Literature DB >> 21361208

Patient-specific radiation dose and cancer risk estimation in CT: part I. development and validation of a Monte Carlo program.

Xiang Li1, Ehsan Samei, W Paul Segars, Gregory M Sturgeon, James G Colsher, Greta Toncheva, Terry T Yoshizumi, Donald P Frush.   

Abstract

PURPOSE: Radiation-dose awareness and optimization in CT can greatly benefit from a dose-reporting system that provides dose and risk estimates specific to each patient and each CT examination. As the first step toward patient-specific dose and risk estimation, this article aimed to develop a method for accurately assessing radiation dose from CT examinations.
METHODS: A Monte Carlo program was developed to model a CT system (LightSpeed VCT, GE Healthcare). The geometry of the system, the energy spectra of the x-ray source, the three-dimensional geometry of the bowtie filters, and the trajectories of source motions during axial and helical scans were explicitly modeled. To validate the accuracy of the program, a cylindrical phantom was built to enable dose measurements at seven different radial distances from its central axis. Simulated radial dose distributions in the cylindrical phantom were validated against ion chamber measurements for single axial scans at all combinations of tube potential and bowtie filter settings. The accuracy of the program was further validated using two anthropomorphic phantoms (a pediatric one-year-old phantom and an adult female phantom). Computer models of the two phantoms were created based on their CT data and were voxelized for input into the Monte Carlo program. Simulated dose at various organ locations was compared against measurements made with thermoluminescent dosimetry chips for both single axial and helical scans.
RESULTS: For the cylindrical phantom, simulations differed from measurements by -4.8% to 2.2%. For the two anthropomorphic phantoms, the discrepancies between simulations and measurements ranged between (-8.1%, 8.1%) and (-17.2%, 13.0%) for the single axial scans and the helical scans, respectively.
CONCLUSIONS: The authors developed an accurate Monte Carlo program for assessing radiation dose from CT examinations. When combined with computer models of actual patients, the program can provide accurate dose estimates for specific patients.

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Year:  2011        PMID: 21361208      PMCID: PMC3021562          DOI: 10.1118/1.3515839

Source DB:  PubMed          Journal:  Med Phys        ISSN: 0094-2405            Impact factor:   4.071


  23 in total

1.  The feasibility of a scanner-independent technique to estimate organ dose from MDCT scans: using CTDIvol to account for differences between scanners.

Authors:  Adam C Turner; Maria Zankl; John J DeMarco; Chris H Cagnon; Di Zhang; Erin Angel; Dianna D Cody; Donna M Stevens; Cynthia H McCollough; Michael F McNitt-Gray
Journal:  Med Phys       Date:  2010-04       Impact factor: 4.071

2.  The 'Image Gently' campaign: increasing CT radiation dose awareness through a national education and awareness program.

Authors:  Marilyn J Goske; Kimberly E Applegate; Jennifer Boylan; Penny F Butler; Michael J Callahan; Brian D Coley; Shawn Farley; Donald P Frush; Marta Hernanz-Schulman; Diego Jaramillo; Neil D Johnson; Sue C Kaste; Gregory Morrison; Keith J Strauss; Nora Tuggle
Journal:  Pediatr Radiol       Date:  2008-01-17

3.  A Monte Carlo-based method to estimate radiation dose from spiral CT: from phantom testing to patient-specific models.

Authors:  G Jarry; J J DeMarco; U Beifuss; C H Cagnon; M F McNitt-Gray
Journal:  Phys Med Biol       Date:  2003-08-21       Impact factor: 3.609

4.  Patient-specific radiation dose and cancer risk estimation in CT: part II. Application to patients.

Authors:  Xiang Li; Ehsan Samei; W Paul Segars; Gregory M Sturgeon; James G Colsher; Greta Toncheva; Terry T Yoshizumi; Donald P Frush
Journal:  Med Phys       Date:  2011-01       Impact factor: 4.071

5.  Influence of patient age on normalized effective doses calculated for CT examinations.

Authors:  A Khursheed; M C Hillier; P C Shrimpton; B F Wall
Journal:  Br J Radiol       Date:  2002-10       Impact factor: 3.039

Review 6.  The GSF family of voxel phantoms.

