewsbury
Journal:  Am J Pharm Educ       Date:  2019-11       Impact factor: 2.047

  6 in total

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