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Literature DB >> 24096398

Zooming in on eukaryotic translation initiation.

Abstract

Translation initiation in eukaryotes is a complex and highly regulated process during which several initiation factors cooperate to recruit an initiator tRNA to the small ribosomal subunit, where the mRNA is scanned for an AUG start codon. Two recent reports provide new structural insights into this process and reveal key functions of initiation factors 1 (eIF1) and 1A (eIF1A) in start-codon selection in atomic detail.

Entities: Gene

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Year: 2013 PMID： 24096398 DOI： 10.1038/nsmb.2684

Source DB: PubMed Journal: Nat Struct Mol Biol ISSN： 1545-9985 Impact factor: 15.369

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References

13 in total

1. Crystal structure of the ribosome at 5.5 A resolution.

Authors: M M Yusupov; G Z Yusupova; A Baucom; K Lieberman; T N Earnest; J H Cate; H F Noller
Journal: Science Date: 2001-03-29 Impact factor: 47.728

2. Recognition of cognate transfer RNA by the 30S ribosomal subunit.

Authors: J M Ogle; D E Brodersen; W M Clemons ; M J Tarry; A P Carter; V Ramakrishnan
Journal: Science Date: 2001-05-04 Impact factor: 47.728

3. Communication between eukaryotic translation initiation factors 1 and 1A on the yeast small ribosomal subunit.

Authors: David Maag; Jon R Lorsch
Journal: J Mol Biol Date: 2003-07-25 Impact factor: 5.469

Review 4. A mechanistic overview of translation initiation in eukaryotes.

Authors: Colin Echeverría Aitken; Jon R Lorsch
Journal: Nat Struct Mol Biol Date: 2012-06-05 Impact factor: 15.369

Review 5. How do eucaryotic ribosomes select initiation regions in messenger RNA?

Authors: M Kozak
Journal: Cell Date: 1978-12 Impact factor: 41.582

6. Regulatory elements in eIF1A control the fidelity of start codon selection by modulating tRNA(i)(Met) binding to the ribosome.

Authors: Adesh K Saini; Jagpreet S Nanda; Jon R Lorsch; Alan G Hinnebusch
Journal: Genes Dev Date: 2010-01-01 Impact factor: 11.361

Zooming in on eukaryotic translation initiation.

1. Crystal structure of the ribosome at 5.5 A resolution.

2. Recognition of cognate transfer RNA by the 30S ribosomal subunit.

3. Communication between eukaryotic translation initiation factors 1 and 1A on the yeast small ribosomal subunit.

Review 4. A mechanistic overview of translation initiation in eukaryotes.

Review 5. How do eucaryotic ribosomes select initiation regions in messenger RNA?

6. Regulatory elements in eIF1A control the fidelity of start codon selection by modulating tRNA(i)(Met) binding to the ribosome.

Review 7. Structural insights into eukaryotic ribosomes and the initiation of translation.

8. N- and C-terminal residues of eIF1A have opposing effects on the fidelity of start codon selection.

9. eIF1 controls multiple steps in start codon recognition during eukaryotic translation initiation.

10. The eukaryotic translation initiation factors eIF1 and eIF1A induce an open conformation of the 40S ribosome.