Authors:  Nina Petoussi-Henss; Maria Zanki; Ute Fill; Dieter Regulla
Journal:  Phys Med Biol       Date:  2002-01-07       Impact factor: 3.609

7.  Reducing radiation dose to selected organs by selecting the tube start angle in MDCT helical scans: a Monte Carlo based study.

Authors:  Di Zhang; Maria Zankl; John J DeMarco; Chris H Cagnon; Erin Angel; Adam C Turner; Michael F McNitt-Gray
Journal:  Med Phys       Date:  2009-12       Impact factor: 4.071

8.  Managing patient dose in multi-detector computed tomography(MDCT). ICRP Publication 102.

Authors:  J Valentin
Journal:  Ann ICRP       Date:  2007

9.  Realistic CT simulation using the 4D XCAT phantom.

Authors:  W P Segars; M Mahesh; T J Beck; E C Frey; B M W Tsui
Journal:  Med Phys       Date:  2008-08       Impact factor: 4.071

10.  Hybrid computational phantoms of the 15-year male and female adolescent: applications to CT organ dosimetry for patients of variable morphometry.

Authors:  Choonsik Lee; Daniel Lodwick; Jonathan L Williams; Wesley E Bolch
Journal:  Med Phys       Date:  2008-06       Impact factor: 4.071

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  41 in total

1.  The development of a population of 4D pediatric XCAT phantoms for imaging research and optimization.

Authors:  W P Segars; Hannah Norris; Gregory M Sturgeon; Yakun Zhang; Jason Bond; Anum Minhas; Daniel J Tward; J T Ratnanather; M I Miller; D Frush; E Samei
Journal:  Med Phys       Date:  2015-08       Impact factor: 4.071

2.  Pediatric chest and abdominopelvic CT: organ dose estimation based on 42 patient models.

Authors:  Xiaoyu Tian; Xiang Li; W Paul Segars; Erik K Paulson; Donald P Frush; Ehsan Samei
Journal:  Radiology       Date:  2013-10-28       Impact factor: 11.105

3.  The impact on CT dose of the variability in tube current modulation technology: a theoretical investigation.

Authors:  Xiang Li; W Paul Segars; Ehsan Samei
Journal:  Phys Med Biol       Date:  2014-07-28       Impact factor: 3.609

4.  DukeSim: A Realistic, Rapid, and Scanner-Specific Simulation Framework in Computed Tomography.

Authors:  Ehsan Abadi; Brian Harrawood; Shobhit Sharma; Anuj Kapadia; William P Segars; Ehsan Samei
Journal:  IEEE Trans Med Imaging       Date:  2018-12-12       Impact factor: 10.048

Review 5.  CT dose and risk estimates in children.

Authors:  Donald P Frush
Journal:  Pediatr Radiol       Date:  2011-08-17

6.  Patient-based estimation of organ dose for a population of 58 adult patients across 13 protocol categories.

Authors:  Pooyan Sahbaee; W Paul Segars; Ehsan Samei
Journal:  Med Phys       Date:  2014-07       Impact factor: 4.071

7.  Organ dose variability and trends in tomosynthesis and radiography.

Authors:  Jocelyn Hoye; Yakun Zhang; Greeshma Agasthya; Greg Sturgeon; Anuj Kapadia; W Paul Segars; Ehsan Samei
Journal:  J Med Imaging (Bellingham)       Date:  2017-08-01

8.  Breast dose reduction with organ-based, wide-angle tube current modulated CT.

Authors:  Wanyi Fu; Gregory M Sturgeon; Greeshma Agasthya; William Paul Segars; Anuj J Kapadia; Ehsan Samei
Journal:  J Med Imaging (Bellingham)       Date:  2017-08-04

9.  Extending the concept of weighted CT dose index to elliptical phantoms of various aspect ratios.

Authors:  Andrey Markovich; Ashraf G Morgan; Frank F Dong; Andrew N Primak; Xiang Li
Journal:  J Med Imaging (Bellingham)       Date:  2017-07-05

10.  PATIENT-SPECIFIC DOSE ESTIMATES IN DYNAMIC COMPUTED TOMOGRAPHY MYOCARDIAL PERFUSION EXAMINATION.

Authors:  V-M Sundell; M Kortesniemi; T Siiskonen; A Kosunen; S Rosendahl; L Büermann
Journal:  Radiat Prot Dosimetry       Date:  2021-01-15       Impact factor: 0.972

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