Literature DB >> 22107593

Ribosomal route to small-molecule diversity.

Ma Diarey B Tianero1, Mohamed S Donia, Travis S Young, Peter G Schultz, Eric W Schmidt.   

Abstract

The cyanobactin ribosomal peptide (RP) natural product pathway was manipulated to incorporate multiple tandem mutations and non-proteinogenic amino acids, using eight heterologous components simultaneously expressed in Escherichia coli . These studies reveal the potential of RPs for the rational synthesis of complex, new small molecules over multiple-step biosynthetic pathways using simple genetic engineering.
© 2011 American Chemical Society

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Year:  2011        PMID： 22107593      PMCID： PMC3268757          DOI： 10.1021/ja208278k

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  39 in total

1.  Linking chemistry and genetics in the growing cyanobactin natural products family.

Authors:  Mohamed S Donia; Eric W Schmidt
Journal:  Chem Biol       Date:  2011-04-22

Review 2.  Natural products from synthetic biology.

Authors:  Wayne Mitchell
Journal:  Curr Opin Chem Biol       Date:  2011-08       Impact factor: 8.822

3.  Introducing lasso peptides as molecular scaffolds for drug design: engineering of an integrin antagonist.

Authors:  Thomas A Knappe; Florian Manzenrieder; Carlos Mas-Moruno; Uwe Linne; Florenz Sasse; Horst Kessler; Xiulan Xie; Mohamed A Marahiel
Journal:  Angew Chem Int Ed Engl       Date:  2011-08-02       Impact factor: 15.336

4.  Enzymatic basis of ribosomal peptide prenylation in cyanobacteria.

Authors:  John A McIntosh; Mohamed S Donia; Satish K Nair; Eric W Schmidt
Journal:  J Am Chem Soc       Date:  2011-08-04       Impact factor: 15.419

5.  Posttranslational heterocyclization of cysteine and serine residues in the antibiotic microcin B17: distributivity and directionality.

Authors:  N L Kelleher; C L Hendrickson; C T Walsh
Journal:  Biochemistry       Date:  1999-11-23       Impact factor: 3.162

6.  Total synthesis and revision of stereochemistry of the marine metabolite trunkamide A.

Authors:  P Wipf; Y Uto
Journal:  J Org Chem       Date:  2000-02-25       Impact factor: 4.354

7.  Evolution of cyclic peptide protease inhibitors.

Authors:  Travis S Young; Douglas D Young; Insha Ahmad; John M Louis; Stephen J Benkovic; Peter G Schultz
Journal:  Proc Natl Acad Sci U S A       Date:  2011-06-20       Impact factor: 11.205

8.  Accessing the hidden majority of marine natural products through metagenomics.

Authors:  Mohamed S Donia; Duane E Ruffner; Sheng Cao; Eric W Schmidt
Journal:  Chembiochem       Date:  2011-05-03       Impact factor: 3.164

9.  Cloning and engineering of the cinnamycin biosynthetic gene cluster from Streptomyces cinnamoneus cinnamoneus DSM 40005.

Authors:  D A Widdick; H M Dodd; P Barraille; J White; T H Stein; K F Chater; M J Gasson; M J Bibb
Journal:  Proc Natl Acad Sci U S A       Date:  2003-03-17       Impact factor: 11.205

10.  A marine natural product, patellamide D, reverses multidrug resistance in a human leukemic cell line.

Authors:  A B Williams; R S Jacobs
Journal:  Cancer Lett       Date:  1993-07-30       Impact factor: 8.679
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  58 in total

1.  Elucidating the Specificity Determinants of the AtxE2 Lasso Peptide Isopeptidase.

Authors:  Mikhail O Maksimov; Joseph D Koos; Chuhan Zong; Bozhena Lisko; A James Link
Journal:  J Biol Chem       Date:  2015-11-03       Impact factor: 5.157

2.  Metabolic model for diversity-generating biosynthesis.

Authors:  Ma Diarey Tianero; Elizabeth Pierce; Shrinivasan Raghuraman; Debosmita Sardar; John A McIntosh; John R Heemstra; Zachary Schonrock; Brett C Covington; J Alan Maschek; James E Cox; Brian O Bachmann; Baldomero M Olivera; Duane E Ruffner; Eric W Schmidt
Journal:  Proc Natl Acad Sci U S A       Date:  2016-02-01       Impact factor: 11.205

3.  The secret to a successful relationship: lasting chemistry between ascidians and their symbiotic bacteria.

Authors:  Eric W Schmidt
Journal:  Invertebr Biol       Date:  2015-03-01       Impact factor: 1.250

4.  Facile Removal of Leader Peptides from Lanthipeptides by Incorporation of a Hydroxy Acid.

Authors:  Noah A Bindman; Silvia C Bobeica; Wenshe R Liu; Wilfred A van der Donk
Journal:  J Am Chem Soc       Date:  2015-06-01       Impact factor: 15.419

Review 5.  Recent advances in natural product discovery.

Authors:  Yunzi Luo; Ryan E Cobb; Huimin Zhao
Journal:  Curr Opin Biotechnol       Date:  2014-09-26       Impact factor: 9.740

6.  Directing Biosynthesis: Practical Supply of Natural and Unnatural Cyanobactins.

Authors:  D Sardar; M D Tianero; E W Schmidt
Journal:  Methods Enzymol       Date:  2016-03-16       Impact factor: 1.600

7.  Recombinant thiopeptides containing noncanonical amino acids.

Authors:  Xiaozhou Luo; Claudio Zambaldo; Tao Liu; Yuhan Zhang; Weimin Xuan; Chen Wang; Sean A Reed; Peng-Yu Yang; Rongsheng E Wang; Tsotne Javahishvili; Peter G Schultz; Travis S Young
Journal:  Proc Natl Acad Sci U S A       Date:  2016-03-14       Impact factor: 11.205

8.  In Vitro Biosynthesis and Substrate Tolerance of the Plantazolicin Family of Natural Products.

Authors:  Caitlin D Deane; Brandon J Burkhart; Patricia M Blair; Jonathan I Tietz; Alice Lin; Douglas A Mitchell
Journal:  ACS Chem Biol       Date:  2016-06-16       Impact factor: 5.100

9.  Substrate Recognition by the Class II Lanthipeptide Synthetase HalM2.

Authors:  Imran R Rahman; Jeella Z Acedo; Xiaoran Roger Liu; Lingyang Zhu; Justine Arrington; Michael L Gross; Wilfred A van der Donk
Journal:  ACS Chem Biol       Date:  2020-04-28       Impact factor: 5.100

10.  Thiazoline peptides and a tris-phenethyl urea from Didemnum molle with anti-HIV activity.

Authors:  Zhenyu Lu; Mary Kay Harper; Christopher D Pond; Louis R Barrows; Chris M Ireland; Ryan M Van Wagoner
Journal:  J Nat Prod       Date:  2012-07-30       Impact factor: 4.050
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