| Literature DB >> 24633409 |
Johan Hattne1, Nathaniel Echols1, Rosalie Tran1, Jan Kern1, Richard J Gildea2, Aaron S Brewster1, Roberto Alonso-Mori3, Carina Glöckner4, Julia Hellmich4, Hartawan Laksmono5, Raymond G Sierra5, Benedikt Lassalle-Kaiser1, Alyssa Lampe1, Guangye Han1, Sheraz Gul1, Dörte DiFiore4, Despina Milathianaki3, Alan R Fry3, Alan Miahnahri3, William E White3, Donald W Schafer3, M Marvin Seibert3, Jason E Koglin3, Dimosthenis Sokaras6, Tsu-Chien Weng6, Jonas Sellberg7, Matthew J Latimer6, Pieter Glatzel8, Petrus H Zwart1, Ralf W Grosse-Kunstleve1, Michael J Bogan9, Marc Messerschmidt3, Garth J Williams3, Sébastien Boutet3, Johannes Messinger10, Athina Zouni11, Junko Yano1, Uwe Bergmann3, Vittal K Yachandra1, Paul D Adams1, Nicholas K Sauter1.
Abstract
X-ray free-electron laser (XFEL) sources enable the use of crystallography to solve three-dimensional macromolecular structures under native conditions and without radiation damage. Results to date, however, have been limited by the challenge of deriving accurate Bragg intensities from a heterogeneous population of microcrystals, while at the same time modeling the X-ray spectrum and detector geometry. Here we present a computational approach designed to extract meaningful high-resolution signals from fewer diffraction measurements.Entities:
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Year: 2014 PMID： 24633409 PMCID： PMC4008696 DOI： 10.1038/nmeth.2887
Source DB: PubMed Journal: Nat Methods ISSN： 1548-7091 Impact factor: 28.547