John A Kennedy1, Ora Israel, Alex Frenkel. 1. Department of Nuclear Medicine, Rambam Health Care Campus, P.O. Box 9602, 31096, Haifa, Israel, j_kennedy@rambam.health.gov.il.
Abstract
BACKGROUND: A solid-state cadmium zinc telluride (CZT) SPECT device provides ultrafast myocardial perfusion imaging (MPI) with a spherical field-of-view (FOV). This study aims at determining the spatial resolution and sensitivity throughout this FOV as a guide for patient positioning. METHODS AND RESULTS: For this CZT camera (Discovery 570c, GE Healthcare), the iteratively reconstructed spatial resolution along 3 Cartesian axes was compared (average resolution 6.9 ± 1.0 mm full-width at half-maximum) using a 2 dimensional array of point sources in air which was aligned with a transverse plane shifted throughout the FOV. Sensitivity was plotted in the central transverse slice and axially in locations comparable to the placement of the heart in 266 rest/stress cardiac studies (M 78, age 63 ± 13 years). The average sensitivity was 0.46 ± 0.19 kc/s/MBq with a transverse gradient of 0.039 ± 0.001 kc/s/MBq/cm (8.9% of the sensitivity per cm). Reconstructed relative activity was uniform (uniformity <9%) and count rate was linear (R = 0.999) over 3 orders of magnitude. CONCLUSIONS: The CZT SPECT camera offers good resolution, sensitivity, and uniformity, and provides linearity in count rate. A gradient of >8%/cm in sensitivity justifies the crucial role of patient positioning with the heart closest to the detector.
BACKGROUND: A solid-state cadmium zinc telluride (CZT) SPECT device provides ultrafast myocardial perfusion imaging (MPI) with a spherical field-of-view (FOV). This study aims at determining the spatial resolution and sensitivity throughout this FOV as a guide for patient positioning. METHODS AND RESULTS: For this CZT camera (Discovery 570c, GE Healthcare), the iteratively reconstructed spatial resolution along 3 Cartesian axes was compared (average resolution 6.9 ± 1.0 mm full-width at half-maximum) using a 2 dimensional array of point sources in air which was aligned with a transverse plane shifted throughout the FOV. Sensitivity was plotted in the central transverse slice and axially in locations comparable to the placement of the heart in 266 rest/stress cardiac studies (M 78, age 63 ± 13 years). The average sensitivity was 0.46 ± 0.19 kc/s/MBq with a transverse gradient of 0.039 ± 0.001 kc/s/MBq/cm (8.9% of the sensitivity per cm). Reconstructed relative activity was uniform (uniformity <9%) and count rate was linear (R = 0.999) over 3 orders of magnitude. CONCLUSIONS: The CZT SPECT camera offers good resolution, sensitivity, and uniformity, and provides linearity in count rate. A gradient of >8%/cm in sensitivity justifies the crucial role of patient positioning with the heart closest to the detector.
Authors: Robert C Hendel; Brian G Abbott; Timothy M Bateman; Ron Blankstein; Dennis A Calnon; Jeffrey A Leppo; Jamshid Maddahi; Matthew M Schumaecker; Leslee J Shaw; R Parker Ward; David G Wolinsky Journal: J Nucl Cardiol Date: 2011-02 Impact factor: 5.952
Authors: Robert C Hendel; Daniel S Berman; Marcelo F Di Carli; Paul A Heidenreich; Robert E Henkin; Patricia A Pellikka; Gerald M Pohost; Kim A Williams Journal: J Am Coll Cardiol Date: 2009-06-09 Impact factor: 24.094
Authors: Sanjiv S Gambhir; Daniel S Berman; Jack Ziffer; Michael Nagler; Martin Sandler; Jim Patton; Brian Hutton; Tali Sharir; Shlomo Ben Haim; Simona Ben Haim Journal: J Nucl Med Date: 2009-04 Impact factor: 10.057
Authors: Simona Ben-Haim; Venkatesh L Murthy; Christopher Breault; Rayjanah Allie; Arkadiusz Sitek; Nathaniel Roth; Jolene Fantony; Stephen C Moore; Mi-Ae Park; Marie Kijewski; Athar Haroon; Piotr Slomka; Kjell Erlandsson; Rafael Baavour; Yoel Zilberstien; Jamshed Bomanji; Marcelo F Di Carli Journal: J Nucl Med Date: 2013-04-11 Impact factor: 10.057
Authors: Fabio P Esteves; Paolo Raggi; Russell D Folks; Zohar Keidar; J Wells Askew; Shmuel Rispler; Michael K O'Connor; Liudmilla Verdes; Ernest V Garcia Journal: J Nucl Cardiol Date: 2009-08-18 Impact factor: 5.952
Authors: Hui Liu; Chung Chan; Yariv Grobshtein; Tianyu Ma; Yaqiang Liu; Shi Wang; Mitchel R Stacy; Albert J Sinusas; Chi Liu Journal: Phys Med Biol Date: 2015-08-21 Impact factor: 3.609
Authors: Sharmila Dorbala; Karthik Ananthasubramaniam; Ian S Armstrong; Panithaya Chareonthaitawee; E Gordon DePuey; Andrew J Einstein; Robert J Gropler; Thomas A Holly; John J Mahmarian; Mi-Ae Park; Donna M Polk; Raymond Russell; Piotr J Slomka; Randall C Thompson; R Glenn Wells Journal: J Nucl Cardiol Date: 2018-10 Impact factor: 5.952