| Literature DB >> 23851459 |
Melanie Weisser1, Felix Voigts-Hoffmann, Julius Rabl, Marc Leibundgut, Nenad Ban.
Abstract
Eukaryotic translation initiation factors (eIFs) 1A and 1 are central players in the complex process of start-codon recognition. To improve mechanistic understanding of this process, we determined the crystal structure of the 40S ribosomal subunit in complex with eIF1A and eIF1 from Tetrahymena thermophila at a resolution of 3.7 Å. It reveals the positions of the two factors on the 40S and the conformational changes that accompany their binding.Entities:
Mesh:
Substances:
Year: 2013 PMID: 23851459 DOI: 10.1038/nsmb.2622
Source DB: PubMed Journal: Nat Struct Mol Biol ISSN: 1545-9985 Impact factor: 15.369